Zobrazeno 1 - 10 of 763 pro vyhledávání: '"RPE, retinal pigment epithelial"'
1
A vicious cycle of bisretinoid formation and oxidation relevant to recessive Stargardt disease
Autor: Hye Jin Kim, Joshua L. Dunaief, Keiko Ueda, Janet R. Sparrow, Diego Montenegro, Jin Zhao, Kevin Zhang
Publikováno v: The Journal of Biological Chemistry
The ability of iron to transfer electrons enables the contribution of this metal to a variety of cellular activities even as the redox properties of iron are also responsible for the generation of hydroxyl radicals (•OH), the most destructive of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba35195fd6a8c8394dc2511e49becd4c
https://pubmed.ncbi.nlm.nih.gov/33402423
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2
Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications
Autor: Liyuan Cao, Wei Mu
Publikováno v: Pharmacological Research
Graphical abstract
Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b673f8b687ffb866bd8f37e46b2c624
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3
Lipid metabolism dysregulation in diabetic retinopathy
Autor: Julia V. Busik
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100017-(2021)
Lipid metabolic abnormalities have emerged as potential risk factors for the development and progression of diabetic complications, including diabetic retinopathy (DR). This review article provides an overview of the results of clinical trials evalua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6aa493f8d593c77dc82258108941d4a
https://pubmed.ncbi.nlm.nih.gov/33581416
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4
Oxidative stress induces Z-DNA-binding protein 1–dependent activation of microglia via mtDNA released from retinal pigment epithelial cells
Autor: Jamal Saada, Ryan J. McAuley, Michela Marcatti, Tony Zifeng Tang, Massoud Motamedi, Bartosz Szczesny
Publikováno v: The Journal of Biological Chemistry
Oxidative stress, inflammation, and aberrant activation of microglia in the retina are commonly observed in ocular pathologies. In glaucoma or age-related macular degeneration, the chronic activation of microglia affects retinal ganglion cells and ph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6155e8a22f65e20ca59d4f81e0fe350e
https://doi.org/10.1016/j.jbc.2021.101523
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5
Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration
Autor: Mehat, Manjit S, Sundaram, Venki, Ripamonti, Caterina, Robson, Anthony G, Smith, Alexander J, Borooah, Shyamanga, Robinson, Martha, Rosenthal, Adam N, Innes, William, Weleber, Richard G, Lee, Richard W J, Crossland, Michael, Rubin, Gary S, Dhillon, Baljean, Steel, David H W, Anglade, Eddy, Lanza, Robert P, Ali, Robin R, Michaelides, Michel, Bainbridge, James W B
Publikováno v: Ophthalmology
Mehat, M S, Sundaram, V, Ripamonti, C, Robson, A G, Smith, A J, Borooah, S, Robinson, M, Rosenthal, A N, Innes, W, Weleber, R G, Lee, R W J, Crossland, M, Rubin, G S, Dhillon, B, Steel, D H W, Anglade, E, Lanza, R P, Ali, R R, Michaelides, M & Bainbridge, J W B 2018, ' Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration ', Ophthalmology: Journal of The American Academy of Ophthalmology . https://doi.org/10.1016/j.ophtha.2018.04.037
PURPOSE: Transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells offers the potential for benefit in macular degeneration. Previous trials have reported improved visual acuity (VA), but lacked detailed analy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::afba1d8ecfc283050a42387f7d7f2215
http://europepmc.org/articles/PMC6195794
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6
Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene
Autor: Hiroki Tsujinaka, Maiko Takeda, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Asako Itaya-Hironaka, Nahoko Ogata, Takanori Fujimura, Hiroyo Ota, Shin Takasawa
Publikováno v: Biochemistry and Biophysics Reports
Although recent research showed that advanced glycation endproduct (AGE) and hydroquinone (HQ) are related to the pathogenesis of age-related macular degeneration (AMD), the mechanism how AGE and HQ induce or accelerate AMD remains elusive. In the pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3b794b2136a4b27338d99bf6e72509
https://doi.org/10.1016/j.bbrep.2015.05.005
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7
PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases
Autor: Rui Cheng, Siribhinya Benyajati, Jian Xing Ma, Xuemin He
Publikováno v: Clinical Science (London, England : 1979)
Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles in many physiological and pathophysiological processes, includ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f0eb505cdd8e879711ecfdef97aa4c
http://europepmc.org/articles/PMC4557399
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8
Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
Autor: Eiichi Okada, Yusuke Murakami, Tsutomu Yasukawa, Yasuhiro Ikeda, Yasuo Yanagi, Khandakar A.S.M. Saadat, Yoko Nomura, Xue Tan
Publikováno v: FEBS Open Bio, Vol 4, Iss C, Pp 1007-1014 (2014)
FEBS Open Bio
Highlights • Autophagy was augmented in RPE cells in the presence of a lipofuscin pigment, A2E. • RPE cell death was induced in the presence of A2E with an autophagy inhibitor. • Inhibition of autophagy resulted in the accumulation of abnormal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5b65dabb701ddfa6e98a83b3adcc15
https://doi.org/10.1016/j.fob.2014.11.003
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9
Akademický článek
Retinal Layer and Choroidal Changes in Deep and Scuba Divers: Evidence of Pachychoroid Spectrum‐Like Findings.
Autor: Demir, Nur1 (AUTHOR) nurd9920@gmail.com, Kayhan, Belma1 (AUTHOR), Acar, Mertan2 (AUTHOR), Sevincli, Sukru1 (AUTHOR), Sonmez, Murat1 (AUTHOR), Iovino, Claudio (AUTHOR)
Publikováno v: Journal of Ophthalmology. 11/15/2024, Vol. 2024, p1-8. 8p.
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10
Akademický článek
Insights to Ang/Tie signaling pathway: another rosy dawn for treating retinal and choroidal vascular diseases.
Autor: Sha, Lulu1,2 (AUTHOR), Zhao, Yameng1,2 (AUTHOR), Li, Siyu2 (AUTHOR), Wei, Dong2 (AUTHOR), Tao, Ye1 (AUTHOR) panghtoyezz@zzu.edu.cn, Wang, Yange1 (AUTHOR) wangyange123@zzu.edu.cn
Publikováno v: Journal of Translational Medicine. 10/4/2024, Vol. 22 Issue 1, p1-23. 23p.
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