Zobrazeno 1 - 10
of 45
pro vyhledávání: '"ROBERT B. HENDERSON"'
Autor:
Mark E. McClure, Seerapani Gopaluni, James Wason, Robert B. Henderson, Andre Van Maurik, Caroline C.O. Savage, Charles D. Pusey, Alan D. Salama, Paul A. Lyons, Jacinta Lee, Kim Mynard, David R. Jayne, Rachel B. Jones, on behalf the COMBIVAS investigators
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Sequential B cell-targeted immunotherapy with BAFF antagonism (belimumab) and B cell depletion (rituximab) may enhance B cell targeting in ANCA-associated vasculitis (AAV) through several mechanisms. Methods Study design: COMBIVAS
Externí odkaz:
https://doaj.org/article/de0d5603a4e24992b66dd2efe0d957ae
Autor:
Xavier Mariette, Francesca Barone, Chiara Baldini, Hendrika Bootsma, Kenneth L. Clark, Salvatore De Vita, David H. Gardner, Robert B. Henderson, Michael Herdman, Karoline Lerang, Prafull Mistry, Raj Punwaney, Raphaele Seror, John Stone, Paul L.A. van Daele, André van Maurik, Nicolas Wisniacki, David A. Roth, Paul Peter Tak
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
BACKGROUND Primary Sjögren’s syndrome (pSS) is characterized by B cell hyperactivity and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (e.g., belimumab) increases peripheral memory B cells; decreases naive, activated, and plasma B c
Externí odkaz:
https://doaj.org/article/ae87bdd4bc564a1dae2056fee6339f06
Autor:
Christel Wilkinson, Robert B. Henderson, Angela R. Jones-Leone, Shaun M. Flint, Mark Lennon, Roger A. Levy, Beulah Ji, Damon L. Bass, David Roth
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Abstract Background Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post ho
Externí odkaz:
https://doaj.org/article/0924274602404ad3a219d4663a5e0c26
Autor:
Katie L. Connor, Oliver Teenan, Carolynn Cairns, Victoria Banwell, Rachel A.B. Thomas, Julie Rodor, Sarah Finnie, Riinu Pius, Gillian M. Tannahill, Vishal Sahni, Caroline O.S. Savage, Jeremy Hughes, Ewen M. Harrison, Robert B. Henderson, Lorna P. Marson, Bryan R. Conway, Stephen J. Wigmore, Laura Denby
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Small noncoding RNAs, miRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression, or therapeutic efficacy. Bulk tissue small RNA-sequencing (sRNA-Seq)
Externí odkaz:
https://doaj.org/article/0e57397672654b13af1fc22e1d4a45d8
Autor:
Shaun M. Flint, Adele Gibson, Geoff Lucas, Raghava Nandigam, Louise Taylor, Drew Provan, Adrian C. Newland, Caroline O. Savage, Robert B. Henderson
Publikováno v:
Haematologica, Vol 101, Iss 6 (2016)
Primary immune thrombocytopenia is an autoimmune disorder in which platelet destruction is a consequence of both B- and T-cell dysregulation. Flow cytometry was used to further characterize the B- and T-cell compartments in a cross-sectional cohort o
Externí odkaz:
https://doaj.org/article/d1183f911ffd472592f4f5494a930e6c
Autor:
Mark Edward McClure, Seerapani Gopaluni, James Wason, Robert B Henderson, Andre Van Maurik, Caroline Savage, Charles Pusey, Alan Salama, Paul A. Lyons, Jacinta Lee, Kim Mynard, David Jayne, Rachel Jones
Background. Sequential B cell targeted immunotherapy with BAFF antagonism (belimumab) and B cell depletion (rituximab) and may enhance B cell targeting in ANCA-associated vasculitis (AAV) through several mechanisms. Study Design. COMBIVAS is a random
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::597f4ede1020f3f2267354c9ec601d64
https://doi.org/10.21203/rs.3.rs-2138639/v1
https://doi.org/10.21203/rs.3.rs-2138639/v1
Autor:
Robert B. Henderson, Brian Hennessy, Christopher L. Bacon, Patrick Thornton, Richard Flavin, David O'Brien, Fiona Quinn, Hilary O'Leary, Anita Dowling, Michael O'Dwyer, Helen Fogarty, Steve Langabeer, James Nolan, Elisabeth Vandenberghe, Gerard Crotty
Publikováno v:
Irish Journal of Medical Science (1971 -). 190:1087-1094
Introduction Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short di
Autor:
Oliver Teenan, Vishal Sahni, Robert B. Henderson, Bryan R. Conway, Carmel M. Moran, Jeremy Hughes, Laura Denby
Publikováno v:
Teenan, O, Sahni, V, Henderson, R B, Conway, B R, Moran, C M, Hughes, J & Denby, L 2022, ' Sonoporation of human renal proximal tubular epithelial cells in vitro to enhance the liberation of intracellular miRNA biomarkers. ', Ultrasound in Medicine and Biology (UMB) . https://doi.org/10.1016/j.ultrasmedbio.2022.01.019
Ultrasound has previously been demonstrated to non-invasively cause tissue disruption. Small animal studies have demonstrated that this effect can be enhanced by contrast microbubbles and has the potential to be clinically beneficial in techniques su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3002672e1be35f6f764e3f74ebf3d9
https://www.pure.ed.ac.uk/ws/files/251511161/Teenan_et_al_2020_v13_revised_January_2022.docx
https://www.pure.ed.ac.uk/ws/files/251511161/Teenan_et_al_2020_v13_revised_January_2022.docx
Autor:
Julie Rodor, Stephen J. Wigmore, Oliver Teenan, Caroline O. S. Savage, Riinu Pius, Carolynn Cairns, Jeremy Hughes, Bryan R. Conway, Robert B Henderson, Sarah Finnie, Katie Connor, Vishal Sahni, Lorna P. Marson, Gillian M Tannahill, Laura Denby, Ewen M Harrison, Victoria Banwell, Rachel Thomas
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Connor, K L, Teenan, O, Cairns, C, Banwell, V, Thomas, R A B, Rodor, J, Finnie, S, Pius, R, Tannahill, G M, Sahni, V, Savage, C O S, Hughes, J, Harrison, E M, Henderson, R B, Marson, L P, Conway, B R, Wigmore, S J & Denby, L 2020, ' Identifying cell enriched miRNAs in kidney injury and repair ', JCI Insight, vol. 5, no. 24, e140399 . https://doi.org/10.1172/jci.insight.140399
JCI Insight, Vol 5, Iss 24 (2020)
Connor, K L, Teenan, O, Cairns, C, Banwell, V, Thomas, R A B, Rodor, J, Finnie, S, Pius, R, Tannahill, G M, Sahni, V, Savage, C O S, Hughes, J, Harrison, E M, Henderson, R B, Marson, L P, Conway, B R, Wigmore, S J & Denby, L 2020, ' Identifying cell enriched miRNAs in kidney injury and repair ', JCI Insight, vol. 5, no. 24, e140399 . https://doi.org/10.1172/jci.insight.140399
Small noncoding RNA, microRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression or possibly outcome from treatment. Bulk tissue small RNA-Sequencin
Autor:
Shaun M. Flint, Robert B Henderson, Christel Wilkinson, Beulah Ji, Roger A. Levy, Angela Jones-Leone, David M. Roth, Damon Bass, Mark Lennon
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Background Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post hoc meta-an