Zobrazeno 1 - 10
of 36
pro vyhledávání: '"ROLAND WENGER"'
Publikováno v:
International Journal of Peptide and Protein Research. 31:173-185
The three-dimensional structure of the immunosuppressive cyclic peptide cyclosporine (Cs), determined in crystal by X-ray analysis and in solution in aprotic solvents by n.m.r., differs mainly by the orientation of the 7 carbon side chain of residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153c89a1c42f176f51100afccb59b542
https://doi.org/10.1111/j.1399-3011.1988.tb00020.x
https://doi.org/10.1111/j.1399-3011.1988.tb00020.x
Autor:
Andrew P. Halestrap, Philippe Gallay, Brigitte Rosenwirth, Kamel Besseghir, Marie-Pierre de Béthune, Dirk Jochmans, Roland Wenger, Michael Bobardt, Jean-Maurice Dumont, Luke A. Pallansch, Roger G. Ptak, Erik De Clercq, Urs T. Ruegg, Pietro Scalfaro, Johan Neyts
Publikováno v:
Antimicrobial Agents and Chemotherapy
The introduction of highly active antiretroviral therapy has led to significant changes in disease progression and mortality of human immunodeficiency virus (HIV) type 1 (HIV-1) infection and its sequela, AIDS. HIV-1 infection has been turned into a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44bd4c06094ac984761ecb97f0551c0
https://doi.org/10.1128/aac.01324-07
https://doi.org/10.1128/aac.01324-07
Autor:
HANS FLIRI, GOETZ BAUMANN, ALBERT ENZ, JUERG KALLEN, MARCEL LUYTEN, VINCENT MIKOL, RAO MOVVA, VALERIE QUESNIAUX, MAX SCHREIER, MALCOLM WALKINSHAW, ROLAND WENGER, GERHARD ZENKE, MAURO ZURINI
Publikováno v:
Annals of the New York Academy of Sciences. 696:47-53
Cyclosporin A (Sandimmun) achieves immunosuppressive activity by complex formation with cyclophilin and subsequent binding of the binary complex to and inhibiting protein phosphatase 2B (calcineurin). Complexes of nonimmunosuppressive cyclophilin bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7f4eeba4416946c848ac6bbe945f441
https://doi.org/10.1111/j.1749-6632.1993.tb17141.x
https://doi.org/10.1111/j.1749-6632.1993.tb17141.x
Autor:
Richard Béliveau, Roland Wenger, Arash Sepehr-Araé, Michel Demeule, Alain Laplante, Gérard M. Murphy
Publikováno v:
Kidney International. 57:1590-1598
Association of cyclophilin A with renal brush border membranes: Redistribution by cyclosporine A. Background Administration of the immunosuppressive agent cyclosporine A (CsA) is associated with nephrotoxicity. The main target for CsA, cyclophilin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f6c8de31b95d3fd1d8d164ade27894
https://doi.org/10.1046/j.1523-1755.2000.00003.x
https://doi.org/10.1046/j.1523-1755.2000.00003.x
Autor:
M. C. Cruz, N. R. Movva, Joseph Heitman, Ping Wang, Gerhard Zenke, V. F. J. Quesniaux, M Del Poeta, Roland Wenger, John R. Perfect, Maria E. Cardenas
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:143-149
Cyclosporine (CsA) is an immunosuppressive and antimicrobial drug which, in complex with cyclophilin A, inhibits the protein phosphatase calcineurin. We recently found that Cryptococcus neoformans growth is resistant to CsA at 24°C but sensitive at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa84227c9c903e8277c76416a65144ad
https://doi.org/10.1128/aac.44.1.143-149.2000
https://doi.org/10.1128/aac.44.1.143-149.2000
Autor:
Edith Beaulieu, Roland Wenger, Arash Sepehr-Araé, Diana A. Averill-Bates, Richard Béliveau, Alain Laplante, Michel Demeule
Publikováno v:
Biochemistry and Cell Biology. 77:47-58
The interaction between P-glycoprotein (P-gp) from membranes isolated from multidrug-resistant Chinese hamster ovary cells and cyclosporin A (CsA) analogues and its metabolites was characterized. Screening of these latter as chemosensitizers was perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5736a32815d2a2a0493634c86705e317
https://doi.org/10.1139/o99-011
https://doi.org/10.1139/o99-011
Autor:
Roland Wenger, Soo Y. Ko
Publikováno v:
Helvetica Chimica Acta. 80:695-705
Syntheses of cyclosporine analogues are reported wherein the peptide couplings were achieved in solid phase. The Wang resin was used as the solid support, and the peptide couplings commenced with the residue 11 of the cyclosporine skeleton. The coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49af500de5c55a1a3670d42b844a1afa
https://doi.org/10.1002/hlca.19970800307
https://doi.org/10.1002/hlca.19970800307
Publikováno v:
Journal of Biological Chemistry. 272:6647-6652
The interaction between P-glycoprotein (140-180 kDa) from the multidrug-resistant Chinese hamster ovary cell line CHRC5 and cyclosporin A was characterized using three different photoactivable cyclosporin A analogs. Two monoclonal antibodies, which a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31c108e39813b54146f8c8bdee7d45a
https://doi.org/10.1074/jbc.272.10.6647
https://doi.org/10.1074/jbc.272.10.6647
Autor:
Andreas Billich, P Peichl, G Zenke, Valérie F. J. Quesniaux, F Hammerschmid, Brigitte Rosenwirth, Roland Wenger
Publikováno v:
Journal of Virology. 69:2451-2461
Cyclosporins, in particular the nonimmunosuppressive derivative SDZ NIM 811, exhibit potent anti-human immunodeficiency virus type 1 (HIV-1) activity in vitro. SDZ NIM 811 interferes at two stages of the viral replication cycle: (i) translocation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c767f496a1f05ee266d6a25765d3f
https://doi.org/10.1128/jvi.69.4.2451-2461.1995
https://doi.org/10.1128/jvi.69.4.2451-2461.1995
Autor:
Christian Gerber, Shin-ichiro Shoda, Soo Y. Ko, Dieter Seebach, Manfred Krieger, Adrian Thaler, C. William Murtiashaw, Hans G. Bossler, Reto Naef, Albert K. Beck, Roland Wenger
Publikováno v:
Helvetica Chimica Acta. 76:1564-1590
Strong bases (lithium diisopropylamide (LDA) or BuLi) convert cyclosporin A (CS) to hexalithio derivative containing a Li alkoxide, four Li azaenolate, and one Li enolate units. The Li6 compound is solubilized in tetrahydrofuran (THF) by addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3ff1c7b4e10191d5804ca2d531ac68
https://doi.org/10.1002/hlca.19930760415
https://doi.org/10.1002/hlca.19930760415