Zobrazeno 1 - 10
of 175
pro vyhledávání: '"RUDOLF MARTINI"'
Autor:
Michaela Hörner, Sandy Popp, Julien Branchu, Giovanni Stevanin, Frédéric Darios, Stephan Klebe, Janos Groh, Rudolf Martini
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
We have previously demonstrated that neuroinflammation by the adaptive immune system acts as a robust and targetable disease amplifier in a mouse model of Spastic Paraplegia, type 11 (SPG11), a complicated form of Hereditary Spastic Paraplegia (HSP).
Externí odkaz:
https://doaj.org/article/b3030858c55f4bb4871901a5455dc32c
Autor:
Janos Groh, Tassnim Abdelwahab, Yogita Kattimani, Michaela Hörner, Silke Loserth, Viktoria Gudi, Robert Adalbert, Fabian Imdahl, Antoine-Emmanuel Saliba, Michael Coleman, Martin Stangel, Mikael Simons, Rudolf Martini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination
Externí odkaz:
https://doaj.org/article/084aa1c4a77d4e9288b6fa63c88f511d
Autor:
Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background Promotion of myelin repair in the context of demyelinating diseases such as multiple sclerosis (MS) still represents a clinical unmet need, given that this disease is not only characterized by autoimmune activities but also by imp
Externí odkaz:
https://doaj.org/article/5baca0a9509e4f5894918ed863c606fa
Autor:
Tassnim Abdelwahab, David Stadler, Konrad Knöpper, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini, Janos Groh
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106698- (2023)
Summary: Myelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by perturbed myelinating gli
Externí odkaz:
https://doaj.org/article/47495b32272d46e79ea05d00e9aeda7d
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immune reactions drives ax
Externí odkaz:
https://doaj.org/article/b8358bf282224f5fb998dc47e1719ab0
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)
Abstract Background Genetically caused neurological disorders of the central nervous system (CNS) are mostly characterized by poor or even fatal clinical outcome and few or no causative treatments are available. Often, these disorders are associated
Externí odkaz:
https://doaj.org/article/6a60363b56cf44b6b0176a98dc66141b
Autor:
Mette R. Rosberg, Susana Alvarez, Dennis Klein, Finn Cilius Nielsen, Rudolf Martini, S. Rock Levinson, Christian Krarup, Mihai Moldovan
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 201-214 (2016)
Mice heterozygously deficient for the myelin protein P0 gene (P0+/−) develop a slowly progressing neuropathy modeling demyelinating Charcot-Marie-Tooth disease (CMT1B). The aim of the study was to investigate the long-term progression of motor dysf
Externí odkaz:
https://doaj.org/article/16df6a58a7ed4ad7a534eea977286963
Autor:
Iria Samper Agrelo, Jessica Schira-Heinen, Felix Beyer, Janos Groh, Christine Bütermann, Veronica Estrada, Gereon Poschmann, Ana Bribian, Janusz J. Jadasz, Laura Lopez-Mascaraque, David Kremer, Rudolf Martini, Hans Werner Müller, Hans Peter Hartung, James Adjaye, Kai Stühler, Patrick Küry
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4350 (2020)
Mesenchymal stem cell (MSC)-secreted factors have been shown to significantly promote oligodendrogenesis from cultured primary adult neural stem cells (aNSCs) and oligodendroglial precursor cells (OPCs). Revealing underlying mechanisms of how aNSCs c
Externí odkaz:
https://doaj.org/article/b99fbf60dc55459592c47522d89a65b6
Autor:
Veronica Estrada, Nicole Brazda, Christine Schmitz, Silja Heller, Heinrich Blazyca, Rudolf Martini, Hans Werner Müller
Publikováno v:
Neurobiology of Disease, Vol 67, Iss , Pp 165-179 (2014)
We identified a suitable biomatrix that improved axon regeneration and functional outcome after partial (moderate) and complete (severe) chronic spinal cord injury (SCI) in rat. Five weeks after dorsal thoracic hemisection injury the lesion scar was
Externí odkaz:
https://doaj.org/article/d1853ff8bfbc47afbae9b28e3fc804d8
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 1, Pp 78-84 (2010)
We have previously shown that in two distinct models for inherited neuropathies of the Charcot-Marie-Tooth (CMT) type, T-lymphocytes are critically involved in demyelination. In the present study, we tested whether T-lymphocytes have a similar pathog
Externí odkaz:
https://doaj.org/article/6828a011c2b2488b944688683b99100f