Výsledky vyhledávání - "RNA-binding proteins (RBP)"

Akademický článek

GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins

Autor: Wandi S. Zhu, Adam J. Litterman, Harshaan S. Sekhon, Robin Kageyama, Maya M. Arce, Kimberly E. Taylor, Wenxue Zhao, Lindsey A. Criswell, Noah Zaitlen, David J. Erle, K. Mark Ansel

Publikováno v: Genome Biology, Vol 24, Iss 1, Pp 1-30 (2023)

Abstract GCLiPP is a global RNA interactome capture method that detects RNA-binding protein (RBP) occupancy transcriptome-wide. GCLiPP maps RBP-occupied sites at a higher resolution than phase separation-based techniques. GCLiPP sequence tags corresp

Externí odkaz: https://doaj.org/article/d9d0f867d61c4eb2b44c5c8f804f28be

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Akademický článek

Stress Granules in the Post-transcriptional Regulation of Immune Cells

Autor: Nicolas Curdy, Olivia Lanvin, Sarah Cadot, Camille Laurent, Jean-Jacques Fournié, Don-Marc Franchini

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2021)

Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response. These dynamic processes require an intricate orchestration

Externí odkaz: https://doaj.org/article/6eed090c3d4943ee9d0f3e5e29acd06a

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Akademický článek

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Akademický článek

Characterization of the mRNA untranslated regions [UTR] of the Trypanosoma cruzi LYT1 isoforms derived by alternative trans-splicing

Autor: César Augusto Ramírez, Julián Camilo Casas, María Isabel Ospina, José María Requena, Concepción J. Puerta

Publikováno v: Universitas Scientiarum, Vol 23, Iss 2, Pp 267-290 (2018)

In trypanosomatids, gene expression is mainly regulated at posttranscriptional level, through mechanisms based on the interaction between RNA Binding Proteins [RBPs] and motifs present in the untranslated regions [UTRs] of them RNAs, which altogether

Externí odkaz: https://doaj.org/article/e6d6af8dd14d483abb6939d774822164

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Akademický článek

Transcriptomic Analysis Identifies RNA Binding Proteins as Putative Regulators of Myelopoiesis and Leukemia

Autor: Subha Saha, Krushna Chandra Murmu, Mayukh Biswas, Sohini Chakraborty, Jhinuk Basu, Swati Madhulika, Srinivasa Prasad Kolapalli, Santosh Chauhan, Amitava Sengupta, Punit Prasad

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Acute myeloid leukemia (AML) is a common and aggressive hematological malignancy. Acquisition of heterogeneous genetic aberrations and epigenetic dysregulation lead to the transformation of hematopoietic stem cells (HSC) into leukemic stem cells (LSC

Externí odkaz: https://doaj.org/article/30803bc55e61450d97dcef14d86a8355

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Stress Granules in the Post-transcriptional Regulation of Immune Cells

Autor: Curdy, Nicolas, Lanvin, Olivia, Cadot, Sarah, Laurent, Camille, Fournié, Jean-Jacques, Franchini, Don-Marc

Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, 2021, 8, ⟨10.3389/fcell.2020.611185⟩
Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 8, ⟨10.3389/fcell.2020.611185⟩

International audience; Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response. These dynamic processes require an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dbb0d1e55f0bc38f07b57db31b4880a6
https://hal.science/hal-03365427

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Linking Huntington's Disease and X-linked Dystonia Parkinsonism on the Molecular Level

Autor: Katja Lohmann, Sokhna Haissatou Diaw

Publikováno v: Brain

A TAF1 mutation that lowers levels of the transcript causes X-linked dystonia parkinsonism. Hernández et al. show reduced levels of TAF1, and of the RNA-binding protein SREK1 which targets TAF1, also in Huntington’s disease. SREK1 overexpression r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8646c2fa9b037e13eee2b9ca7af97193
https://pubmed.ncbi.nlm.nih.gov/32533168

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Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism

Autor: Manuel Sánchez-Martín, Belén Pintado, José J. Lucas, Maria Jose Perez-Alvarez, Ramón García-Escudero, Verónica Domínguez, Ivó H. Hernández, María Santos-Galindo, Jorge Rubén Cabrera

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The Author(s) (2020).
Huntington’s disease and X-linked dystonia parkinsonism are two monogenic basal ganglia model diseases. Huntington’s disease is caused by a polyglutamine-encoding CAG repeat expansion in the Huntingtin (HTT) gene leadin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c9d15d5e10c30c8d231053363eaed7
http://hdl.handle.net/10261/229569

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Characterization of the mRNA untranslated regions [UTR] of the Trypanosoma cruzi LYT1 isoforms derived by alternative trans-splicing

Autor: Julián Camilo Casas, Elizabeth Ruiz, Concepción J. Puerta, César A. Ramírez, María Isabel Ospina, Jose M. Requena

Publikováno v: Universitas Scientiarum, Vol 23, Iss 2, Pp 267-290 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname

In trypanosomatids,geneexpressionismainlyregulated at posttranscriptional level,throughmechanisms based on the interaction between RNA Binding Proteins [RBPs] and motifs present in the untranslated regions [UTRs] of Them RNAs,whichaltogetherformribon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc186acf65dcd99ea375e823690f8f58
https://doi.org/10.11144/javeriana.sc23-2.cotm

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