Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Autor: Alison P. Klein, Brian M. Wolpin, Harvey A. Risch, Rachael Z. Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J. Childs, Jason W. Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A. Arslan, Ana Babic, William R. Bamlet, Laura Beane-Freeman, Sonja I. Berndt, Amanda Blackford, Michael Borges, Ayelet Borgida, Paige M. Bracci, Lauren Brais, Paul Brennan, Hermann Brenner, Bas Bueno-de-Mesquita, Julie Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G. Chaffee, Charles C. Chung, Sean Cleary, Michelle Cotterchio, Frederike Dijk, Eric J. Duell, Lenka Foretova, Charles Fuchs, Niccola Funel, Steven Gallinger, J. Michael M. Gaziano, Maria Gazouli, Graham G. Giles, Edward Giovannucci, Michael Goggins, Gary E. Goodman, Phyllis J. Goodman, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Peter Hegyi, Kathy J. Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A. Holly, Robert Hoover, Rayjean J. Hung, Eric J. Jacobs, Krzysztof Jamroziak, Vladimir Janout, Rudolf Kaaks, Kay-Tee Khaw, Eric A. Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H. Kulke, Juozas Kupcinskas, Robert J. Kurtz, Daniel Laheru, Stefano Landi, Rita T. Lawlor, I.-Min Lee, Loic LeMarchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Mannisto, Roger L. Milne, Beatrice Mohelníková-Duchoňová, Rachel E. Neale, John P. Neoptolemos, Ann L. Oberg, Sara H. Olson, Irene Orlow, Claudio Pasquali, Alpa V. Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Ghislaine Scelo, Howard D. Sesso, Gianluca Severi, Xiao-Ou Shu, Debra Silverman, Jill P. Smith, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Francesca Tavano, Mark D. Thornquist, Geoffrey S. Tobias, Stephen K. Van Den Eeden, Yogesh Vashist, Kala Visvanathan, Pavel Vodicka, Jean Wactawski-Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen Chanock, Ofure Obazee, Gloria M. Petersen, Laufey T. Amundadottir

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci lin

Externí odkaz: https://doaj.org/article/62f48b33d3e24b21a7c8f4e240a960a1

A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer

Autor: William R. Bamlet, Alpa V. Patel, Mingfeng Zhang, Eric J. Jacobs, Tongwu Zhang, Evelina Mocci, Demetrius Albanes, Nilanjan Chatterjee, Alan A. Arslan, Phyllis J. Goodman, Wenming Xiao, Irene Collins, Ghislaine Scelo, Howard D. Sesso, Manolis Kogevinas, Lang Wu, Patricia Hartge, Manal Hasan, Jill P. Smith, Herbert Yu, Laufey T. Amundadottir, Geoffrey S. Tobias, Nathaniel Rothman, Jean Wactawski-Wende, Mengmeng Du, Edward Giovannucci, Stephen K. Van Den Eeden, Roger L. Milne, Irene Orlow, Elizabeth A. Holly, Kathy J. Helzlsouer, Miquel Porta, Ulrike Peters, Harvey A. Risch, Eric J. Duell, Steven Gallinger, Paige M. Bracci, Charles Kooperberg, Michael Goggins, Federico Canzian, Antonia Trichopoulou, Lei Song, Robert J. Kurtz, Brian M. Wolpin, Anne Zeleniuch-Jacquotte, Stephen J. Chanock, Gianluca Severi, Christopher A. Haiman, Loic LeMarchand, Ann L. Oberg, Jason W. Hoskins, Alison P. Klein, Kala Visvanathan, Gary E. Goodman, Gabriella Andreotti, Donghui Li, Charles C. Chung, Michelle Cotterchio, Lauren K. Brais, Satu Männistö, Núria Malats, Jianxin Shi, Charles S. Fuchs, Wei Zheng, Peter Kraft, Robert N. Hoover, J. Michael Gaziano, Erica J. Childs, Nicolas Wentzensen, Kai Yu, Paul Brennan, Mark D. Thornquist, Julie E. Buring, Anne Tjønneland, Jun Zhong, Kevin M. Brown, Ofure Obazee, Rachael Z. Stolzenberg-Solomon, Sabina Sieri, Bas Bueno-de-Mesquita, Debra T. Silverman, Ana Babic, Sonja I. Berndt, Chen Yuan, Ayelet Borgida, Rachel E. Neale, Eric A. Klein, Gloria M. Petersen, Xiao-Ou Shu, Kimmie Ng, Ashley Jermusyk, Graham G. Giles, Laura Beane-Freeman, Emily White, Malin Sund

Publikováno v: Journal of the National Cancer Institute
Journal of the National Cancer Institute, 2020, 112 (10), pp.1003-1012. ⟨10.1093/jnci/djz246⟩

Background Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc20ef24c471c18c4312ce71b7ce709
https://hal.archives-ouvertes.fr/hal-02984282

Comparison of open and laparoscopic treatment of acute appendicitis

Autor: Robert J Kurtz, Tomas M. Heimann

Publikováno v: American journal of surgery. 182(3)

Appendectomy can be performed using either a laparoscopic or an open technique. This study compares the outcome of patients treated for acute appendicitis by open appendectomy with the outcome of those undergoing laparoscopic appendectomy.Patients un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3d7011481d73cd8986d1b670e008b2
https://pubmed.ncbi.nlm.nih.gov/11587679

DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli

Autor: Felice Miller, Thomas M. Fasy, Tomas M. Heimann, Robert J. Kurtz, Giorgio P. Martinelli, Arnold H. Szporn

Publikováno v: Diseases of the colon and rectum. 34(12)

Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more lik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a82f23e2b4d51f594e00f17e87e10b7
https://pubmed.ncbi.nlm.nih.gov/1659978

Analysis of biparietal diameter as an accurate indicator of gestational age

Autor: Ronald J. Wapner, D. David Dershaw, Robert J. Kurtz, Barry B. Goldberg, Alfred B. Kurtz, S D O Carl Rubin, Catherine Cole-Beuglet

Publikováno v: Journal of Clinical Ultrasound. 8:319-326

To date, there have been 25 studies attempting to correlate biparietal diameter and gestational age; of these, 17 meet specific criteria and thus are included in this evaluation. Although all studies have shown an increase in biparietal diameter with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee289c0a97008a2d0dc34b44d37976
https://doi.org/10.1002/jcu.1870080406