Zobrazeno 1 - 10
of 369
pro vyhledávání: '"ROBERT J. NASH"'
Autor:
Robert J. Nash, Barbara Bartholomew, Yana B. Penkova, Dino Rotondo, Fernanda Yamasaka, Graham P. Stafford, Sarah F. Jenkinson, George W. J. Fleet
Publikováno v:
ACS Omega, Vol 5, Iss 26, Pp 16263-16271 (2020)
Externí odkaz:
https://doaj.org/article/ba0afb082c944afeaea39aca97574418
Autor:
Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Owolabi W. Banjo, Atsushi Kato, Yana B. Penkova, George W. J. Fleet, Robert J. Nash
Publikováno v:
Molecules, Vol 27, Iss 10, p 3342 (2022)
(1) Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to
Externí odkaz:
https://doaj.org/article/5954b6efd62247e4b8f833b417008b4a
Autor:
David M. Campkin, Yuna Shimadate, Barbara Bartholomew, Paul V. Bernhardt, Robert J. Nash, Jennette A. Sakoff, Atsushi Kato, Michela I. Simone
Publikováno v:
Molecules, Vol 27, Iss 11, p 3447 (2022)
Tetrachlorinated phthalimide analogues bearing a boron-pinacolate ester group were synthesised via two synthetic routes and evaluated in their glycosidase modulating and anticancer properties, with a view to use them in boron neutron capture therapy
Externí odkaz:
https://doaj.org/article/1e9051f89d4a4d5ab3a4f314e45666c7
Autor:
Zahraa S. Al-Taie, Barbara Bartholomew, Christopher Cartmell, Richard T. Froom, Russell G. Kerr, Rolf Kraehenbuehl, Patrick J. Murphy, Robert J. Nash, Yana B. Penkova, Alexander van Teijlingen
Publikováno v:
Molecules, Vol 27, Iss 4, p 1338 (2022)
The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.
Externí odkaz:
https://doaj.org/article/5c6353cb1a5645c69ba03968c9b8daa5
Autor:
Helen L. Whiteland, Anand Chakroborty, Josephine E. Forde-Thomas, Alessandra Crusco, Alan Cookson, Jackie Hollinshead, Caroline A. Fenn, Barbara Bartholomew, Peter A. Holdsworth, Maggie Fisher, Robert J. Nash, Karl F. Hoffmann
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 465-474 (2018)
Two economically and biomedically important platyhelminth species, Fasciola hepatica (liver fluke) and Schistosoma mansoni (blood fluke), are responsible for the neglected tropical diseases (NTDs) fasciolosis and schistosomiasis. Due to the absence o
Externí odkaz:
https://doaj.org/article/d7538bd8d6a54de3a201e4bbc39ca081
Autor:
Hamza Hameed, Elizabeth F. B. King, Katerina Doleckova, Barbara Bartholomew, Jackie Hollinshead, Haddijatou Mbye, Imran Ullah, Karen Walker, Maria Van Veelen, Somaia Saif Abou-Akkada, Robert J. Nash, Paul D. Horrocks, Helen P. Price
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 227 (2021)
The use of plant-derived natural products for the treatment of tropical parasitic diseases often has ethnopharmacological origins. As such, plants grown in temperate regions remain largely untested for novel anti-parasitic activities. We describe her
Externí odkaz:
https://doaj.org/article/4b09ffa503f5486080fe5aeb4bd8ed4b
Autor:
Atsushi Kato, Izumi Nakagome, Mizuki Hata, Robert J. Nash, George W. J. Fleet, Yoshihiro Natori, Yuichi Yoshimura, Isao Adachi, Shuichi Hirono
Publikováno v:
Molecules, Vol 25, Iss 12, p 2843 (2020)
Deoxynojirimycin (DNJ) is the archetypal iminosugar, in which the configuration of the hydroxyl groups in the piperidine ring truly mimic those of d-glucopyranose; DNJ and derivatives have beneficial effects as therapeutic agents, such as anti-diabet
Externí odkaz:
https://doaj.org/article/40f631e564e84a238489d0be7c8c45d9
Autor:
David S. Edgeley, R. Fernando Martínez, Sarah F. Jenkinson, Robert J. Nash, George W. J. Fleet, Amber L. Thompson
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 10, Pp o2865-o2866 (2012)
The absolute stereochemistry of the title compound, C9H15NO7, was determined from the use of d-glucuronolactone as the starting material. The compound crystallizes as the zwitterion. The five-membered ring adopts an envelope conformation with the –
Externí odkaz:
https://doaj.org/article/1ab7e4b04cfa4caa908f490a3f8f09ee
Autor:
Amber L. Thompson, Agnieszka Michalik, Robert J. Nash, Francis X. Wilson, Renate van Well, Peter Johnson, George W. J. Fleet, Chu-Yi Yu, Xiang-Guo Hu, Richard I. Cooper, David J. Watkin
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 11, Pp o2904-o2905 (2009)
X-ray crystallographic analysis of the title hydrobromide salt, C10H20N+·Br−, of (1R,2S,3R,5R,8aR)-3-hydroxymethyl-5-methyloctahydroindolizine-1,2-diol defines the absolute and relative stereochemistry at the five chiral centres in steviamine, a n
Externí odkaz:
https://doaj.org/article/5291fcab05ff425dbeb8474867a68d7c
Autor:
Daniel Best, Sarah F. Jenkinson, Amber L. Thompson, David J. Watkin, Francis X. Wilson, Robert J. Nash, George W. J. Fleet
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 10, Pp o2418-o2419 (2009)
The crystal structure of the title compound, C6H11NO5, establishes the relative configuration at the four stereogenic centres; the absolute configuration is determined by the use of d-glucuronolactone as the starting material for the synthesis. Molec
Externí odkaz:
https://doaj.org/article/66d72599013749ca8cd311cbf23b4982