Zobrazeno 1 - 10
of 5 842
pro vyhledávání: '"RNA structure"'
Publikováno v:
Human-Centric Intelligent Systems, Vol 4, Iss 2, Pp 220-240 (2024)
Abstract Ribonucleic acid (RNA) structure is vital to its ability to function within the cell. The ability to predict RNA structure is essential to implementing new medications and understanding genetic illnesses. It is also important in synthetic an
Externí odkaz:
https://doaj.org/article/803a723e8e784712a5fed78d3f508ad4
Autor:
Weiting Zhang, Karl Petri, Junyan Ma, Hyunho Lee, Chia-Lun Tsai, J Keith Joung, Jing-Ruey Joanna Yeh
Publikováno v:
eLife, Vol 12 (2024)
CRISPR prime editing (PE) requires a Cas9 nickase-reverse transcriptase fusion protein (known as PE2) and a prime editing guide RNA (pegRNA), an extended version of a standard guide RNA (gRNA) that both specifies the intended target genomic sequence
Externí odkaz:
https://doaj.org/article/ad99b0e410504a6dbdf94fc1701017e7
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract The development of in vitro transcribed mRNA (IVT mRNA)‐based therapeutics/vaccines depends on the management of IVT mRNA immunogenicity. IVT mRNA, which is used for intracellular protein translation, often triggers unwanted immune respons
Externí odkaz:
https://doaj.org/article/cab12ece8b704416b7ad6ea580f7fcd0
Autor:
Jie Deng, Xianyang Fang, Lin Huang, Shanshan Li, Lilei Xu, Keqiong Ye, Jinsong Zhang, Kaiming Zhang, Qiangfeng Cliff Zhang
Publikováno v:
Fundamental Research, Vol 3, Iss 5, Pp 727-737 (2023)
RNA molecules serve a wide range of functions that are closely linked to their structures. The basic structural units of RNA consist of single- and double-stranded regions. In order to carry out advanced functions such as catalysis and ligand binding
Externí odkaz:
https://doaj.org/article/4828766ef7204c199ec89812e92426df
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 666-680 (2023)
CRISPR technologies comprising a Cas nuclease and a guide RNA (gRNA) can utilize multiple gRNAs to enact multi-site editing or regulation in the same cell. Nature devised a highly compact means of encoding gRNAs in the form of CRISPR arrays composed
Externí odkaz:
https://doaj.org/article/fde7e1846cdc41ca814ee8c762767e35
Autor:
Jason R. Stagno, Yun-Xing Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10682 (2024)
Riboswitches are highly structured RNA regulators of gene expression. Although found in all three domains of life, they are particularly abundant and widespread in bacteria, including many human pathogens, thus making them an attractive target for an
Externí odkaz:
https://doaj.org/article/b3631c53ae94449a8aff9d19f60a8e4e
Autor:
Paul Rosenfeld, Gatikrushna Singh, Amanda Paz Herrera, Juan Ji, Bradley Seufzer, Xiao Heng, Kathleen Boris-Lawrie, Alan Cochrane
Publikováno v:
Viruses, Vol 16, Iss 9, p 1506 (2024)
Our examination of RNA helicases for effects on HIV-1 protein production and particle assembly identified Rocaglamide (RocA), a known modulator of eIF4A1 function, as an inhibitor of HIV-1 replication in primary CD4+ T cells and three cell systems. H
Externí odkaz:
https://doaj.org/article/c1097bdb587d4cc7a05a32e1f45331f9
Autor:
Boyang Shi, Ke An, Yueqin Wang, Yuhan Fei, Caixia Guo, Qiangfeng Cliff Zhang, Yun-Gui Yang, Xin Tian, Quancheng Kan
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 4, Pp 850-865 (2023)
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) positively affect the initial control of non-small cell lung cancer (NSCLC). Rapidly acquired resistance to EGFR-TKIs is a major hurdle in successful treatment. However, the mech
Externí odkaz:
https://doaj.org/article/c6e59523a7464d8bbc054b8c9402d7d1
Autor:
Stephanie E. Ander, Kathryn S. Carpentier, Wes Sanders, Cormac J. Lucas, Austin J. Jolly, Cydney N. Johnson, David W. Hawman, Mark T. Heise, Nathaniel J. Moorman, Thomas E. Morrison
Publikováno v:
Viruses, Vol 16, Iss 6, p 861 (2024)
We previously reported that deletion of a 44-nucleotide element in the 3′ untranslated region (UTR) of the Chikungunya virus (CHIKV) genome enhances the virulence of CHIKV infection in mice. Here, we find that while this 44-nucleotide deletion enha
Externí odkaz:
https://doaj.org/article/de9d1c236b594b4e9eb72f3e4301308c
Autor:
Giovanni Blandino, Roberto Dinami, Marco Marcia, Eleni Anastasiadou, Brid M. Ryan, Alina Catalina Palcau, Luigi Fattore, Giulia Regazzo, Rosanna Sestito, Rossella Loria, Ana Belén Díaz Méndez, Maria Chiara Cappelletto, Claudio Pulito, Laura Monteonofrio, George A. Calin, Gabriella Sozzi, Jit Kong Cheong, Ranit Aharonov, Gennaro Ciliberto
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeutics” highlightes the signi
Externí odkaz:
https://doaj.org/article/3a1f4e3c811547579a213904c93a8094