Výsledky vyhledávání - "RNA Helicases/genetics"

A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation

Autor: Nele Hug, Stuart Aitken, Dasa Longman, Michaela Raab, Hannah Armes, Abigail R. Mann, Ana Rio-Machin, Jude Fitzgibbon, Kevin Rouault-Pierre, Javier F. Cáceres

Publikováno v: Hug, N, Aitken, S, Raab, M, Armes, H, Mann (nee Wilson), A, Rio-machin, A, Fitzgibbon, J, Rouault-Pierre, K & Caceres, J F 2022, ' A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation ', RNA, vol. 28, no. 9, pp. 1224-1238 . https://doi.org/10.1261/rna.079277.122

The DExD/H-box RNA helicase DHX34 is a Nonsense-mediated decay (NMD) factor that together with core NMD factors co-regulates NMD targets in nematodes and in vertebrates. Here, we show that DHX34 is also associated with the human spliceosomal catalyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bdb207b70cd3ff583ec968ae86f6ec
https://doi.org/10.1261/rna.079277.122

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Antisense transcriptional interference mediates condition-specific gene repression in budding yeast

Autor: Antonia Doyen, Alicia Nevers, Christophe Malabat, Bertrand Néron, Gwenael Badis, Thomas Kergrohen, Alain Jacquier

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2018, 46 (12), pp.6009-6025. ⟨10.1093/nar/gky342⟩
Nucleic Acids Research, 2018, 46 (12), pp.6009-6025. ⟨10.1093/nar/gky342⟩

Pervasive transcription generates many unstable non-coding transcripts in budding yeast. The transcription of such noncoding RNAs, in particular antisense RNAs (asRNAs), has been shown in a few examples to repress the expression of the associated mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6025e7be12b7d285ac756d69d1201269
https://hal.archives-ouvertes.fr/hal-02349600

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Integrator complex plays an essential role in adipose differentiation

Autor: Otani, Y., Nakatsu, Y., Sakoda, H., Fukushima, Toshiaki, Fujishiro, M., Kushiyama, A., Okubo, H., Tsuchiya, Y., Ohno, H., Takahashi, S., Nishimura, F., Kamata, H., Katagiri, H., Asano, T.

Publikováno v: Biochemical and Biophysical Research Communications. 434:197-202

The dynamic process of adipose differentiation involves stepwise expressions of transcription factors and proteins specific to the mature fat cell phenotype. In this study, it was revealed that expression levels of IntS6 and IntS11, subunits of the I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c248139b83614fe3df86f7ccaa2e80
https://doi.org/10.1016/j.bbrc.2013.03.029

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Yeast Sen1 helicase protects the genome from transcription-associated instability

Autor: Wu Wei, Belén Gómez-González, Andrés Aguilera, Lars M. Steinmetz, Nick J. Proudfoot, Hannah E. Mischo, Ana G. Rondón, Pawel Grzechnik

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Mischo, H E, Gómez-González, B, Grzechnik, P, Rondón, A G, Wei, W, Steinmetz, L, Aguilera, A & Proudfoot, N J 2011, ' Yeast Sen1 helicase protects the genome from transcription-associated instability ', Molecular Cell, vol. 41, no. 1, pp. 21-32 . https://doi.org/10.1016/j.molcel.2010.12.007
Molecular Cell
Mischo, H E, Gómez-González, B, Grzechnik, P, Rondón, A G, Wei, W, Steinmetz, L, Aguilera, A & Proudfoot, N J 2011, ' Yeast Sen1 helicase protects the genome from transcription-associated instability ', MOLECULAR CELL, vol. 41, no. 1, pp. 21-32 . https://doi.org/10.1016/j.molcel.2010.12.007

Under a Creative Commons license: Open Access funded by Wellcome Trust.-- et al.
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA polyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d338c620cd36bcc2bb998ed1bc5201c
https://ora.ox.ac.uk/objects/uuid:c053dc0a-f3cb-44c8-9d21-90e0403609d4

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Fail-Safe Transcriptional Termination for Protein-Coding Genes in S. cerevisiae

Autor: Junya Kawauchi, Nick J. Proudfoot, Hannah E. Mischo, Ana G. Rondón

Publikováno v: Molecular Cell
Rondón, A G, Mischo, H E, Kawauchi, J & Proudfoot, N J 2009, ' Fail-safe transcriptional termination for protein-coding genes in S. cerevisiae ', MOLECULAR CELL, vol. 36, no. 1, pp. 88-98 . https://doi.org/10.1016/j.molcel.2009.07.028

