Levels of circulating tumor DNA correlate with tumor volume in gastro‐intestinal stromal tumors: an exploratory long‐term follow‐up study

Autor: Roos F. Bleckman, Charlotte M. S. C. Haag, Naomi Rifaela, Gerrieke Beukema, Ron H. J. Mathijssen, Neeltje Steeghs, Hans Gelderblom, Ingrid M. E. Desar, Arjen Cleven, Arja terElst, Ed Schuuring, Anna K. L. Reyners

Publikováno v: Molecular Oncology, Vol 18, Iss 11, Pp 2658-2667 (2024)

Patients with gastro‐intestinal stromal tumors (GISTs) undergoing tyrosine kinase inhibitor therapy are monitored with regular computed tomography (CT) scans, exposing patients to cumulative radiation. This exploratory study aimed to evaluate circu

Externí odkaz: https://doaj.org/article/24846d9179084dad86b3bdbabda1dee8

A multicentric, randomized, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children—BENEFICIAL trial

Autor: Pieter A. De Cock, Roos Colman, Anca Amza, Peter De Paepe, Hans De Pla, Lieselot Vanlanduyt, Dimitri Van der Linden, the Beneficial Trial Consortium

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-24 (2024)

Abstract Background Vancomycin is a commonly prescribed antibiotic to treat serious Gram-positive infections in children. The efficacy of vancomycin is known to be directly related to the pharmacokinetic/pharmacodynamic (PK/PD) index of the area unde

Externí odkaz: https://doaj.org/article/863e04f58ffe40869fb6f84dbeb1bc12

Evaluation of a group-based online informed consent conversation (eConsent) in participants from a low-risk vaccination clinical trial

Autor: Ngoc H. Tan, Melvin Lafeber, Roos S. G. Sablerolles, Isabelle Veerman Roders, Anna van de Hoef, Karenin van Grafhorst, Leo G. Visser, Douwe F. Postma, Abraham Goorhuis, Wim J. R. Rietdijk, P. Hugo M. van der Kuy

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-8 (2024)

Abstract Background Electronic informed consent (eConsent) usage has expanded in recent years in Europe, especially during the pandemic. Slow recruitment rate and limitations in participant outreach are the challenges often faced in clinical research

Externí odkaz: https://doaj.org/article/f9ff3defdbea4d9dbc89791a2492116c

The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust

Autor: Ashwin V. Venkataraman, Pooja Kandangwa, Roos Lemmen, Rutvi Savla, Mazda Beigi, Devon Hammond, Daniel Harwood, Justin Sauer, Latha Velayudhan, Clive Ballard, Anna-Katharine Brem, Chris Kalafatis, Dag Aarsland

Publikováno v: BJPsych Open, Vol 11 (2025)

Background The novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI). Aims To describe t

Externí odkaz: https://doaj.org/article/560bbff5b37c407ca3387431bbd10de0

Association between Clinical Frailty Scale and mortality 24 months after hospitalisation in adult patients with COVID-19

Autor: Julia Minnema, Melvin Lafeber, Roos S.G. Sablerolles, Janneke A.L. van Kempen, Lisanne Tap, Harmke A. Polinder-Bos, Bob P.A. van de Loo, Hugo van der Kuy, Miriam C. Faes, Jacomien Aleman, Jos Tournoy, Lorenz Van der Linden, Marco Gambera, Isabella Martignoni, Ronald Van Etten, Hein van Onzenoort, Mariette Kappers, Peter van Wijngaarden, Jose Verstijnen, Vera Theeuwes, Marleen Kemper, Elise Slob, Ferdi Sombogaard, Heshu Abdullah-Koolmees, Roland van den Berg, Hugo de Wit, Betul Dilek, Freija Hogenhuis, Vahid Buyukayten, Britt te Brake, Margriet Nieuwenhuijzen, Maria Scheeren, Madelief de Wit, Arjan Bulsink, Ingrid van Haelst, Peter ter Horst, Rosalie Moorlag, Anja Vos, Annemiek Otten-Helmers, Erik van Kan, Marije Voskamp, Marieke Ebbens, Marieke Ezinga, Cees van Nieuwkoop, Loes Visser, Caroline Ghazarian, Doranne Hilarius, Gonneke Hermanides, Carlinda Bresser, Judith Derijks-Engwegen, Ebbie Boemaars, Zahira Getrouw, Barbara Maat, Peter Wierenga, Tessa Bosch, Lisanne Krens, Kajie Liang, Langeza Saleh, Milou van Heuckelum, Linda Hendriksen, Paul van der Linden, Kaylen Guda, Kristel Crommentuijn, Ilse Cornelissen-Wesseling, Jeroen Diepstraten, Jacobien Ellerbroek, Saskia Coenradie, Debbie Deben, Kim Hurkens, Dennis Wong, Marion Vromen, Marjolein de Bock, Suzan Savelkoul, Saskia Wolters, Louise Andrews, Eefje Jong, Rosanne Kranenburg, Joana Soares, Fatima Falcao, Mariana Solano, Erica Viegas, Margarida Falcao, Helena Farinha, Dina Mendes, Joao Rijo, Marta Miarons, Maria Queralt Gorgas, Cristina García Yubero, Laura Portillo Horcajada, Kim Keijzers, Silke Lim, Linden Ashfield, Helen Bell, Naomi Fitzhugh, Glenda Fleming, Nicola Goodfellow, Joanne Hanley, Michael Scott, Simon P. Mooijaart, Jacobijn Gussekloo, Petra Elders, Geeske Peeters

Publikováno v: Heliyon, Vol 10, Iss 23, Pp e40456- (2024)

Background: The clinical frailty scale (CFS) was used as a triage tool for medical decision making during the COVID-19 pandemic. The CFS has been posed as a suitable risk marker for in-hospital mortality in COVID-19 patients. We evaluated whether the

Externí odkaz: https://doaj.org/article/c6e84359db6c419a80d153ef70cdacce