Designing a novel mRNA vaccine against SARS-CoV-2: An immunoinformatics approach

Autor: Ishtiaque Ahammad, Samia Sultana Lira

Publikováno v: International Journal of Biological Macromolecules

SARS-CoV-2 is the deadly virus behind COVID-19, the disease that went on to ravage the world and caused the biggest pandemic 21st century has witnessed so far. On the face of ongoing death and destruction, the urgent need for the discovery of a vacci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352a07660711c1227db925386eb3a8b5
https://doi.org/10.1016/j.ijbiomac.2020.06.213

Antiviral activity of K22 against members of the order Nidovirales

Autor: Volker Thiel, Adriaan H. de Wilde, Julie C. F. Rappe, Margo A. Brinton, Nicolas Ruggli, Philip V'kovski, Hanspeter Stalder, Christin Müller, Eric J. Snijder, Han Di, John Ziebuhr

Publikováno v: Virus Research
Virus Research, 246, 28-34

Highlights • The anti-coronaviral compound K22 has broad antiviral activity against diverse nidoviruses. • K22 treatment reduces double-stranded RNA following nidovirus infection. • K22 displays antiviral activity in nidovirus infection models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8716eba20865e1a2783995e7b783c8d
https://doi.org/10.1016/j.virusres.2018.01.002

CRISPR systems: Novel approaches for detection and combating COVID-19

Autor: Mohammad Afarid, Banafsheh Rastegari, Fatemeh Safari, Mazyar Barekati-Mowahed, Abbas Behzad-Behbahani, Afshin Borhani-Haghighi

Publikováno v: Virus Research

Highlights • SARS-CoV-2 has infected millions people worldwide with numerous deaths since December 2019. • Type V and VI CRISPR enzymes are efficient agents for diagnosis and combating single-stranded RNA viruses such as SARS-CoV-2. • DETECTR a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1a6620c3b2fa0a7213b24d7298d7da
https://doi.org/10.1016/j.virusres.2020.198282

In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors

Autor: Gurung, Arun Bahadur

Publikováno v: Gene Reports

The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals. SARS-CoV-2 relies on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59819417a63124b98e4c37f0b5efbc6c
https://doi.org/10.1016/j.genrep.2020.100860

Glycyrrhizin as a promising kryptonite against SARS-CoV-2: Clinical, experimental, and theoretical evidences.

Autor: Banerjee S; Department of Pharmaceutical Technology, Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Jadavpur University, P.O. Box 17020, Kolkata, West Bengal 700032, India., Baidya SK; Department of Pharmaceutical Technology, Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Jadavpur University, P.O. Box 17020, Kolkata, West Bengal 700032, India., Adhikari N; Department of Pharmaceutical Technology, Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Jadavpur University, P.O. Box 17020, Kolkata, West Bengal 700032, India., Ghosh B; Department of Pharmacy, Epigenetic Research Laboratory, Birla Institute of Technology and Science-Pilani, Hyderabad Campus, Shamirpet, Hyderabad 500078, India., Jha T; Department of Pharmaceutical Technology, Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Jadavpur University, P.O. Box 17020, Kolkata, West Bengal 700032, India.

Publikováno v: Journal of molecular structure [J Mol Struct] 2023 Mar 05; Vol. 1275, pp. 134642. Date of Electronic Publication: 2022 Nov 25.