Zobrazeno 1 - 6
of 6
pro vyhledávání: '"RSPO2 Gene"'
Autor:
Volker Endris, Thomas Longerich, Benedikt Brors, Andreas Rosenwald, Beate K. Straub, Mark Kriegsmann, Zahra Abadi, R Pellegrino, Falko Schulze, Olaf Neumann, Ludwig Wilkens, Martina Kirchner, Arianeb Mehrabi, Peter Schirmacher, Stefan Froehling, Jan Budczies, Karl Heinz Weiss, Sebastian Uhrig, Kai Breuhahn, Tim Frederik Weber, Albrecht Stenzinger, Eugen Rempel
Publikováno v:
Gut. 68:1287-1296
ObjectiveWe aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC).DesignLarge cohorts of HCA (n=185) and HCC (
Autor:
Yong-Ri Jin, Xiang Hua Han, Katsuhiko Nishimori, Dan Ben-Avraham, Youn Jeong Oh, Jae-won Shim, Jeong Kyo Yoon
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
The R-spondin (RSPO) family of proteins potentiate canonical WNT/β-catenin signaling and may provide a mechanism to fine-tune the strength of canonical WNT signaling. Although several in vitro studies have clearly demonstrated the potentiation of ca
Autor:
Volker Endris, Arianeb Mehrabi, Jan Budczies, Tim Frederik Weber, Mark Kriegsmann, Andreas Rosenwald, Sebastian Uhrig, Eugen Rempel, Karl-Heinz Weiss, Peter Schirmacher, Thomas Longerich, Olaf Neumann, A. Stenzinger, F Schulze, Beate K. Straub
Publikováno v:
35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber.
Publikováno v:
Gut
Gut, BMJ Publishing Group, 2020, 69 (6), pp.1152-1153. ⟨10.1136/gutjnl-2019-319089⟩
Gut, 2020, 69 (6), pp.1152-1153. ⟨10.1136/gutjnl-2019-319089⟩
Gut, BMJ Publishing Group, 2020, 69 (6), pp.1152-1153. ⟨10.1136/gutjnl-2019-319089⟩
Gut, 2020, 69 (6), pp.1152-1153. ⟨10.1136/gutjnl-2019-319089⟩
International audience; Thomas Longerich and collaborators1 recently published an intriguing observation in hepatocellular adenoma (HCA) showing an activation of the Wnt/ß-catenin signalling pathway without CTNNB1 or APC mutations. The authors ident
Publikováno v:
Journal of Biological Chemistry. 286:10649-10659
R-spondins (RSPOs) are a recently characterized family of secreted proteins that activate WNT/β-catenin signaling. In this study, we investigated the potential roles of the RSPO proteins during myogenic differentiation. Overexpression of the Rspo1 g
Publikováno v:
Journal of Ovarian Research.
R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient