Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials

Autor: de Haan, Rosemarie, Pluim, Dick, van Triest, Baukelien, van den Heuvel, Michel, Peulen, Heike, van Berlo, Damien, George, Jay, Verheij, Marcel, Schellens, Jan H M, Vens, Conchita, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

Publikováno v: Radiotherapy and Oncology, 126(3), 443-449. Elsevier Ireland Ltd
Radiotherapy and Oncology, 126, 443-449
de Haan, R, Pluim, D, van Triest, B, van den Heuvel, M, Peulen, H, van Berlo, D, George, J, Verheij, M, Schellens, J H M & Vens, C 2018, ' Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials ', Radiotherapy and Oncology, vol. 126, no. 3, pp. 443-449 . https://doi.org/10.1016/j.radonc.2017.10.017
Radiotherapy and Oncology, 126, 3, pp. 443-449
Radiotherapy and Oncology, 126(3), 443. Elsevier Ireland Ltd.

Item does not contain fulltext BACKGROUND: PARP inhibitors are currently evaluated in combination with radiotherapy and/or chemotherapy. As sensitizers, PARP inhibitors are active at very low concentrations therefore requiring highly sensitive pharma

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https://hdl.handle.net/1874/375266