Summary Transcription termination of RNA polymerase II (Pol II) on protein-coding genes in S. cerevisiae relies on pA site recognition by 3′ end processing factors. Here we demonstrate the existence of two alternative termination mechanisms that re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac692221d1694e8fee69101a0c51ce8
https://doi.org/10.1016/j.molcel.2009.07.028

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Autor: Andrew Paterson, Neeraj Kumar, Luis Castaño, Jinny Willis, Valdis Pirags, David Altshuler, Farren Briggs, Neil Walker, Ondrej Cinek, Helen Schuilenburg, Francisco Javier Ampudia Blasco, Claire Vandiedonck, Mark A. Hall, Ana M Wägner, Xiaoying Li, Flemming Pociot, Didac Mauricio, Vaidotas Urbanavicius, Jennifer Couper, Adam Kretowski, Deborah Smyth, Professor David Dunger, Federico Vázquez, Ian Nicholson, Ellen Schofield, John Todd, Angela Simpson, Ingrid Kockum, Mikael Knip, Tadej Battelino, Thomas Brodnicki, Patrick Concannon, Jesús Argente, Johnny Ludvigsson, Peter Colman, Gurvinder Kaur, Vincent Plagnol, Oliver Burren, Rohana Abdul Ghani, Marta Hernández, William McLaren, Alessandro Doria, Raquel Corripio, Stephen Rich, Daniel Metzger, Jesper Johannesen, Steven Willi, Cécile JULIER, Vallo Tillmann, Bart Van der Auwera

Publikováno v: Nature genetics

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a new genome-wide association study of T1D, combined in a meta-analysis with two previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5da1ea4d48512559cd190de2484139
https://doi.org/10.1038/ng.381

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Identification of intellectual disability genes in female patients with a skewed X-inactivation pattern

Autor: Fieremans, Nathalie, Van Esch, Hilde, Holvoet, Maureen, Van Goethem, Gert, Devriendt, Koenraad, Rosello, Monica, Mayo, Sonia, Martinez, Francisco, Jhangiani, Shalini, Muzny, Donna M, Gibbs, Richard A, Lupski, James R, Vermeesch, Joris R, Marynen, Peter, Froyen, Guy

Publikováno v: Human mutation

Intellectual disability (ID) is a heterogeneous disorder with an unknown molecular etiology in many cases. Previously, X-linked ID (XLID) studies focused on males because of the hemizygous state of their X chromosome. Carrier females are generally un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::181157feb694cccfaab67686f7e757ff
https://hdl.handle.net/10067/1349350151162165141

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Identification of theClostridium perfringensGenes Involved in the Adaptive Response to Oxidative Stress

Autor: Valérie Briolat, Gilles Reysset

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2002, 184 (9), pp.2333-2343. ⟨10.1128/jb.184.9.2333-2343.2002⟩
Journal of Bacteriology, 2002, 184 (9), pp.2333-2343. ⟨10.1128/jb.184.9.2333-2343.2002⟩

Clostridium perfringensis a ubiquitous gram-positive pathogen that is present in the air, soil, animals, and humans. AlthoughC. perfringensis strictly anaerobic, vegetative and stationary cells can survive in a growth-arrested stage in the presence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffb07ef014e64f098e3e55309beffc9
https://doi.org/10.1128/jb.184.9.2333-2343.2002

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TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA

Autor: Laurent Gauthier, Nathalie Bonnefoy-Berard, Mathieu Blery, Yannis Morel, Isabelle Durand, Ivan Perrot, Christophe Caux, Pierre Garrone, Lena Alexopoulou, Florence Deauvieau, Catherine Massacrier, Giorgio Trinchieri, Nicola Hughes, Nicolas Viaud, Jürg Tschopp, Carine Paturel, Olivier Demaria

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (4), pp.2080-8. ⟨10.4049/jimmunol.1000532⟩
Journal of Immunology, 2010, 185 (4), pp.2080-8. ⟨10.4049/jimmunol.1000532⟩
Journal of Immunology, vol. 185, no. 4, pp. 2080-2088

Cross-talk between NK cells and dendritic cells (DCs) is critical for the potent therapeutic response to dsRNA, but the receptors involved remained controversial. We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec534d69a148c97a95aff2c4a063369
https://hal.archives-ouvertes.fr/hal-00553598

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