Výsledky vyhledávání - "RNP biogenesis"

Akademický článek

Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network

Autor: A. Gregory Matera, Rebecca E. Steiner, C. Allie Mills, Benjamin D. McMichael, Laura E. Herring, Eric L. Garcia

Publikováno v: Frontiers in RNA Research, Vol 2 (2024)

IntroductionMolecular chaperones and co-chaperones are highly conserved cellular components that perform a variety of duties related to the proper three-dimensional folding of the proteome. The web of factors that carries out this essential task is c

Externí odkaz: https://doaj.org/article/9428fafe243740aeb08226fc03eb62c2

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NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis

Autor: Franck Vandermoere, Tiago M. Bandeiras, Ana C. F. Paiva, Edouard Bertrand, Bruno Charpentier, Xavier Manival, Céline Verheggen, Marie-Eve Chagot, Pedro M. F. Sousa, Marc Quinternet, Marie-Cécile Robert, Philippe Fort, Paulo E. Santo, Jonathan Bizarro, Yoann Abel

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, In press, 49 (2), pp.1094-1113. ⟨10.1093/nar/gkaa1226⟩
Nucleic Acids Research, 2021, 49 (2), pp.1094-1113. ⟨10.1093/nar/gkaa1226⟩

The PAQosome is a large complex composed of the HSP90/R2TP chaperone and a prefoldin-like module. It promotes the biogenesis of cellular machineries but it is unclear how it discriminates closely related client proteins. Among the main PAQosome clien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3353ae141945db90b5fe30d422a6fb
https://doi.org/10.1093/nar/gkaa1226

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Inherited SHQ1 mutations impair interaction with NAP57/dyskerin, a major target in dyskeratosis congenita

Autor: Jonathan Bizarro, U. Thomas Meier

Publikováno v: Molecular Genetics & Genomic Medicine

Background The inherited bone marrow failure syndrome dyskeratosis congenita (DC) is most frequently caused by mutations in DKC1 (MIM# 300126), the gene encoding NAP57 (aka dyskerin). The typically missense mutations modulate the interaction of NAP57

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68123eef71fc2a94d6ddd95eed987e0b
https://doi.org/10.1002/mgg3.314

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Human intron-encoded AluACA RNAs and telomerase RNA share a common element promoting RNA accumulation

Autor: Amandine Ketele, Beáta E. Jády, Tamás Kiss

Publikováno v: RNA Biology

Mammalian cells express hundreds of intron-encoded box H/ACA RNAs which fold into a common hairpin-hinge-hairpin-tail structure, interact with 4 evolutionarily conserved proteins, dyskerin, Nop10, Nhp2 and Gar1, and function mainly in RNA pseudouridy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e69fad3832cad4f6dba69b0a434425
http://europepmc.org/articles/PMC5207380

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Exportin T and Exportin 5: tRNA and miRNA biogenesis – and beyond

Autor: Matthias S. Leisegang, Markus T. Bohnsack, Ana S. Ramírez, Roman Martin

Publikováno v: bchm. 393:599-604

The biogenesis of most eukaryotic kinds of RNA requires nuclear export, which is mediated by a variety of specific nuclear transport receptors. The nuclear export receptors Exportin-t (Exp-t) and Exportin 5 (Exp5), and their homologues, are involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfcffc712d4dbc2779960ae8b7d5a38
https://doi.org/10.1515/hsz-2012-0146

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Dissertation/ Thesis

Étude des interactions protéine-protéine entre le complexe de Survie des MotoNeurones (SMN) et les facteurs d'assemblage des RNP à boîtes C/D et H/ACA

Autor: Huttin, Alexandra

Les particules ribonucléoprotéiques (RNP) à boîtes C/D et H/ACA sont impliquées dans la maturation des UsnRNA et des précurseurs des ARNr. L'assemblage de ces RNP dans les cellules est un processus complexe faisant intervenir de nombreux facteu

Externí odkaz: http://www.theses.fr/2012LORR0250

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Study of the protein-protein interactions between the SMN complex and the factors required for box C/D and H/ACA RNP assembly

Autor: Huttin, Alexandra

Publikováno v: Biochimie, Biologie Moléculaire. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0250⟩

Box C/D and H/ACA ribonucleoparticles (RNPs) are required for UsnRNA and ribosomal RNA maturation. Their assembly in cells is a complex process, which implicates numerous cellular factors, such as NUFIP, a common assembly factor, and NAF1, which is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::40504f6c749a2ca0a078d1b60ad936e6
https://hal.univ-lorraine.fr/tel-01749635

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