Výsledky vyhledávání - "ROBERT N. HUSSON"

Akademický článek

Multi-omic regulatory networks capture downstream effects of kinase inhibition in Mycobacterium tuberculosis

Autor: Albert T. Young, Xavier Carette, Michaela Helmel, Hanno Steen, Robert N. Husson, John Quackenbush, John Platig

Publikováno v: npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-7 (2021)

Abstract The ability of Mycobacterium tuberculosis (Mtb) to adapt to diverse stresses in its host environment is crucial for pathogenesis. Two essential Mtb serine/threonine protein kinases, PknA and PknB, regulate cell growth in response to environm

Externí odkaz: https://doaj.org/article/2df1222b97bb43faa8f378b2567a1374

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

MRSA septic pulmonary emboli presenting as isolated focal chest pain in an adolescent

Autor: Danielle G. Rabinowitz, MD, MM, Stephen M. Chrzanowski, MD, PhD, Jeffrey I. Campbell, MD, Jaclyn Davis, MD, Robert N. Husson, MD, Alicia M. Casey, MD, Carolyn H. Marcus, MD

Publikováno v: Radiology Case Reports, Vol 15, Iss 11, Pp 2406-2409 (2020)

This case demonstrates the importance of considering septic pulmonary embolism (SPE) on the differential for chest pain in the pediatric population, especially in patients with a history of skin and soft tissue infection. The adolescent patient in th

Externí odkaz: https://doaj.org/article/e5b91de239fb4da4aa1a8ceea00306a3

Zobrazit plný text záznamu

Akademický článek

Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome

Autor: Valdir C. Barth, Ju-Mei Zeng, Irina O. Vvedenskaya, Ming Ouyang, Robert N. Husson, Nancy A. Woychik

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

MazF endoribonucleases are thought to arrest growth of Mycobacterium tuberculosis by global translation inhibition. Here, Barth et al. show that MazF-mt9 cleaves a specific tRNA, leading to ribosome stalling at AAA codons and thus selective mRNA degr

Externí odkaz: https://doaj.org/article/f04dbec7370047aab331fe63b011becb

Zobrazit plný text záznamu

Akademický článek

BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny

Autor: Asimenia Angelidou, Joann Diray-Arce, Maria Giulia Conti, Kinga K. Smolen, Simon Daniël van Haren, David J. Dowling, Robert N. Husson, Ofer Levy

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Vaccines have been traditionally developed with the presumption that they exert identical immunogenicity regardless of target population and that they provide protection solely against their target pathogen. However, it is increasingly appreciated th

Externí odkaz: https://doaj.org/article/aaad273a53b14225bf99a23e22d83383

Zobrazit plný text záznamu

Akademický článek

Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface

Publikováno v: mBio, Vol 9, Iss 2 (2018)

ABSTRACT Tuberculosis is the leading killer among infectious diseases worldwide. Increasing multidrug resistance has prompted new approaches for tuberculosis drug development, including targeted inhibition of virulence determinants and of signaling c

Externí odkaz: https://doaj.org/article/499cf436426a467c922809513e71e00a

Zobrazit plný text záznamu

Akademický článek

Correction: A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity.

Autor: Patrick Ymele-Leki, Shugeng Cao, Jared Sharp, Kathleen G. Lambert, Alexander J. McAdam, Robert N. Husson, Giselle Tamayo, Jon Clardy, Paula I. Watnick

Publikováno v: PLoS ONE, Vol 7, Iss 4 (2012)

Externí odkaz: https://doaj.org/article/d768a54845f64fb9b52e7d8e0a4eaa68

Zobrazit plný text záznamu

Childhood Tuberculosis: Historical Perspectives, Recent Advances, and a Call to Action

Autor: Jeffrey I Campbell, Melanie M Dubois, Robert N Husson, Gabriella S Lamb

Publikováno v: Journal of the Pediatric Infectious Diseases Society. 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3162373978f89e8fdd94d1de2893fcb1
https://pubmed.ncbi.nlm.nih.gov/36314551

Zobrazit plný text záznamu

MRSA septic pulmonary emboli presenting as isolated focal chest pain in an adolescent

Autor: Robert N. Husson, Danielle G. Rabinowitz, Stephen M. Chrzanowski, Jeffrey I. Campbell, Carolyn H. Marcus, Alicia Casey, Jaclyn Davis

Publikováno v: Radiology Case Reports
Radiology Case Reports, Vol 15, Iss 11, Pp 2406-2409 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d138b9cb4a7d97503ed8ea00403ff38
http://europepmc.org/articles/PMC7516177

Zobrazit plný text záznamu

Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation

Autor: Asimenia Angelidou, Ofer Levy, Mark Liu, Robert N. Husson, Christine Stabell Benn, Frank Shann, Simon D. van Haren, Mihai G. Netea, Guzman Sanchez-Schmitz, Joann Diray-Arce, Lakshmi-Prasad Potluri, Maria Giulia Conti, Al Ozonoff, Beate Kampmann

Publikováno v: Vaccine
Vaccine, 38, 9, pp. 2229-2240
Angelidou, A, Conti, M G, Diray-Arce, J, Benn, C S, Shann, F, Netea, M G, Liu, M, Potluri, L P, Sanchez-Schmitz, G, Husson, R, Ozonoff, A, Kampmann, B, van Haren, S D & Levy, O 2020, ' Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation ', Vaccine, vol. 38, no. 9, pp. 2229-2240 . https://doi.org/10.1016/j.vaccine.2019.11.060
Vaccine, 38, 2229-2240

Background Bacille Calmette-Guerin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across the globe generating formulations that may differ in clinical efficacy. Innate immune recognition of live BCG contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55026fbb77b1989f8cf274d663d16951
http://europepmc.org/articles/PMC7556328

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání