Zobrazeno 1 - 10
of 15
pro vyhledávání: '"RSK, ribosomal S6 kinase"'
Autor:
Carretero, Luis a, 1, Llavona, Pablo a, 2, López-Hernández, Alejandro a, 3, Casado, Pedro b, Cutillas, Pedro R. b, de la Peña, Pilar a, Barros, Francisco a, Domínguez, Pedro a, ⁎
Publikováno v:
In Cellular Signalling September 2015 27(9):1720-1730
Autor:
Jane E. Cavanaugh, Patrick T. Flaherty, Lucio Miele, Margarite D. Matossian, Thomas D. Wright, Van Barnes, Matthew E. Burow, Deniz A. Ucar, Suravi Chakrabarty, Akshita B. Bhatt, Erin Lexner
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 6, Pp 101046-(2021)
Translational Oncology, Vol 14, Iss 6, Pp 101046-(2021)
Highlights • ERK1/2 and ERK5 pathway inhibition induces mesenchymal to epithelial transition in breast cancer. • ERK5 is endogenously active and localized in the nucleus of TNBC cells. • Dual ERK5 and ERK1/2 or AKT inhibition is a relevant stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae42aa562776ae0dc9e5bd5217344a1a
https://lirias.kuleuven.be/handle/20.500.12942/707698
https://lirias.kuleuven.be/handle/20.500.12942/707698
Autor:
Masamitsu Gotou, Hideo Baba, Yuji Baba, Yoji Sagiya, Junpei Soeda, Hiroshi Sawada, Yukiko Hikichi, Hiroya Taniguchi, Kazuhide Nakamura, Ikuo Mori, Kazunori Yamanaka, Yukiko Sakakibara
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 668-677 (2018)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 668-677 (2018)
Recent studies in RAS wild-type (WT) metastatic colorectal cancer (mCRC) suggest that the survival benefits of therapy using anti-epidermal growth factor receptor (anti-EGFR) and anti-vascular endothelial growth factor (anti-VEGF) antibodies combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4927ea291e0fdbe4b6a6867f83d66
http://europepmc.org/articles/PMC6030230
http://europepmc.org/articles/PMC6030230
Autor:
Graeme Nixon, Fiona H. Greig
Publikováno v:
Pharmacology & Therapeutics
Phosphoprotein enriched in astrocytes-15 (PEA-15) is a cytoplasmic protein that sits at an important junction in intracellular signalling and can regulate diverse cellular processes, such as proliferation and apoptosis, dependent upon stimulation. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd51792c95b568dbc8829ce0ba4c22fd
https://doi.org/10.1016/j.pharmthera.2014.03.006
https://doi.org/10.1016/j.pharmthera.2014.03.006
Autor:
Natalia Shpiro, Maria Stella Ritorto, Kei Sakamoto, Dario R. Alessi, Vanessa P. Houde, Robert Gourlay, Joby Varghese, Paul Davies
Publikováno v:
Biochemical Journal
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe36ddd49d60988f3b36857bd507191
https://doi.org/10.1042/bj20131324
https://doi.org/10.1042/bj20131324
Publikováno v:
Biochemical Journal
ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9ea954d433660d58ba0f0f41fde7cd
http://europepmc.org/articles/PMC3573779
http://europepmc.org/articles/PMC3573779
Autor:
Carol MacKintosh, David G. Campbell, Sandra Crowther, Margaret J. Stafford, Rachel Toth, Catherine Johnson
Publikováno v:
Biochemical Journal
More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3-3/phosphoprotein networks work. Mode I RXX(pS/pT)XP motifs d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233aa1db83f31d992236e3066a26f892
https://doi.org/10.1042/bj20091834
https://doi.org/10.1042/bj20091834
Autor:
Dario R. Alessi, Jennifer Moran, Alexander Gray, Christine M. Chresta, Sabina Cosulich, Juan M. García-Martínez, Rosemary G. Clarke
Publikováno v:
Biochemical Journal
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein kinase C) family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 kinase) and SGK (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2954c6be093252396b73728152492aed
https://doi.org/10.1042/bj20090489
https://doi.org/10.1042/bj20090489
Autor:
Boris N. Kholodenko, Natalia Volinsky, Cormac McCarthy, Nina Saban, Mariko Okada-Hatakeyama, Alex von Kriegsheim, Walter Kolch
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 35, Iss 2, p e00178 (2015)
Bioscience Reports, Vol 35, Iss 2, p e00178 (2015)
In MCF-7 breast cancer cells epidermal growth factor (EGF) induces cell proliferation, whereas heregulin (HRG)/neuregulin (NRG) induces irreversible phenotypic changes accompanied by lipid accumulation. Although these changes in breast cancer cells r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ef4589932267100ca4347d61ac0ead
https://doi.org/10.1042/bsr20140172
https://doi.org/10.1042/bsr20140172
Autor:
Björn Brembs
Publikováno v:
Current Opinion in Neurobiology. 13:710-717
Learning to anticipate future events on the basis of past experience with the consequences of one’s own behavior (operant conditioning) is a simple form of learning that humans share with most other animals, including invertebrates. Three model org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b0754ca3a4fa3970c6573d3647d33d
https://doi.org/10.1016/j.conb.2003.10.002
https://doi.org/10.1016/j.conb.2003.10.002