Zobrazeno 1 - 10
of 356
pro vyhledávání: '"ROBERT A. BLAIR"'
Autor:
Chenxiao Wang, Mst Shamima Khatun, Calder R. Ellsworth, Zheng Chen, Mohammad Islamuddin, Ana Karina Nisperuza Vidal, Mohammad Afaque Alam, Shumei Liu, Janet E. Mccombs, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Xuebin Qin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Toll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated with reduced production of interferons (IFNs). However, the underlying mechanisms remain elusive. To address these questions, we utilize Tlr7 and Irf7 deficienc
Externí odkaz:
https://doaj.org/article/5e54acc9b17c45a78d7bba3cb4b56d54
Autor:
Brandon J. Beddingfield, Kenneth S. Plante, Jessica A. Plante, Scott C. Weaver, Sarah Bose, Clara Krzykwa, Nicole Chirichella, Rachel K. Redmann, Stephanie Z. Seiler, Jason Dufour, Robert V. Blair, Kathrin Endt, Ariane Volkmann, Nicholas J. Maness, Chad J. Roy
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract MVA-based monovalent eastern equine encephalitis virus (MVA-BN-EEEV) and multivalent western, eastern, and Venezuelan equine encephalitis virus (MVA-BN-WEV) vaccines were evaluated in the cynomolgus macaque aerosol model of EEEV infection. M
Externí odkaz:
https://doaj.org/article/91786bd512c949c98f7c1d156f0d183c
Autor:
Chenxiao Wang, Mst Shamima Khatun, Zhe Zhang, Michaela J. Allen, Zheng Chen, Calder R. Ellsworth, Joshua M. Currey, Guixiang Dai, Di Tian, Konrad Bach, Xiao-Ming Yin, Vicki Traina-Dorge, Jay Rappaport, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Derek A. Pociask, Xuebin Qin
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract SARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 mice show patchy pneumonia associated with histiocytic inflammation a
Externí odkaz:
https://doaj.org/article/15de162092a24f62b3a66615cbf80085
Autor:
Alexandra Melton, Lori A. Rowe, Toni Penney, Clara Krzykwa, Kelly Goff, Sarah E. Scheuermann, Hunter J. Melton, Kelsey Williams, Nadia Golden, Kristyn Moore Green, Brandon Smith, Kasi Russell-Lodrigue, Jason P. Dufour, Lara A. Doyle-Meyers, Faith Schiro, Pyone P. Aye, Jeffery D. Lifson, Brandon J. Beddingfield, Robert V. Blair, Rudolf P. Bohm, Jay K. Kolls, Jay Rappaport, James A. Hoxie, Nicholas J. Maness
Publikováno v:
Viruses, Vol 16, Iss 7, p 1173 (2024)
The effects of immunodeficiency associated with chronic HIV infection on COVID-19 disease and viral persistence have not been directly addressed in a controlled setting. In this pilot study, we exposed two pigtail macaques (PTMs) chronically infected
Externí odkaz:
https://doaj.org/article/6540d9832a1c4780aadcbb2a30855213
Autor:
Sydney M. Nemphos, Hannah C. Green, James E. Prusak, Sallie L. Fell, Kelly Goff, Megan Varnado, Kaitlin Didier, Natalie Guy, Matilda J. Moström, Coty Tatum, Chad Massey, Mary B. Barnes, Lori A. Rowe, Carolina Allers, Robert V. Blair, Monica E. Embers, Nicholas J. Maness, Preston A. Marx, Brooke Grasperge, Amitinder Kaur, Kristina De Paris, Jeffrey G. Shaffer, Tiffany Hensley-McBain, Berlin Londono-Renteria, Jennifer A. Manuzak
Publikováno v:
Viruses, Vol 16, Iss 7, p 1036 (2024)
Human immunodeficiency virus (HIV) and malaria, caused by infection with Plasmodium spp., are endemic in similar geographical locations. As a result, there is high potential for HIV/Plasmodium co-infection, which increases the pathology of both disea
Externí odkaz:
https://doaj.org/article/9bcad33d9b354f1fb9c423577b682739
Autor:
Calder R Ellsworth, Chenxiao Wang, Alexis R Katz, Zheng Chen, Mohammad Islamuddin, Haoran Yang, Sarah E Scheuermann, Kelly A Goff, Nicholas J Maness, Robert V Blair, Jay K Kolls, Xuebin Qin
Publikováno v:
Viruses, Vol 16, Iss 4, p 611 (2024)
This study investigates the roles of T, B, and Natural Killer (NK) cells in the pathogenesis of severe COVID-19, utilizing mouse-adapted SARS-CoV-2-MA30 (MA30). To evaluate this MA30 mouse model, we characterized MA30-infected C57BL/6 mice (B6) and c
Externí odkaz:
https://doaj.org/article/18f1be7b00854737818d2aa9e4dc0ac8
Autor:
Matilda J Moström, Shan Yu, Dollnovan Tran, Frances M Saccoccio, Cyril J Versoza, Daniel Malouli, Anne Mirza, Sarah Valencia, Margaret Gilbert, Robert V Blair, Scott Hansen, Peter Barry, Klaus Früh, Jeffrey D Jensen, Susanne P Pfeifer, Timothy F Kowalik, Sallie R Permar, Amitinder Kaur
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011646 (2023)
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neurologic defects in newborns with particularly severe sequelae in the setting of primary CMV infection in the first trimester of pregnancy. The majority of cCMV cases worldwide oc
Externí odkaz:
https://doaj.org/article/1f4052f269cf4439b401b378a9c37424
Autor:
Alyssa C. Fears, Edith M. Walker, Nicole Chirichella, Nadia Slisarenko, Kristen M. Merino, Nadia Golden, Breanna Picou, Skye Spencer, Kasi E. Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, Brandon J. Beddingfield, Nicholas J. Maness, Chad J. Roy, Namita Rout
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The dynamics of γδ T cell frequencies and functions through the course of SARS-CoV-2 infection in rhesus macaques and African green monkeys reveals that Vδ1 γδ T cells are involved in the early immune response to SARS-CoV-2 infection.
Externí odkaz:
https://doaj.org/article/18520bbe745343c7bc6104e42afbb428
Autor:
Ibolya Rutkai, Meredith G. Mayer, Linh M. Hellmers, Bo Ning, Zhen Huang, Christopher J. Monjure, Carol Coyne, Rachel Silvestri, Nadia Golden, Krystle Hensley, Kristin Chandler, Gabrielle Lehmicke, Gregory J. Bix, Nicholas J. Maness, Kasi Russell-Lodrigue, Tony Y. Hu, Chad J. Roy, Robert V. Blair, Rudolf Bohm, Lara A. Doyle-Meyers, Jay Rappaport, Tracy Fischer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
COVID-19 can result in neurological manifestations and animal models could provide insights into the mechanisms. Here, the authors describe neuroinflammation, microhemorrhages and brain hypoxia in SARS-CoV-2 infected non-human primates, including in
Externí odkaz:
https://doaj.org/article/0c1be27d8686492ebe212a4588149d65
Autor:
Brandon J. Beddingfield, Nicholas J. Maness, Skye Spencer, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, HongMei Gao, David Montefiori, Chad J. Roy
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSARS-CoV-2 is a respiratory pathogen currently causing a worldwide pandemic, with resulting pathology of differing severity in humans, from mild illness to severe disease and death. The rhesus macaque model of COVID-19 was utilized to eva
Externí odkaz:
https://doaj.org/article/3772dde98cab499297a36830dbf4d85e