Zobrazeno 1 - 7
of 7
pro vyhledávání: '"RTK, receptor tyrosine kinases"'
Autor:
Yanfei Cai, Jingyu Zhu, Yun Chen, Jian Jin, Xinling Zhao, Kan Li, Lei Xu, Huazhong Li, Gang Huang
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Graphical abstract
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdbf7fb8f578b72a0c3242e69513c71
https://doi.org/10.1016/j.jare.2021.04.007
https://doi.org/10.1016/j.jare.2021.04.007
Publikováno v:
The Journal of Biological Chemistry
The Golgi apparatus (GA) is a cellular organelle that plays a critical role in the processing of proteins for secretion. Activation of G protein–coupled receptors at the plasma membrane (PM) induces the translocation of G protein βγ dimers to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3110cbbac9c115fca49ea0bece8e9a
http://europepmc.org/articles/PMC7949113
http://europepmc.org/articles/PMC7949113
Autor:
Evi Kostenis, Nicole Merten, Max Crüsemann, Julian Patt, Nina Heycke, Uli Rick, Eva Marie Pfeil, Gabriele M. König, Funda Eryilmaz, Stefan Kehraus, Jan H. Voss, Xavier Deupi, Christa E. Müller, Asuka Inoue, Judith Alenfelder
Publikováno v:
The Journal of Biological Chemistry
Heterotrimeric G protein subunits Gαq and Gα11 are inhibited by two cyclic depsipeptides, FR900359 (FR) and YM-254890 (YM), both of which are being used widely to implicate Gq/11 proteins in the regulation of diverse biological processes. An emergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad14382365f90e4057dbc24db130542
https://doi.org/10.1016/j.jbc.2021.100472
https://doi.org/10.1016/j.jbc.2021.100472
Autor:
Zhanggui Wang, Xinbing Sui, Liangkun You, Jiansheng Xie, Zhao Jing, Hongsen Li, Jiawei Shou, Hongming Pan, Weidong Han
Publikováno v:
Autophagy
Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular homeostasis in response to a series of extracellular insults. However, these insults may trigger the downstream signaling of anot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7370b1766f56b7801df377b10de63140
https://doi.org/10.1080/15548627.2015.1017192
https://doi.org/10.1080/15548627.2015.1017192
Autor:
Edmonds NL; University of Virginia School of Medicine, Charlottesville, Virginia.; Department of Dermatology, University of Virginia, Charlottesville, Virginia., Luu LA; Department of Dermatology, University of Virginia, Charlottesville, Virginia., Guffey DJ; Department of Dermatology, University of Virginia, Charlottesville, Virginia.
Publikováno v:
JAAD case reports [JAAD Case Rep] 2022 Jun 02; Vol. 25, pp. 86-88. Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).
Autor:
Zhu J; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Li K; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Xu L; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, China., Cai Y; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Chen Y; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Zhao X; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China., Li H; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 21412 2, China., Huang G; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China., Jin J; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, China.
Publikováno v:
Journal of advanced research [J Adv Res] 2021 Apr 20; Vol. 36, pp. 1-13. Date of Electronic Publication: 2021 Apr 20 (Print Publication: 2022).