Zobrazeno 1 - 10
of 4 049
pro vyhledávání: '"RNA SECONDARY STRUCTURE"'
Publikováno v:
FEBS Open Bio, Vol 14, Iss 12, Pp 1985-1995 (2024)
Effective circularization of mRNA molecules is a key step for the efficient initiation of translation. Research has shown that the intrinsic separation of the ends of mRNA molecules is rather small, suggesting that intramolecular arrangements could p
Externí odkaz:
https://doaj.org/article/4d967facdb39444cb3365c758a76590e
Subgenomic flaviviral RNAs and human proteins: in silico exploration of anti-host defense mechanisms
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3527-3536 (2024)
Flaviviruses pose significant global health threats, infecting over 300 million people annually. Among their evasion strategies, the production of subgenomic flaviviral RNAs (sfRNAs) from the 3′ UTR of viral genomes is particularly notable. Utilizi
Externí odkaz:
https://doaj.org/article/9c439f4cfa5a4027b04305231bf9c89e
Autor:
Fedor M. Kazanov, Evgenii V. Matveev, Gennady V. Ponomarev, Dmitry N. Ivankov, Marat D. Kazanov
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Recent advancements in experimental and computational methods for RNA secondary structure detection have revealed the crucial role of RNA structural elements in diverse molecular processes within living cells. It has been demonstrated that t
Externí odkaz:
https://doaj.org/article/88bf90bcacc244a19828e967326a455b
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background RNA secondary structural alignment serves as a foundational procedure in identifying conserved structural motifs among RNA sequences, crucially advancing our understanding of novel RNAs via comparative genomic analysis. While vari
Externí odkaz:
https://doaj.org/article/edc36e75fedd42a1a9ba86348eae56e8
Autor:
Sandra Triebel, Kevin Lamkiewicz, Nancy Ontiveros, Blake Sweeney, Peter F. Stadler, Anton I. Petrov, Michael Niepmann, Manja Marz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Hepatitis C virus (HCV) is a plus-stranded RNA virus that often chronically infects liver hepatocytes and causes liver cirrhosis and cancer. These viruses replicate their genomes employing error-prone replicases. Thereby, they routinely gene
Externí odkaz:
https://doaj.org/article/60cac77d8c7c49d1b81ee5d4959f6b3e
Autor:
Peter Simmonds
Publikováno v:
mBio, Vol 15, Iss 12 (2024)
ABSTRACT The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pandemic and post-pandemic periods has been characterized by rapid adaptive changes that confer immune escape and enhanced human-to-human transmissibility.
Externí odkaz:
https://doaj.org/article/69609f81b8694bad81caa5979b935e7e
Autor:
Andrea Vandelli, Laura Broglia, Alexandros Armaos, Riccardo Delli Ponti, Gian Gaetano Tartaglia
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102391- (2024)
RNA modifications play a crucial role in regulating gene expression by altering RNA structure and modulating interactions with RNA-binding proteins (RBPs). In this study, we explore the impact of specific RNA chemical modifications—N6-methyladenosi
Externí odkaz:
https://doaj.org/article/5d570a742177497dac00fd17a6ae3df7
Publikováno v:
F1000Research, Vol 10 (2024)
Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had led to a global pandemic since December 2019. SARS-CoV-2 is a single-stranded RNA virus, which mutates at a higher rate. Multiple works had been done to stud
Externí odkaz:
https://doaj.org/article/a8b7f194f9c541ecb05cff58c0ad2a26
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Uncovering functional genetic variants from an allele-specific perspective is of paramount importance in advancing our understanding of gene regulation and genetic diseases. Recently, various allele-specific events, such as allele
Externí odkaz:
https://doaj.org/article/d105233902ed4ddbaea29c914bce1154
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 481-505 (2024)
Abstract Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expr
Externí odkaz:
https://doaj.org/article/e3f9a0a3fd414444937ad4be2d5c08c9