Zobrazeno 1 - 10
of 1 032
pro vyhledávání: '"RNAI SCREEN"'
Autor:
Viviana Vella, Angeliki Ditsiou, Anna Chalari, Murat Eravci, Sarah K. Wooller, Teresa Gagliano, Cecilia Bani, Emanuela Kerschbamer, Christos Karakostas, Bin Xu, Yongchang Zhang, Frances M.G. Pearl, Gianluca Lopez, Ling Peng, Justin Stebbing, Apostolos Klinakis, Georgios Giamas
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Temozolomide (TMZ) represents the cornerstone of therapy for glioblastoma (GBM). However, acquisition of resistance limits its therapeutic potential. The human kinome is an undisputable source of druggable targets, still, current knowledge r
Externí odkaz:
https://doaj.org/article/10bdea1081e24054b2aa80185b300ab8
Autor:
Muhammad Salim Hakeemi, Salim Ansari, Matthias Teuscher, Matthias Weißkopf, Daniela Großmann, Tobias Kessel, Jürgen Dönitz, Janna Siemanowski, Xuebin Wan, Dorothea Schultheis, Manfred Frasch, Siegfried Roth, Michael Schoppmeier, Martin Klingler, Gregor Bucher
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Most of the known genes required for developmental processes have been identified by genetic screens in a few well-studied model organisms, which have been considered representative of related species, and informative—to some de
Externí odkaz:
https://doaj.org/article/f958f28f3e5f489d8ea8a8d99b722eb3
Autor:
Kuoyuan Cheng, Laura Martin‐Sancho, Lipika R Pal, Yuan Pu, Laura Riva, Xin Yin, Sanju Sinha, Nishanth Ulhas Nair, Sumit K Chanda, Eytan Ruppin
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 11, Pp 1-19 (2021)
Abstract Tremendous progress has been made to control the COVID‐19 pandemic caused by the SARS‐CoV‐2 virus. However, effective therapeutic options are still rare. Drug repurposing and combination represent practical strategies to address this u
Externí odkaz:
https://doaj.org/article/7f7daa898bfc42e18657f5c1309d7466
Autor:
Yingxue Li, Wei Xu, Yutian Ren, Hung-Chi Cheung, Panpan Huang, Guneet Kaur, Chih-Jung Kuo, Sean P. McDonough, Susan L. Fubini, Stephen M. Lipkin, Xin Deng, Yung-Fu Chang, Linfeng Huang
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated intestinal disease, resulting in severe diarrhea and fatal pseudomembranous colitis. TcdB, one of the essential virulence factors secreted by this bacteri
Externí odkaz:
https://doaj.org/article/f893863f5bbe4b2a82abc1479b583357
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract The establishment of the functional nervous system requires coordinated development of neurons and glia in the embryo. Our understanding of underlying molecular and cellular mechanisms, however, remains limited. The developing Drosophila vis
Externí odkaz:
https://doaj.org/article/a25728f4f6cb4ab7a333b03954769d4d
Akademický článek
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Akademický článek
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Autor:
Azadeh Laffafian, Ulrich Tepass
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 12, Pp 4007-4017 (2019)
Externí odkaz:
https://doaj.org/article/e038d58e7434422cadbdee57884e9bf4
Autor:
Abir Arfaoui, Claire Rioualen, Violette Azzoni, Guillaume Pinna, Pascal Finetti, Julien Wicinski, Emmanuelle Josselin, Manon Macario, Rémy Castellano, Candi Léonard‐Stumpf, Anthony Bal, Abigaelle Gros, Sylvain Lossy, Maher Kharrat, Yves Collette, Francois Bertucci, Daniel Birnbaum, Hayet Douik, Ghislain Bidaut, Emmanuelle Charafe‐Jauffret, Christophe Ginestier
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-18 (2019)
Abstract Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic tar
Externí odkaz:
https://doaj.org/article/c9002abaa4bb472dafea9936d6b75e8c
Autor:
Zain Umer, Jawad Akhtar, Muhammad Haider Farooq Khan, Najma Shaheen, Muhammad Abdul Haseeb, Khalida Mazhar, Aziz Mithani, Saima Anwar, Muhammad Tariq
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-15 (2019)
Abstract Background Polycomb group (PcG) and trithorax group (trxG) proteins contribute to the specialization of cell types by maintaining differential gene expression patterns. Initially discovered as positive regulators of HOX genes in forward gene
Externí odkaz:
https://doaj.org/article/e08b229a9b514271b7a9562becd3a419