Zobrazeno 1 - 10
of 833
pro vyhledávání: '"RNA delivery"'
Autor:
I. P. Shilovskiy, G. B. Pasikhov, V. V. Smirnov, I. A. Kofiadi, M. V. Popova, P. A. Strueva, M. R. Khaitov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 157-171 (2024)
INTRODUCTION. Small interfering RNAs (siRNAs) are among the most promising types of therapeutic nucleic acids aiming at the inhibition of pathogenetically relevant gene expression through the RNA interference mechanism. However, the limited bioavaila
Externí odkaz:
https://doaj.org/article/eb2d2fbfb84c4e88a2f8d5a7cea9133d
Autor:
Shunye Su, Leyi Liu, Qingfeng Fu, Minghao Ma, Na Yang, Ting Pan, Shengyong Geng, Xue-Feng Yu, Jianqiang Zhu
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Prostate cancer (PCa) has a high incidence in men worldwide, and almost all PCa patients progress to the androgen-independent stage which lacks effective treatment measures. PTENP1, a long non-coding RNA, has been shown to suppres
Externí odkaz:
https://doaj.org/article/18d9cb3358e8420ea394634fea83c3e8
Autor:
Li Wang, Qunyan Yao, Xuerui Guo, Bingmei Wang, Jingyi Si, Xingye Wang, Shisong Jing, Ming Yan, Yan Shi, Guangqi Song, Xizhong Shen, Jiyu Guan, Yicheng Zhao, Changfeng Zhu
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), remains a highly lethal malignancy with limited therapeutic options and a dismal prognosis. By targeting the underlying molecular abnormalities responsible for PDAC de
Externí odkaz:
https://doaj.org/article/29823b50b96a453db79b7b3416bb8c4e
Publikováno v:
Medical Review, Vol 4, Iss 3, Pp 207-224 (2024)
RNA-based therapeutics have emerged as a promising approach for the treatment of various diseases, including cancer, genetic disorders, and infectious diseases. However, the delivery of RNA molecules into target cells has been a major challenge due t
Externí odkaz:
https://doaj.org/article/ac6b819166ca4163809acf1d149d6a95
Autor:
Suzanne Saffie-Siebert, Nissim Torabi-Pour, Andrew Gibson, Flavia Maria Sutera, Ashkan Dehsorkhi, Paulina Baran-Rachwalska, Skye Quinn
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101299- (2024)
While lipid nanoparticles (LNPs) are a key enabling technology for RNA-based therapeutics, some outstanding challenges hinder their wider clinical translation and use, particularly in terms of RNA stability and limited shelf life. In response to thes
Externí odkaz:
https://doaj.org/article/84c1eb6a1a7b46718fb4c4533d562614
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Transmembrane delivery of biologically active nucleic acids is an important process in cells and has inspired one to develop advanced drug delivery techniques. In this contribution, molecular‐level single‐stranded nucleic acid transmembr
Externí odkaz:
https://doaj.org/article/9b5b7f2a923049b19c20429f5117c7d1
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 579-601 (2024)
Lipid nanovehicles are currently the most advanced vehicles used for RNA delivery, as demonstrated by the approval of patisiran for amyloidosis therapy in 2018. To illuminate the unique superiority of lipid nanovehicles in RNA delivery, in this revie
Externí odkaz:
https://doaj.org/article/a4c0f61fa9fd470a8757b41e70ac2229
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116691- (2024)
Neurodegenerative diseases affect many people worldwide, and as the population ages, the incidence of these conditions increases. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most prevalent neurodegenerative disorders worldwide.
Externí odkaz:
https://doaj.org/article/891f2fbde8b74beb9fa46d46be39ffab
Publikováno v:
Pathogens, Vol 13, Iss 8, p 692 (2024)
Engineered circular RNAs (circRNAs) are a class of single-stranded RNAs with head-to-tail covalently linked structures that integrate open reading frames (ORFs) and internal ribosome entry sites (IRESs) with the function of coding and expressing prot
Externí odkaz:
https://doaj.org/article/98150d8ec2ae455e986ed2b7df21e26d
Autor:
Wuxia Zhang, Yupeng Chen
Publikováno v:
Frontiers in Chemistry, Vol 11 (2024)
Janus base nanotubes are novel, self-assembled nanomaterials. Their original designs were inspired by DNA base pairs, and today a variety of chemistries has developed, distinguishing them as a new family of materials separate from DNA origami, carbon
Externí odkaz:
https://doaj.org/article/fea35c561e19433b8cab37d80ae512fa