Zobrazeno 1 - 10
of 155
pro vyhledávání: '"ROMAN OSMAN"'
Autor:
Cheuk Wun Li, Roman Osman, Francesca Menconi, Larissa C. Faustino, Kookjoo Kim, Oliver B. Clarke, Hanxi Hou, Yaron Tomer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Autoimmune polyglandular syndrome type 3 variant (APS3v) refers to an autoimmune condition in which both type 1 diabetes (T1D) and autoimmune thyroiditis (AITD) develop in the same individual. HLA-DR3 confers the strongest susceptibility to APS3v. Pr
Externí odkaz:
https://doaj.org/article/1450f3e9884b4371b2b2979151dcc19c
Autor:
Joseph A Newman, Christopher D O Cooper, Anette K Roos, Hazel Aitkenhead, Udo C T Oppermann, Hearn J Cho, Roman Osman, Opher Gileadi
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148762 (2016)
The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 an
Externí odkaz:
https://doaj.org/article/44063d5312b248f0a13c8fa7257d4839
Autor:
Thomas T Joseph, Roman Osman
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 9, p e1002693 (2012)
In RNA interference, a guide strand derived from a short dsRNA such as a microRNA (miRNA) is loaded into Argonaute, the central protein in the RNA Induced Silencing Complex (RISC) that silences messenger RNAs on a sequence-specific basis. The positio
Externí odkaz:
https://doaj.org/article/b96fd8e894d4496aa7cec2e578a7b42e
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e446 (2007)
Calculation of the free energy of protein folding and delineation of its pre-organization are of foremost importance for understanding, predicting and designing biological macromolecules. Here, we introduce an energy smoothing variant of parallel tem
Externí odkaz:
https://doaj.org/article/68ac4d7d0b174aecac8c7563c2813b1e
Autor:
Cheuk Wun Li, Roman Osman, Francesca Menconi, Hanxi Hou, Clyde Schechter, Aizhan Kozhakhmetova, Yaron Tomer
Publikováno v:
Thyroid. 33:492-500
Autor:
Michael J. Capper, Shifan Yang, Alexander C. Stone, Sezen Vatansever, Gregory Zilberg, Yamuna Kalyani Mathiharan, Raul Habib, Keino Hutchinson, Avner Schlessinger, Mihaly Mezei, Roman Osman, Bin Zhang, Daniel Wacker
Anion Exchanger 1 (AE1, SLC4A1) is the primary bicarbonate (HCO3-) transporter expressed in erythrocyte membranes where it mediates transport of CO2between lungs and other tissues via import/export of bicarbonate. It is also a key regulator of erythr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2099c39f01b9568db6c01259a84f2c89
https://doi.org/10.1101/2022.02.11.480130
https://doi.org/10.1101/2022.02.11.480130
Publikováno v:
Proteins
Bromodomains (BrDs), a conserved structural module in chromatin-associated proteins, are well known for recognizing ε-N-acetyl lysine residues on histones. One of the most relevant BrDs is BRD4, a tandem bromodomain containing protein (BrD1 and BrD2
Publikováno v:
J Autoimmun
We have previously identified a signature HLA-DR3 pocket variant, designated HLA-DRβ1-Arg74 that confers a high risk for Graves’ Disease (GD). In view of the key role of HLA-DRβ1-Arg74 in triggering GD we hypothesized that thyroid-stimulating hor
Autor:
Mihaly Mezei, Yaron Tomer, Erlinda Concepcion, Roman Osman, Hanane Arib, Angela Lombardi, Hanxi Hou
Publikováno v:
J Autoimmun
Over the past four decades, the number of people with Type 1 Diabetes (T1D) has increased by 4% per year, making it an important public health challenge. Currently, no curative therapy exists for T1D and the only available treatment is insulin replac
Autor:
Mihaly Mezei, Francesca Menconi, Yaron Tomer, Roman Osman, Eric M. Jacobson, David B. Kastrinsky, Michael Ohlmeyer, Cheuk Wun Li, Erlinda Concepcion, Chella S. David
Publikováno v:
Journal of Biological Chemistry. 291:4079-4090
We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) pepti