Circadian time series proteomics reveals daily dynamics in cartilage physiology.

Autor: Dudek M; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Angelucci C; Murdoch Children's Research Institute and University of Melbourne, Parkville, Victoria, Australia., Pathiranage D; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Wang P; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Mallikarjun V; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Lawless C; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Swift J; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Kadler KE; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Boot-Handford RP; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK., Hoyland JA; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Biomedical Research Centre, Central Manchester Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom., Lamande SR; Murdoch Children's Research Institute and University of Melbourne, Parkville, Victoria, Australia., Bateman JF; Murdoch Children's Research Institute and University of Melbourne, Parkville, Victoria, Australia., Meng QJ; Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK. Electronic address: qing-jun.meng@manchester.ac.uk.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2021 May; Vol. 29 (5), pp. 739-749. Date of Electronic Publication: 2021 Feb 19.

Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis.

Autor: Kung LHW; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.; Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia., Mullan L; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK., Soul J; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK.; Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK., Wang P; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK., Mori K; Department of Biophysics, Graduate School of Science, and Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, 606-8502, Japan., Bateman JF; Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia., Briggs MD; Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK., Boot-Handford RP; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, UK. Ray.Boot-Handford@manchester.ac.uk.

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2019 Sep 11; Vol. 21 (1), pp. 206. Date of Electronic Publication: 2019 Sep 11.

SkeletalVis: an exploration and meta-analysis data portal of cross-species skeletal transcriptomics data.

Autor: Soul J; Division of Evolution & Genomic Sciences, University of Manchester, Manchester, MUK.; Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, Faculty of Biology Medicine and Health, University of Manchester, Manchester, MUK., Hardingham TE; Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, Faculty of Biology Medicine and Health, University of Manchester, Manchester, MUK., Boot-Handford RP; Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, Faculty of Biology Medicine and Health, University of Manchester, Manchester, MUK., Schwartz JM; Division of Evolution & Genomic Sciences, University of Manchester, Manchester, MUK.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2019 Jul 01; Vol. 35 (13), pp. 2283-2290.

Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis.

Autor: Bell PA; Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK.; Centre for Blood Research, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada., Dennis EP; Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK.; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester, M13 9PT, UK., Hartley CL; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.; Genomic Diagnostics Laboratory, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WL, UK., Jackson RM; Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK., Porter A; Newcastle University Protein and Proteome Analysis Facility, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Boot-Handford RP; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester, M13 9PT, UK., Pirog KA; Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK. katarzyna.pirog@ncl.ac.uk., Briggs MD; Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK.; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

Publikováno v: Cell stress & chaperones [Cell Stress Chaperones] 2019 Jan; Vol. 24 (1), pp. 159-173. Date of Electronic Publication: 2018 Dec 12.

ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome.

Autor: Mularczyk EJ; Wellcome Centre for Cell Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK.; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Singh M; Wellcome Centre for Cell Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK.; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Godwin ARF; Wellcome Centre for Cell Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK.; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Galli F; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Humphreys N; School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Adamson AD; School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Mironov A; School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Cain SA; Wellcome Centre for Cell Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK.; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Sengle G; Center for Biochemistry, Center for Molecular Medicine (CMMC), Medical Faculty, University of Cologne, Germany., Boot-Handford RP; Wellcome Centre for Cell Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK.; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Cossu G; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Kielty CM; Wellcome Centre for Cell Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK.; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK., Baldock C; Wellcome Centre for Cell Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, UK.; Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2018 Nov 01; Vol. 27 (21), pp. 3675-3687.