Zobrazeno 1 - 10
of 105
pro vyhledávání: '"RP Maguire"'
Autor:
Klaus L. Leenders, Valtteri Kaasinen, M. Koning, Marije van Beilen, A. T. Portman, RP Maguire, Jan Pruim, Henk A.L. Kiers
Publikováno v:
Parkinsonism & Related Disorders, 14(3), 224-228. Elsevier
This study sought to determine the nature of the relationship between cognition and striatal dopaminergic functioning in 28 patients with advanced Parkinson's disease (PD) using fluorodopa Positron emission tomography (FDOPA-PET) and neuropsychologic
Autor:
Harri Merisaari, RP Maguire, Kjell Någren, Lauri T. Haltia, Semi Helin, Eriika Savontaus, Juha O. Rinne, Valtteri Kaasinen
Publikováno v:
Synapse, 61(9), 748-756. WILEY-LISS
Dopamine is known to regulate food intake by modulating food reward via the mesolimbic circuitry of the brain. The objective of this study was to compare the effects of high energy input (i.v. glucose) on striatal and thalamic dopamine release in ove
Publikováno v:
Brain Research, 1081, 179-190. ELSEVIER SCIENCE BV
Using functional magnetic resonance imaging (fMRI), we examined the distribution of cerebral activations related to implicitly learning a series of fixed stimulus-response combinations. In a novel - bimanual - variant of the Serial Reaction Time task
Autor:
A. T. Portman, V. Sturm, Michiel J. Staal, RP Maguire, L. Burghaus, Klaus L. Leenders, A. Koulousakis, Karl Herholz, Wolf-Dieter Heiss, Rüdiger Hilker, Jan Pruim, T. van Laar, J. Voges, B. M. de Jong
Publikováno v:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 76(9), 1217-1221. BMJ PUBLISHING GROUP
Objectives: Glutamate mediated excitotoxicity of the hyperactive subthalamic nucleus (STN) has been reported to contribute to nigral degeneration in Parkinson's disease (PD). Deep brain stimulation of the STN (STN DBS), in its role as a highly effect
Publikováno v:
Journal of medical primatology, 33(2), 78-82
Pharmacokinetic modelling of radiotracers for positron emission tomography (PET) imaging of neuroreceptors can be performed with time-activity data for brain and blood. We aimed to develop an alternative to withdrawal of arterial blood samples for ac
Publikováno v:
Journal of Neural Transmission, 111(4), 497-509. SPRINGER WIEN
Patients with Parkinson's disease (PD) and levodopa-induced motor complications experience a short-duration response (SDR) to levodopa which can be considered the basis of motor fluctuations. The SDR is characterized by reduced response duration, inc
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 259:277-280
In the 'normal' ageing brain a decrease in the cerebral metabolic rate has been determined across many brain regions. This study determines whether age differences would affect metabolic rates in regions and different hemispheres of the brain. The re
Publikováno v:
Physiological Measurement, 24(2):PII S0967-3334(03)53037-4, 237-249. IOP PUBLISHING LTD
A simple pharmacokinetic model to explain the time course of [O-15] water in human whole blood after bolus injection is described. The model has been derived from measurements in twelve healthy volunteers who were measured repeatedly, resulting in 67
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 249:455-460
Brain tissue samples, obtained from the Alzheimer Disease Brain Bank,Institute of Psychiatry, London, were taken from both left and right hemispheresof three regions of the cerebrum, namely the frontal, parietal and occipitallobes for both Alzheimer
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 244:179-184
Alzheimer's disease (AD) is a debilitating form of dementia which leads to impaired memory, thinking and behavior. This work examines elemental concentrations between "normal" and AD subjects as well as the hemispherical differences within the brain.