Zobrazeno 1 - 10
of 16
pro vyhledávání: '"ROBERT C. LANMAN"'
Publikováno v:
Biopharmaceutics & Drug Disposition. 19:365-371
Diltiazem and hydrochlorothiazide are widely used to treat cardiovascular disease, often in combination. The purpose of this investigation was to determine whether a drug-drug pharmacokinetic interaction exists between diltiazem and hydrochlorothiazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::590dd487e284f0f3438483ab46547968
https://doi.org/10.1002/(sici)1099-081x(199809)19:6<365::aid-bdd112>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199809)19:6<365::aid-bdd112>3.0.co
Publikováno v:
Pharmaceutical Research. 13:168-172
Purpose. The purpose of this study was to investigate the percutaneous absorption of ketoprofen applied topically to different anatomical sites on the body.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3f3a0b2d6786d8477b8ce2c93fb33b7
https://doi.org/10.1023/a:1016014308638
https://doi.org/10.1023/a:1016014308638
Publikováno v:
Biopharmaceutics & Drug Disposition. 12:515-523
Multiple oral doses of diltiazem (DTZ) and propranolol (PPL, 60 mg every 8 h daily for 13 doses) were administered to 14 healthy volunteers alone and in combination on three separate occasions. Serial blood samples were collected up to 24 h after dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82b14f27b89f5d03952a04b9f60f423
https://doi.org/10.1002/bdd.2510120705
https://doi.org/10.1002/bdd.2510120705
Autor:
Robert C. Lanman, Bruce Morrill, Dennis H. Giesing, Michael B Lanman, Dale K Yu, Larry S Eichmeier, Alfred T Elvin
Publikováno v:
Clinical Pharmacology and Therapeutics. 48:26-33
Single doses of 1 gm 5-aminosalicylic acid (5-ASA) suspension was administered to 24 healthy volunteers during both fasting and fed conditions. For subjects in a fasting state, plasma 5-ASA and acetyl 5-ASA concentrations peaked rapidly 1 hour after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27a7fab66e6254cf318a2af25ccaddb
https://doi.org/10.1038/clpt.1990.113
https://doi.org/10.1038/clpt.1990.113
Autor:
Dennis H. Giesing, M. B. Lanman, Scott J. Weir, L. S. Eichmeier, Robert C. Lanman, B. Morrill, Dale K. Yu
Publikováno v:
European Journal of Clinical Pharmacology.
One gram single dose of Pentasa controlled-release capsules was administered to 24 healthy volunteers under fasting condition. Mean plasma 5-aminosalicylic acid (5-ASA) and acetyl 5-ASA concentrations peaked at 0.53 microgram.ml-1 and 1.33 micrograms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee85d32c1fcbcf85b37a0d4f4959b68b
https://doi.org/10.1007/bf00198311
https://doi.org/10.1007/bf00198311
Publikováno v:
Analytical Letters. 13:381-387
A method is presented for determination of dextrorohan, the O-demethylated metabolite of dextromethorphan, in human Dlasma. Following enzymatic hydrolysis of the glucuronide conjugate, extraction and back extraction prepare the sample for resolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dde0dbbc64b6d2dc480c3ab48ab0539
https://doi.org/10.1080/00032718008059792
https://doi.org/10.1080/00032718008059792
Publikováno v:
Journal of Pharmaceutical Sciences. 75:582-585
Dothiepin hydrochloride (N,N-dimethyldibenzo[b,e]thiepin-delta 11(6 H), gamma-propylamine hydrochloride) is a tricyclic antidepressant which is structurally similar to amitriptyline. Twenty-seven healthy men received three single oral doses of 50-, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412de472fcef4c9b574e3cd1a8f6e243
https://doi.org/10.1002/jps.2600750612
https://doi.org/10.1002/jps.2600750612
Publikováno v:
Journal of Allergy and Clinical Immunology. 66:119-122
A two-way complete crossover bioavailability study of solutions of theophylline given orally or rectally in 16 healthy subjects was conducted. Blood samples were obtained prior to dosing and at 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e7340d9fae2ad8cd0e3036b0cee6be
https://doi.org/10.1016/0091-6749(80)90058-5
https://doi.org/10.1016/0091-6749(80)90058-5
Autor:
Robert C. Lanman, Wen-Han Li
Publikováno v:
Analytical Letters. 20:603-615
A gradient elution HPLC method for analysis of propranolol and three basic metabolites in bile is presented. Before or after hydrolysis with beta-glucuronidase, acetonitrile is added to the bile sample, the resulting mixture is centrifuged at high sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7d1a1db6b44b30bd5da028e34f08e0
https://doi.org/10.1080/00032718708067992
https://doi.org/10.1080/00032718708067992
Publikováno v:
Life Sciences. 10:803-811
Coefficients of free diffusion of some 14 C-labeled saccharides in saline were determined at 37°C by the agar gel method of Schantz and Lauffer. The following values (× 10 −6 cm 2 /sec) were obtained: [1- 14 C]D-mannitol, 9.16; [U- 14 C]D-sucrose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a950898aa42c1c1cc738d3e732e327d4
https://doi.org/10.1016/0024-3205(71)90004-x
https://doi.org/10.1016/0024-3205(71)90004-x