Familial hypobetalipoproteinemia.

Autor: MF Linton, RV Farese, Jr, SG Young

Publikováno v: Journal of Lipid Research, Vol 34, Iss 4, Pp 521-541 (1993)

Externí odkaz: https://doaj.org/article/ba04582170b145e38284de2bc12a9975

A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia.

Autor: RV Farese, Jr, A Garg, VR Pierotti, GL Vega, SG Young

Publikováno v: Journal of Lipid Research, Vol 33, Iss 4, Pp 569-577 (1992)

Familial hypobetalipoproteinemia, a syndrome associated with low plasma cholesterol levels, can be caused by apoB gene mutations. We identified a healthy 42-year-old man whose total plasma cholesterol level was 80 mg/dl. His plasma very low density l

Externí odkaz: https://doaj.org/article/a0a734e1797b417cbf374165cbeddb36

Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity.

Autor: Chitraju C; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Cell Biology, Harvard Medical School, Boston, United States., Fischer AW; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Cell Biology, Harvard Medical School, Boston, United States., Ambaw YA; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Cell Biology, Harvard Medical School, Boston, United States.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States., Wang K; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Cell Biology, Harvard Medical School, Boston, United States., Yuan B; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States., Hui S; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States., Walther TC; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Cell Biology, Harvard Medical School, Boston, United States.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.; Broad Institute of Harvard and MIT, Cambridge, United States.; Howard Hughes Medical Institute, Boston, United States., Farese RV Jr; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States.; Department of Cell Biology, Harvard Medical School, Boston, United States.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.; Broad Institute of Harvard and MIT, Cambridge, United States.

Publikováno v: ELife [Elife] 2023 Oct 02; Vol. 12. Date of Electronic Publication: 2023 Oct 02.

The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification.

Autor: Wang K; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Lee CW; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Sui X; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.; Department of Biochemistry and Biophysics, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX, USA., Kim S; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Wang S; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Higgs AB; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Baublis AJ; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.; Harvard T.H. Chan Advanced Multi-Omics Platform, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Voth GA; Department of Chemistry, Chicago Center for Theoretical Chemistry, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA., Liao M; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. liaomf@sustech.edu.cn.; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. liaomf@sustech.edu.cn., Walther TC; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA. twalther@mskcc.org.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. twalther@mskcc.org.; Harvard T.H. Chan Advanced Multi-Omics Platform, Harvard T.H. Chan School of Public Health, Boston, MA, USA. twalther@mskcc.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. twalther@mskcc.org.; Howard Hughes Medical Institute, Boston, MA, USA. twalther@mskcc.org.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. twalther@mskcc.org., Farese RV Jr; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA. rfarese@mskcc.org.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. rfarese@mskcc.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rfarese@mskcc.org.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rfarese@mskcc.org.

Publikováno v: Nature communications [Nat Commun] 2023 Jun 14; Vol. 14 (1), pp. 3533. Date of Electronic Publication: 2023 Jun 14.

Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.

Autor: Sui X; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.; Department of Biochemistry and Biophysics, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX, USA., Wang K; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Song K; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Cryo-EM Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA., Xu C; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Cryo-EM Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA., Song J; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Lee CW; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Liao M; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. liaomf@sustech.edu.cn.; School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. liaomf@sustech.edu.cn., Farese RV Jr; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA. robert@mskcc.org.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. robert@mskcc.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. robert@mskcc.org.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. robert@mskcc.org., Walther TC; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA. twalther@mskcc.org.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. twalther@mskcc.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. twalther@mskcc.org.; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. twalther@mskcc.org.; Howard Hughes Medical Institute, Boston, MA, USA. twalther@mskcc.org.

Publikováno v: Nature communications [Nat Commun] 2023 May 29; Vol. 14 (1), pp. 3100. Date of Electronic Publication: 2023 May 29.