Zobrazeno 1 - 10
of 164
pro vyhledávání: '"RORY B. CONOLLY"'
Publikováno v:
Toxics, Vol 10, Iss 11, p 700 (2022)
Humans are exposed to persistent organic pollutants, such as dioxin-like compounds (DLCs), as mixtures. Understanding and predicting the toxicokinetics and thus internal burden of major constituents of a DLC mixture is important for assessing their c
Externí odkaz:
https://doaj.org/article/2d3e503f999548f29ab57fbb2c9ac42f
Publikováno v:
Frontiers in Public Health, Vol 6 (2018)
Chemical toxicity testing is moving steadily toward a human cell and organoid-based in vitro approach for reasons including scientific relevancy, efficiency, cost, and ethical rightfulness. Inferring human health risk from chemical exposure based on
Externí odkaz:
https://doaj.org/article/08822b84194c4648b9825d174b5b2f76
Publikováno v:
Dose-Response, Vol 10 (2012)
The shape of dose response of ionizing radiation (IR) induced cancer at low dose region, either linear non-threshold or J-shaped, has been a debate for a long time. This dose response relationship can be influenced by built-in capabilities of cells t
Externí odkaz:
https://doaj.org/article/70067ad8b9bd4876abed0c22ade7a17a
Autor:
Rory B Conolly, Jeffry Schroeter, Julia S Kimbell, Harvey Clewell, Melvin E Andersen, P Robinan Gentry
Publikováno v:
Toxicological Sciences. 193:1-17
Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC). This outcome is well-characterized: including dose-response and time course data for SCC, mechanistic endpoints, and nasal dosimetry. Conolly et al. (Toxicol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ff9a35902172063ef6228b4684274b
https://doi.org/10.1093/toxsci/kfad028
https://doi.org/10.1093/toxsci/kfad028
Autor:
Rory B, Conolly, Jerry L, Campbell, Harvey J, Clewell, Jeffry, Schroeter, Julia S, Kimbell, P Robinan, Gentry
Publikováno v:
Toxicological Sciences. 191:15-24
Understanding the dose-response for formaldehyde-induced nasal cancer in rats is complicated by (1) the uneven distribution of inhaled formaldehyde across the interior surface of the nasal cavity and, (2) the presence of endogenous formaldehyde (endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde6602d72d410cbfe9162760058e888
https://doi.org/10.1093/toxsci/kfac119
https://doi.org/10.1093/toxsci/kfac119
Autor:
Daniel L. Villeneuve, Brett R. Blackwell, Chad A. Blanksma, Jenna E. Cavallin, Wan‐Yun Cheng, Rory B. Conolly, Kendra Conrow, David J. Feifarek, Larry J. Heinis, Kathleen M. Jensen, Michael D. Kahl, Rebecca Y. Milsk, Shane T. Poole, Eric C. Randolph, Travis W. Saari, Karen H. Watanabe, Gerald T. Ankley
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 42(1)
To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach methodologies (NAMs) that provide relevant scientific information at a quality equivalent to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abec59100887e4e6dc1e05f3bac264aa
https://pubmed.ncbi.nlm.nih.gov/36282016
https://pubmed.ncbi.nlm.nih.gov/36282016
Publikováno v:
Environmental Science & Technology. 53:11002-11012
Exposure to environmental contaminants can lead to adverse outcomes in both human and nonhuman receptors. The Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) frameworks can mechanistically inform cumulative risk assessment for huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b15ca4262c6e5c40edb6d37cd8f83f
https://doi.org/10.1021/acs.est.9b04639
https://doi.org/10.1021/acs.est.9b04639
Autor:
Rory B. Conolly, Thomas A. Hill
Publikováno v:
Toxicological Sciences. 172:1-10
Traditional methods for carcinogenicity testing rely heavily on the rodent bioassay as the standard for identification of tumorigenic risk. As such, identification of species-specific outcomes and/or metabolism are a frequent argument for regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d8e4dd9b8db569edef2eca49c9d4cf
https://doi.org/10.1093/toxsci/kfz185
https://doi.org/10.1093/toxsci/kfz185
Autor:
Sudin Bhattacharya, Melvin E. Andersen, Jingbo Pi, W. Michael Caudle, Norbert E. Kaminski, Qiang Zhang, Rory B. Conolly
Publikováno v:
Curr Opin Toxicol
As systems biology expands its multi-omic spectrum to increasing resolutions, distinguishing cells based on single-cell profiles becomes feasible. Unlike traditional bulk assays that average cellular responses and blur the distinct identities of resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd29f06a20e772b2d0db160fd82d82f5
https://doi.org/10.1016/j.cotox.2019.04.003
https://doi.org/10.1016/j.cotox.2019.04.003
Autor:
Stephanie Padilla, W. Kyle Martin, Wayne E. Cascio, Michael D. Hays, David M. DeMarini, M. Ian Gilmour, Joey S Stevens, Katya M. Prince, Aimen K. Farraj, Rory B. Conolly, Leslie C. Thompson, Alan H. Tennant, Brandi L Martin, Mehdi S. Hazari
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Heart rate assays in wild-type zebrafish embryos have been limited to analysis of one embryo per video/imaging field. Here we present for the first time a platform for high-throughput derivation of heart rate from multiple zebrafish (Danio rerio) emb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98291a8d22945e9c97d80e4ad1f3857a
http://link.springer.com/article/10.1038/s41598-018-35949-5
http://link.springer.com/article/10.1038/s41598-018-35949-5