Zobrazeno 1 - 10
of 89
pro vyhledávání: '"RUTH F. NUTT"'
Publikováno v:
International Journal of Peptide and Protein Research. 42:194-203
The endothelin family of polypeptides are known to exert potent physiological effects which include cardiovascular regulation. The solution conformation and dynamics of c(D-Trp-D-Cys(SO3-Na+)-Pro-D-Val-Leu), a potent endothelin-A receptor-selective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ea807b3f377f45e2b23bca77ac07a4
https://doi.org/10.1111/j.1399-3011.1993.tb00496.x
https://doi.org/10.1111/j.1399-3011.1993.tb00496.x
Autor:
Paul S. Anderson, Steven M. Pitzenberger, Ruth F. Nutt, Stephen F. Brady, C. D. Colton, J. T. Sisko, M.J. Bogusky, A.M. Naylor, Daniel F. Veber
Publikováno v:
International Journal of Peptide and Protein Research. 39:63-76
The tripeptide sequence arginine-glycine-aspartic acid (RGD) has been shown to be the key recognition segment in numerous cell adhesion proteins. The solution conformation and dynamics in DMSO-d6 of the cyclic pentapeptides, Ac-Cys-Arg-Gly-Asp-Cys-OH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e78aa63e1c2adb5440c22d4041ab44
https://doi.org/10.1111/j.1399-3011.1992.tb01557.x
https://doi.org/10.1111/j.1399-3011.1992.tb01557.x
Publikováno v:
Tetrahedron Letters. 42:6271-6274
The Passerini reaction between suitably protected alaninal, leucine isonitrile, and ornithine components delivered adducts 10a , b in high yield. Orthogonal N -deprotection of 10a led, via a smooth O - to N -acyl migration, to 11 , which constitutes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ed86f72cec35efedf64418babe6d7a
https://doi.org/10.1016/s0040-4039(01)01287-4
https://doi.org/10.1016/s0040-4039(01)01287-4
Autor:
Cheryl R. Cohen, Susan Y. Tamura, Terence K. Brunck, John Reiner, Odile E. Levy, Ruth F. Nutt, Erick A. Goldman, Jonathan Z. Ho, J. Edward Semple, Peter W. Bergum, Theresa H. Uong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:745-749
A novel series of rigid P3-guanylpiperidine peptide mimics 3-14 was designed as potential factor Xa and prothrombinase inhibitors. Incorporation into a P2-gly-P1-argininal motif led to highly potent and selective inhibitors. The synthesis and biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e072333b45fd50bb0d75fe45a93f76db
https://doi.org/10.1016/s0960-894x(00)00105-0
https://doi.org/10.1016/s0960-894x(00)00105-0
Autor:
Matthew A. Abelman, Erick A. Goldman, J. Edward Semple, Theresa Ha-Uong, Margeurita S. Lim-Wilby, Terence K. Brunck, Susan Y. Tamura, John Reiner, Ruth F. Nutt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:895-900
A novel scaffold for P4-P2 dipeptide mimics containing a rigid pyridone spacer was designed based on a virtual library strategy. Several selected nonpeptidic 4-aralkyl or 4-alkylpyridones incorporating a P1-argininal sequence were prepared. The model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f813f44cdc0c9a18a55cd7f0e39c7b
https://doi.org/10.1016/s0960-894x(99)00102-x
https://doi.org/10.1016/s0960-894x(99)00102-x
Autor:
Terence K. Brunck, Ruth F. Nutt, William C. Ripka, J. Edward Semple, Nathaniel K. Minami, Susan Y. Tamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2421-2426
SAR and molecular modeling investigations on the potent and selective thrombin inhibitor 1b (CVS 1578) and related serine protease inhibitors led to the design of series 2a–g, featuring quaternary α-amino-α-benzyl-lactam scaffolds that serve as n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c4672470844f5a163ae72f03dc3e7a
https://doi.org/10.1016/s0960-894x(97)00446-0
https://doi.org/10.1016/s0960-894x(97)00446-0
Autor:
Robert J. Ardecky, J. Edward Semple, Yu Ge, William C. Ripka, Steven H. Carpenter, Michael I. Weinhouse, Pamela Leon, Brian M. Shamblin, Susan Y. Tamura, Ruth F. Nutt
Publikováno v:
Tetrahedron Letters. 37:4109-4112
A general method for the synthesis of peptidyl argininals was developed which utilizes the novel building block Ng-nitro-L-argininal ethyl aminal·HCl. The final aldehyde structure is generated by hydrolysis of the peptidic aminal moiety and can be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e14882ad2240fe7e76c08fd7ae1282
https://doi.org/10.1016/0040-4039(96)00777-0
https://doi.org/10.1016/0040-4039(96)00777-0
Autor:
Dong-Mei Feng, Daniel F. Veber, Thomas M. Connolly, Mei-Jy Tang, Cindra L. Condra, Ruth F. Nutt
Publikováno v:
Journal of Medicinal Chemistry. 38:4125-4130
The N-terminal thrombin receptor peptide H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH (1) fully activates the thrombin receptor with an EC50 of 10 microM. Structural features in the tetradecapeptide which are responsible for receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7df26681b40bff444666811a07f260
https://doi.org/10.1021/jm00020a029
https://doi.org/10.1021/jm00020a029
Autor:
K.J. Stauffer, Jules A. Shafer, Stephen F. Brady, S. D. Lewis, John T. Sisko, D. F. Veber, Howard Qiu, Assunta S. Ng, Ruth F. Nutt, Michael J. Bogusky, Christiana D. Colton
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:1063-1078
We report structure-activity investigations in a series of tripeptide amide inhibitors of thrombin, and the development of a series of highly potent active site directed α-keto carbonyl inhibitors having the side chain of lysine at P1. Compounds of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f9bc2f83708b3dcd8fa0cec0f08ae3
https://doi.org/10.1016/0968-0896(95)00105-p
https://doi.org/10.1016/0968-0896(95)00105-p
Autor:
Sidney D Lewis, Assunta S Ng, Elizabeth A Lyle, Michael J Mellott, Sandra D Appleby, Stephen F Brady, Kenneth J Stauffer, John T Sisko, Shi-Shan Mao, Daniel F Veber, Ruth F Nutt, Joseph J Lynch, Jacquelynn J Cook, Stephen J Gardll, Jules A Shafer
Publikováno v:
Thrombosis and Haemostasis. 74:1107-1112
SummarySeveral H-N-Me-D-Phe-Pro-Lysyl-α-keto carbonyl derivatives were shown to be potent thrombin inhibitors (Ki 0.2 to 27 nM). The inhibitory potencies of these compounds toward tissue plasminogen activator, plasmin and factor Xa were minimal; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a9f063f2c4aff255d3682a9e5f18f3
https://doi.org/10.1055/s-0038-1649889
https://doi.org/10.1055/s-0038-1649889