Zobrazeno 1 - 10
of 453
pro vyhledávání: '"ROBERT K. PRUD'HOMME"'
Autor:
Michael J. Caplan, Richard Baldwin, Xiangyun Yin, Alexander Grishin, Stephanie Eisenbarth, Hugh A. Sampson, Kim Bottomly, Robert K. Prud’homme
Publikováno v:
Communications Materials, Vol 5, Iss 1, Pp 1-11 (2024)
Abstract Immune modulation and desensitization is a growing field of research and clinical investigation that requires precise delivery of antigens to immune system cells. Nanoparticles (NPs) have emerged as excellent candidates for antigen delivery,
Externí odkaz:
https://doaj.org/article/70ea25fc008b413291803f7ea6e74b35
Autor:
Navid Bizmark, Satya Nayagam, Bumjun Kim, David F. Amelemah, Dawei Zhang, Sujit S. Datta, Rodney D. Priestley, Tom Colace, Jane Wang, Robert K. Prud'homme
Publikováno v:
Advanced Materials Interfaces, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract New generations of vaccines have been developed by encapsulating messenger ribonucleic acid (mRNA) in lipid nanoparticle (LNP) carriers. In addition to the physicochemical properties of LNPs, the encapsulation efficiency (EE) of mRNA in LNPs
Externí odkaz:
https://doaj.org/article/4431bf4cea794fbb886d848fcb78ba91
Autor:
Antara Ghosh, Sujan Banik, Kohei Yamada, Shingen Misaka, Robert K. Prud’homme, Hideyuki Sato, Satomi Onoue
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2562 (2023)
In this study, we developed stabilized astaxanthin (AX) nanoparticles (sNP/AX) to improve the physicochemical properties, oral bioavailability, and hepatoprotection of AX. A flash nanoprecipitation technique was used with a multi-inlet vortex mixer t
Externí odkaz:
https://doaj.org/article/a68a3017fff74b568e503ac73f460b06
Autor:
Chester Markwalter, Leon Wang, Ola Sharaf, Prashanth Padakanti, Mark Esposito, Brian Wilson, Eric Blankemeyer, Sean Carlin, Abass Alavi, Robert K. Prud'homme
Publikováno v:
Precision Nanomedicine, Vol 6, Iss 1 (2022)
Nanocarriers encapsulating nucleic acids or protein therapeutics are important tools for modulating biodistribution and enhancing intracellular delivery of biologics. We have recently developed inverse Flash NanoPrecipitation (iFNP), demonstrating it
Externí odkaz:
https://doaj.org/article/590de6680bf241d796ca6122cfa61f91
Autor:
Nafia F. Khan, Malinda Salim, Syaza Y. Binte Abu Bakar, Kurt Ristroph, Robert K. Prud'homme, Adrian Hawley, Ben J. Boyd, Andrew J. Clulow
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100113- (2022)
Lipid-based formulations improve the absorption capacity of poorly-water-soluble drugs and digestion of the formulation is a critical step in that absorption process. A recent approach to understanding the propensity for drug to dissolve in digesting
Externí odkaz:
https://doaj.org/article/b397c6049b6f4ca88b3ffd3395e32c81
Autor:
Tatiana I. Morozova, Victoria E. Lee, Navid Bizmark, Sujit S. Datta, Robert K. Prud’homme, Arash Nikoubashman, Rodney D. Priestley
Publikováno v:
ACS Central Science, Vol 6, Iss 2, Pp 166-173 (2020)
Externí odkaz:
https://doaj.org/article/30a7cbda0f5b4f0195234021dc105408
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-9 (2019)
Abstract Background “Nanomedicine” is the application of purposely designed nano-scale materials for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved using conventional delivery approaches. While “translation”
Externí odkaz:
https://doaj.org/article/a14b0588afc243799b274d6dc23acabd
Autor:
Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White, Robert K. Prud’homme
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly
Externí odkaz:
https://doaj.org/article/ef1329c7cb35484c95cf063ea6909023
Autor:
Simon A. McManus, Yingyue Zhang, Bumjun Kim, Byung Kook Lee, Mohamed E.H. ElSayed, Robert K. Prud'homme
Publikováno v:
Precision Nanomedicine, Vol 3, Iss 4 (2020)
We describe inverse-Flash NanoPrecipitation as a new scalable platform for co-encapsulation of insulin (a model therapeutic peptide) with soybean trypsin inhibitor (a peptidase inhibitor) and so-dium caprate (a permeation enhancer) forming 300 nm par
Externí odkaz:
https://doaj.org/article/c13d4c5be9914f7b85c8205cb9f6ade2
Autor:
Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to impro
Externí odkaz:
https://doaj.org/article/2c4f99fc24ed49b8a965b629b176459d