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pro vyhledávání: '"RS-102221"'
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Publikováno v:
eNeuro
Previous research has indicated that reward-paired cues can enhance disadvantageous risky choice in both humans and rodents. Systemic administration of a serotonin 2C receptor antagonist can attenuate this cue-induced risk preference in rats. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cb8860e1ede2a5a77adad8112cf491
https://pubmed.ncbi.nlm.nih.gov/34815296
https://pubmed.ncbi.nlm.nih.gov/34815296
Autor:
Guadalupe C. Vidal-Cantú, Beatriz Godínez-Chaparro, Vinicio Granados-Soto, Claudia Cervantes-Durán
Publikováno v:
Pharmacological Reports. 68:434-442
Background The purpose of this study was to determine the role of spinal 5-HT 2A , 5-HT 2B and 5-HT 2C receptors in the development and maintenance of formalin-induced long-lasting secondary allodynia and hyperalgesia in rats, as well as their expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b51d91beed5ad243ca2a6debc885846
https://doi.org/10.1016/j.pharep.2015.11.009
https://doi.org/10.1016/j.pharep.2015.11.009
Publikováno v:
Behavioral Neuroscience. 123:1046-1057
Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93643a1e8efaa9a9e18274bfc124cea
https://doi.org/10.1037/a0016882
https://doi.org/10.1037/a0016882
Autor:
Enrico Bracci, Craig Blomeley
Publikováno v:
The European Journal of Neuroscience
Fast-spiking interneurons (FSIs) control the output of the striatum by mediating feed-forward GABAergic inhibition of projection neurons. Their neuromodulation can therefore critically affect the operation of the basal ganglia. We studied the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d85f6aab0e8826bfd43ba6d8176b141
http://europepmc.org/articles/PMC2695856
http://europepmc.org/articles/PMC2695856
Publikováno v:
Bulletin of Experimental Biology and Medicine. 142:76-79
Injection of RS 102221 (selective antagonist of serotonin 5-HT2C receptors) in a dose of 2 mg/kg reduced anxiety of mice in the light-darkness test and decreased the amplitude of the startle reflex. RS 102221 in a dose of 1 mg/kg reduced prestimulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d03a157534d8c9b009684423f081768
https://doi.org/10.1007/s10517-006-0296-8
https://doi.org/10.1007/s10517-006-0296-8
Autor:
Masahiro Irifune, Katsuya Morita, Masahiro Hamamoto, Toshihiro Dohi, Shigeaki Arai, Michio Kawahara, Kenji Kihira, Shigeo Kitayama
Publikováno v:
Brain Research. 1057:153-160
The present study examined whether the inhibition of serotonin transporters (SERT) contributes to cocaine- and other local anesthetics-induced convulsions, and which subtypes of 5-HT receptor are involved in the convulsions. For this purpose, cocaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaf2c568f79875a27be24bab869cb8d
https://doi.org/10.1016/j.brainres.2005.07.049
https://doi.org/10.1016/j.brainres.2005.07.049
Publikováno v:
Neuropsychopharmacology. 30:2180-2191
Akin to what has been reported for cocaine, systemic administration of the dopamine D1 receptor antagonist, SCH 23390 ((R)-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride), blocks the expression but not the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7d1104b1e71a2541666f27ea763b4a
https://doi.org/10.1038/sj.npp.1300735
https://doi.org/10.1038/sj.npp.1300735
Autor:
Gal Yadid, David H. Overstreet, Michael E. Newman, Noa Kinor, Eliyahu Dremencov, Cheryl J. Schindler, Gitit Blatman-Jan
Publikováno v:
Neuropharmacology. 48:34-42
Dopamine release in the nucleus accumbens mediates motivation and reward, making it a likely candidate to be involved in anhedonia, one of the major symptoms of depression. In the current study, alterations in basal extracellular dopamine levels and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1652253dec42f83225e18be5a80656c9
https://doi.org/10.1016/j.neuropharm.2004.09.013
https://doi.org/10.1016/j.neuropharm.2004.09.013
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:734-743
The serotonin2C (5-hydroxytryptamine2C; 5-HT2C) receptor (5-HT2CR) is found in abundance in dopamine (DA) mesocorticolimbic pathways and is one of the important target proteins that modulates the behavioral effects of cocaine. In the present study, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf5d5144ed7df9a015d1b564a6f9f8d
https://doi.org/10.1124/jpet.102.045716
https://doi.org/10.1124/jpet.102.045716