Zobrazeno 1 - 10
of 66
pro vyhledávání: '"RUNE E. KUHRE"'
Autor:
Julie M. Jacobsen, Natalia Petersen, Lola Torz, Marina K. Gerstenberg, Kent Pedersen, Søren Østergaard, Birgitte S. Wulff, Birgitte Andersen, Kirsten Raun, Berit Ø. Christoffersen, Linu M. John, Marc L. Reitman, Rune E. Kuhre
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114501- (2024)
Summary: Evaluation of weight loss drugs is usually performed in diet-induced obese mice housed at ∼22°C. This is a cold stress that increases energy expenditure by ∼35% compared to thermoneutrality (∼30°C), which may overestimate drug-induce
Externí odkaz:
https://doaj.org/article/497a3258f3ea4cada07960619cde81b6
Autor:
Thomas D. Madsen, Lasse H. Hansen, John Hintze, Zilu Ye, Shifa Jebari, Daniel B. Andersen, Hiren J. Joshi, Tongzhong Ju, Jens P. Goetze, Cesar Martin, Mette M. Rosenkilde, Jens J. Holst, Rune E. Kuhre, Christoffer K. Goth, Sergey Y. Vakhrushev, Katrine T. Schjoldager
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate p
Externí odkaz:
https://doaj.org/article/d81560792a8349198626ee05e6f9d81f
Autor:
Rune E. Kuhre, Ida M. Modvig, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans
Externí odkaz:
https://doaj.org/article/db177ab402a0435f8ee24eca3d9ff60d
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and appetite, and include cardiovascular benefits and possibly also beneficial eff
Externí odkaz:
https://doaj.org/article/799c69be84d04816aff86ec2416682b3
Autor:
Isabella Jonsson, Kirstine N. Bojsen-Møller, Viggo B. Kristiansen, Simon Veedfald, Nicolai J. Wewer Albrechtsen, Trine R. Clausen, Rune E. Kuhre, Jens F. Rehfeld, Jens J. Holst, Sten Madsbad, Maria S. Svane
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundAltered bile acid (BA) turnover has been suggested to be involved in the improved glucose regulation after Roux-en-Y gastric bypass (RYGB), possibly via stimulation of GLP-1 secretion. We investigated the role of exogenous as well as endoge
Externí odkaz:
https://doaj.org/article/9ac6a7d255d242b4a97a2771e4672a91
Autor:
Marie Winther-Sørensen, Katrine D. Galsgaard, Alberto Santos, Samuel A.J. Trammell, Karolina Sulek, Rune E. Kuhre, Jens Pedersen, Daniel B. Andersen, Anna S. Hassing, Morten Dall, Jonas T. Treebak, Matthew P. Gillum, Signe S. Torekov, Johanne A. Windeløv, Jenna E. Hunt, Sasha A.S. Kjeldsen, Sara L. Jepsen, Catherine G. Vasilopoulou, Filip K. Knop, Cathrine Ørskov, Mikkel P. Werge, Hanne Cathrine Bisgaard, Peter Lykke Eriksen, Hendrik Vilstrup, Lise Lotte Gluud, Jens J. Holst, Nicolai J. Wewer Albrechtsen
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101080- (2020)
Objective: Glucagon is well known to regulate blood glucose but may be equally important for amino acid metabolism. Plasma levels of amino acids are regulated by glucagon-dependent mechanism(s), while amino acids stimulate glucagon secretion from alp
Externí odkaz:
https://doaj.org/article/b7bfa9036b094c1691ac479159a7df74
Autor:
Rune E. Kuhre, Nicolai J. Wewer Albrechtsen, Olav Larsen, Sara L. Jepsen, Emilie Balk-Møller, Daniel B. Andersen, Carolyn F. Deacon, Kristina Schoonjans, Frank Reimann, Fiona M. Gribble, Reidar Albrechtsen, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 84-95 (2018)
Objective: Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative importance and mechanisms involved in BA-stimulated secretion of appetite and meta
Externí odkaz:
https://doaj.org/article/7e8b0269704c40bea7389e41b44cde95
Autor:
Nicolai J. Wewer Albrechtsen, Rune E. Kuhre, Daniel Hornburg, Christian Z. Jensen, Mads Hornum, Carsten Dirksen, Maria Svane, Lærke S. Gasbjerg, Nils B. Jørgensen, Maria N. Gabe, Emilie Balk-Møller, Reidar Albrechtsen, Marie Winther-Sørensen, Katrine D. Galsgaard, Felix Meissner, Tina Jorsal, Asger Lund, Tina Vilsbøll, Rasmus Eliasen, Kirstine N. Bojsen-Møller, Thomas Idorn, Carolyn F. Deacon, Filip K. Knop, Mette M. Rosenkilde, Bolette Hartmann, Bo Feldt-Rasmussen, Matthias Mann, Sten Madsbad, Jens J. Holst
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1452-1460 (2017)
Summary: Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution
Externí odkaz:
https://doaj.org/article/b5aa1694774f4b23bb8fed0e16aceb6a
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Abstract Protein intake robustly stimulates the secretion of the incretin hormone, glucagon‐like peptide‐1 (GLP‐1) but the molecular mechanisms involved are not well understood. In particular, it is unknown whether proteins stimulate secretion
Externí odkaz:
https://doaj.org/article/4cfbc42b17e44eaca684f7a4319c849a
Autor:
Nicolai J. Wewer Albrechtsen, Daniel Hornburg, Reidar Albrechtsen, Berit Svendsen, Signe Toräng, Sara L. Jepsen, Rune E. Kuhre, Marie Hansen, Charlotte Janus, Andrea Floyd, Asger Lund, Tina Vilsbøll, Filip K. Knop, Henrik Vestergaard, Carolyn F. Deacon, Felix Meissner, Matthias Mann, Jens J. Holst, Bolette Hartmann
Publikováno v:
EBioMedicine, Vol 7, Iss C, Pp 112-120 (2016)
Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined mass spectrometry-based platform for identifying and characterizing low-abundance regulatory
Externí odkaz:
https://doaj.org/article/18223ff3e5574a79a867add2c09dfbae