Zobrazeno 1 - 10
of 59
pro vyhledávání: '"ROBERT E. HUGHES"'
Autor:
Theodore W. Peters, Christopher S. Nelson, Akos A. Gerencser, Kathleen J. Dumas, Brandon Tavshanjian, Kyu Chul Chang, Gordon J. Lithgow, Robert E. Hughes
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3421-3431 (2018)
A feature common to late onset proteinopathic disorders is an accumulation of toxic protein conformers and aggregates in affected tissues. In the search for potential drug targets, many studies used high-throughput screens to find genes that modify t
Externí odkaz:
https://doaj.org/article/21cf586f07fa4cc2bb6f00f7365e300d
Autor:
Theodore W. Peters, Aaron W. Miller, Cendrine Tourette, Hannah Agren, Alan Hubbard, Robert E. Hughes
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 1, Pp 161-170 (2016)
Adenosine triphosphate (ATP) plays an important role as a primary molecule for the transfer of chemical energy to drive biological processes. ATP also functions as an extracellular signaling molecule in a diverse array of eukaryotic taxa in a conserv
Externí odkaz:
https://doaj.org/article/f685b30bd8b548f7b1e2e13bbccf734d
Publikováno v:
The American Journal of Emergency Medicine. 38:1816-1819
Objective To determine the impact of reported beta-lactam allergies on in-hospital mortality and other clinical outcomes in patients who presented with severe sepsis or septic shock. Methods This single-center, retrospective cohort study was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4f1ca4c58ff4d373b6ce773bd68d84
https://doi.org/10.1016/j.ajem.2020.05.032
https://doi.org/10.1016/j.ajem.2020.05.032
Autor:
Adam L Orr, Deepthi Ashok, Melissa R Sarantos, Ryan Ng, Tong Shi, Akos A Gerencser, Robert E Hughes, Martin D Brand
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89938 (2014)
Mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) is a ubiquinone-linked enzyme in the mitochondrial inner membrane best characterized as part of the glycerol phosphate shuttle that transfers reducing equivalents from cytosolic NADH into th
Externí odkaz:
https://doaj.org/article/8ac684c4cf9941e6b7091d98cd584249
Autor:
Kyu Chul Chang, Akos A. Gerencser, Robert E. Hughes, Kathleen J. Dumas, Brandon Tavshanjian, Gordon J. Lithgow, Theodore W. Peters, Christopher S. Nelson
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3421-3431 (2018)
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3421-3431 (2018)
A feature common to late onset proteinopathic disorders is an accumulation of toxic protein conformers and aggregates in affected tissues. In the search for potential drug targets, many studies used high-throughput screens to find genes that modify t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b248d7bc8c3bbf3f8d8abef225e2b5ec
http://europepmc.org/articles/PMC6222566
http://europepmc.org/articles/PMC6222566
Autor:
Russell Bell, Alan Hubbard, Rakesh Chettier, Di Chen, John P Miller, Pankaj Kapahi, Mark Tarnopolsky, Sudhir Sahasrabuhde, Simon Melov, Robert E Hughes
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000414 (2009)
We have mapped a protein interaction network of human homologs of proteins that modify longevity in invertebrate species. This network is derived from a proteome-scale human protein interaction Core Network generated through unbiased high-throughput
Externí odkaz:
https://doaj.org/article/552fd3a350244799965c9bb6eab896b4
Autor:
Linda S Kaltenbach, Eliana Romero, Robert R Becklin, Rakesh Chettier, Russell Bell, Amit Phansalkar, Andrew Strand, Cameron Torcassi, Justin Savage, Anthony Hurlburt, Guang-Ho Cha, Lubna Ukani, Cindy Lou Chepanoske, Yuejun Zhen, Sudhir Sahasrabudhe, James Olson, Cornelia Kurschner, Lisa M Ellerby, John M Peltier, Juan Botas, Robert E Hughes
Publikováno v:
PLoS Genetics, Vol 3, Iss 5, p e82 (2007)
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involvi
Externí odkaz:
https://doaj.org/article/13bd083a8da44dd192d10530abf31c3c
Autor:
Robert E. Hughes, Cendrine Tourette, Hannah Agren, Alan Hubbard, Aaron W. Miller, Theodore W. Peters
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 1, Pp 161-170 (2016)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Adenosine triphosphate (ATP) plays an important role as a primary molecule for the transfer of chemical energy to drive biological processes. ATP also functions as an extracellular signaling molecule in a diverse array of eukaryotic taxa in a conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50651631d985228336255591bf77d603
http://g3journal.org/lookup/doi/10.1534/g3.115.023267
http://g3journal.org/lookup/doi/10.1534/g3.115.023267
Publikováno v:
The Journal of biological chemistry, vol 289, iss 46
The mammalian target of rapamycin (mTOR) pathway regulates stem cell regeneration and differentiation in response to growth factors, nutrients, cellular energetics, and various extrinsic stressors. Inhibition of mTOR activity has been shown to enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e989eaf38d423d0bf5a301aa6018b1f
https://doi.org/10.1074/jbc.m114.565838
https://doi.org/10.1074/jbc.m114.565838
Autor:
Linda S. Kaltenbach, Russell Bell, Cendrine Tourette, Sean D. Mooney, Shannon O'Hare, Biao Li, Robert E. Hughes
Publikováno v:
Journal of Biological Chemistry. 289:6709-6726
Huntington disease (HD) is an inherited neurodegenerative disease caused by a CAG expansion in the HTT gene. Using yeast two-hybrid methods, we identified a large set of proteins that interact with huntingtin (HTT)-interacting proteins. This network,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37afb173e7edf526885ca1a4093c858d
https://doi.org/10.1074/jbc.m113.523696
https://doi.org/10.1074/jbc.m113.523696