Zobrazeno 1 - 10
of 4 025
pro vyhledávání: '"RNA secondary structure"'
Subgenomic flaviviral RNAs and human proteins: in silico exploration of anti-host defense mechanisms
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3527-3536 (2024)
Flaviviruses pose significant global health threats, infecting over 300 million people annually. Among their evasion strategies, the production of subgenomic flaviviral RNAs (sfRNAs) from the 3′ UTR of viral genomes is particularly notable. Utilizi
Externí odkaz:
https://doaj.org/article/9c439f4cfa5a4027b04305231bf9c89e
Autor:
Sandra Triebel, Kevin Lamkiewicz, Nancy Ontiveros, Blake Sweeney, Peter F. Stadler, Anton I. Petrov, Michael Niepmann, Manja Marz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Hepatitis C virus (HCV) is a plus-stranded RNA virus that often chronically infects liver hepatocytes and causes liver cirrhosis and cancer. These viruses replicate their genomes employing error-prone replicases. Thereby, they routinely gene
Externí odkaz:
https://doaj.org/article/60cac77d8c7c49d1b81ee5d4959f6b3e
Publikováno v:
F1000Research, Vol 10 (2024)
Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had led to a global pandemic since December 2019. SARS-CoV-2 is a single-stranded RNA virus, which mutates at a higher rate. Multiple works had been done to stud
Externí odkaz:
https://doaj.org/article/a8b7f194f9c541ecb05cff58c0ad2a26
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Uncovering functional genetic variants from an allele-specific perspective is of paramount importance in advancing our understanding of gene regulation and genetic diseases. Recently, various allele-specific events, such as allele
Externí odkaz:
https://doaj.org/article/d105233902ed4ddbaea29c914bce1154
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 481-505 (2024)
Abstract Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expr
Externí odkaz:
https://doaj.org/article/e3f9a0a3fd414444937ad4be2d5c08c9
Autor:
Tianru Zhang, Changhao Li, Jiaying Zhu, Yanjun Li, Zhiye Wang, Chun-Yip Tong, Yu Xi, Yi Han, Hisashi Koiwa, Xu Peng, Xiuren Zhang
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-31 (2024)
Abstract Background RNA secondary structure (RSS) can influence the regulation of transcription, RNA processing, and protein synthesis, among other processes. 3′ untranslated regions (3′ UTRs) of mRNA also hold the key for many aspects of gene re
Externí odkaz:
https://doaj.org/article/cce8238e71cf407d8e1a085baa61602d
Autor:
Konstantinos Karakostis, Laurence Malbert-Colas, Aikaterini Thermou, Borek Vojtesek, Robin Fåhraeus
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background The ATM kinase constitutes a master regulatory hub of DNA damage and activates the p53 response pathway by phosphorylating the MDM2 protein, which develops an affinity for the p53 mRNA secondary structure. Disruption of this inter
Externí odkaz:
https://doaj.org/article/6c35679e66534f3596b761aa7d227558
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
N6-methyladenosine (m6A) methylation is an internal post-transcriptional modification that has been linked to viral multiplication and pathogenicity. To elucidate the conservation patterns of potential 5′-DRACH-3′ motifs in avian leukosis virus s
Externí odkaz:
https://doaj.org/article/b3a3e13607a24a1c9bfe42bdd24d630d
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 11, Pp 19320-19340 (2023)
The RNA secondary structure is like a blueprint that holds the key to unlocking the mysteries of RNA function and 3D structure. It serves as a crucial foundation for investigating the complex world of RNA, making it an indispensable component of rese
Externí odkaz:
https://doaj.org/article/89ecf8dd2ef24cfe80285e2db5143956
Autor:
Laura I. Levi, Emily A. Madden, Jeremy Boussier, Diana Erazo, Wes Sanders, Thomas Vallet, Veronika Bernhauerova, Nathaniel J. Moorman, Mark T. Heise, Marco Vignuzzi
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1794 (2024)
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that poses an emerging threat to humans. In a manner similar to other RNA viruses, CHIKV encodes an error-prone RNA polymerase which, in addition to producing full-length genomes, gives rise to
Externí odkaz:
https://doaj.org/article/00b34d58734a413eb02922eff3e1bfa2