Zobrazeno 1 - 10
of 208
pro vyhledávání: '"RNA Polymerase Inhibitor"'
Publikováno v:
BioImpacts, Vol 13, Iss 5, Pp 373-382 (2023)
Introduction: Machine learning methods, coupled with a tremendous increase in computer power in recent years, are promising tools in modern drug design and drug repurposing. Methods: Machine learning predictive models, publicly available at chemosoph
Externí odkaz:
https://doaj.org/article/1f476e258737424c85544e1dd4ecd17b
Autor:
Emi Takashita, Shin Murakami, Yoko Matsuzaki, Seiichiro Fujisaki, Hiroko Morita, Shiho Nagata, Misa Katayama, Katsumi Mizuta, Hidekazu Nishimura, Shinji Watanabe, Taisuke Horimoto, Hideki Hasegawa
Publikováno v:
Viruses, Vol 15, Iss 1, p 244 (2023)
The emergence and spread of antiviral-resistant influenza viruses are of great concern. To minimize the public health risk, it is important to monitor antiviral susceptibilities of influenza viruses. Analyses of the antiviral susceptibilities of infl
Externí odkaz:
https://doaj.org/article/23e5cb5f398740bda2910dffc9317b34
Autor:
Soujanya D. Yelamanchi, Archita Mishra, Santosh Kumar Behra, Gayathree Karthikkeyan, Thottethodi Subrahmanya Keshava Prasad, Avadhesha Surolia
Publikováno v:
Metabolites, Vol 12, Iss 6, p 493 (2022)
Mycobacterium tuberculosis (Mtb) is considered to be a devastating pathogen worldwide, affecting millions of people globally. Several drugs targeting distinct pathways are utilized for the treatment of tuberculosis. Despite the monumental efforts bei
Externí odkaz:
https://doaj.org/article/aecd5128789742649ef6c9ae999b5044
Publikováno v:
Antibiotics, Vol 10, Iss 11, p 1294 (2021)
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly resulted in a global pandemic with approximately 4 million deaths. Effective oral antiviral agents are urgently needed to treat coronavirus disease-2019 (CO
Externí odkaz:
https://doaj.org/article/74981b2833ae44b6bb4f9ec78331bb5d
Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections
Autor:
Nathalie Loeper, Simon Graspeuntner, Svea Ledig, Inga Kaufhold, Friederike Hoellen, Andrea Schiefer, Beate Henrichfreise, Kenneth Pfarr, Achim Hoerauf, Kensuke Shima, Jan Rupp
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Ascending Chlamydia trachomatis infection causes functional damage to the fallopian tubes, which may lead to ectopic pregnancy and infertility in women. Treatment failures using the standard regimens of doxycycline and azithromycin have been observed
Externí odkaz:
https://doaj.org/article/985924d0f19a462e98112599ee9abb4a
Autor:
Johan Neyts, Leen Delang, Chenyan Shi, Carmen Mirabelli, Shivaprasad Patil, Kristina Lanko, Jelle Matthijnssens
Publikováno v:
ACS Infectious Diseases. 7:2801-2806
There are currently no antivirals available to treat infection with enterovirus A71 (EV-A71) or any other enterovirus. The extensively studied capsid binders rapidly select for drug-resistant variants. We here explore whether the combination of two d
Autor:
Hiroshi Ohrui, Eiichi Ami
Publikováno v:
ACS Medicinal Chemistry Letters
Great pioneers of nucleic acid chemistry had elucidated nucleic acid functions and structures and developed various antiviral modified nucleoside drugs. It is possible in theory that antiviral modified nucleosides prevent viral replication by inhibit
Publikováno v:
Viruses, Vol 11, Iss 9, p 826 (2019)
Influenza A virus infections cause significant morbidity and mortality, and novel antivirals are urgently needed. Influenza RNA-dependent RNA polymerase (RdRp) activity has been acknowledged as a promising target for novel antivirals. In this study,
Externí odkaz:
https://doaj.org/article/99f34a03b242445396a51910221bcd85
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