Výsledky vyhledávání - "RNA, Messenger / genetics"

Developmental expression of CREB1 and NFATC2 in pig embryos

Publikováno v: Larsen, K E & Callesen, H 2023, ' Developmental expression of CREB1 and NFATC2 in pig embryos ', Molecular Biology Reports, vol. 50, no. 7, pp. 6265-6271 . https://doi.org/10.1007/s11033-023-08501-6

Background: The CREB1 gene encodes the cAMP response element binding protein 1 (CREB1), a leucine zipper transcription factor that regulates cellular gene expression in response to elevated levels of intracellular cAMP. When activated by phosphorylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417e363eeda9a53263bf28696d1939e5
https://doi.org/10.1007/s11033-023-08501-6

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A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation

Autor: Nele Hug, Stuart Aitken, Dasa Longman, Michaela Raab, Hannah Armes, Abigail R. Mann, Ana Rio-Machin, Jude Fitzgibbon, Kevin Rouault-Pierre, Javier F. Cáceres

Publikováno v: Hug, N, Aitken, S, Raab, M, Armes, H, Mann (nee Wilson), A, Rio-machin, A, Fitzgibbon, J, Rouault-Pierre, K & Caceres, J F 2022, ' A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation ', RNA, vol. 28, no. 9, pp. 1224-1238 . https://doi.org/10.1261/rna.079277.122

The DExD/H-box RNA helicase DHX34 is a Nonsense-mediated decay (NMD) factor that together with core NMD factors co-regulates NMD targets in nematodes and in vertebrates. Here, we show that DHX34 is also associated with the human spliceosomal catalyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bdb207b70cd3ff583ec968ae86f6ec
https://doi.org/10.1261/rna.079277.122

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Combined modelling of mRNA decay dynamics and single-molecule imaging in the Drosophila embryo uncovers a role for P-bodies in 5′ to 3′ degradation

Autor: Lauren Forbes Beadle, Jennifer C. Love, Yuliya Shapovalova, Artem Artemev, Magnus Rattray, Hilary L. Ashe

Publikováno v: Plos Biology, 21, 1, pp. 1-29
Plos Biology, 21, 1-29
Forbes-Beadle, L, Love, J, Shapovalova, Y, Artemev, A, Rattray, M & Ashe, H 2023, ' Combined modelling of mRNA decay dynamics and single-molecule imaging in the Drosophila embryo uncovers a role for P-bodies in 5′ to 3′ degradation ', PLoS Biology, vol. 21, no. 1, e3001956 . https://doi.org/10.1371/journal.pbio.3001956

Regulation of mRNA degradation is critical for a diverse array of cellular processes and developmental cell fate decisions. Many methods for determining mRNA half-lives rely on transcriptional inhibition or metabolic labelling. Here, we use a non-inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d4e0e451895ca21b1fce8e6aa71d12

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A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway

Autor: Katsioudi, Georgia, Dreos, René, Arpa, Enes S, Gaspari, Sevasti, Liechti, Angelica, Sato, Miho, Gabriel, Christian H, Kramer, Achim, Brown, Steven A, Gatfield, David

Publikováno v: Science advances, vol. 9, no. 2, pp. eade2828

Nonsense-mediated messenger RNA (mRNA) decay (NMD) has been intensively studied as a surveillance pathway that degrades erroneous transcripts arising from mutations or RNA processing errors. While additional roles in physiological control of mRNA sta

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Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: a prospective cohort study

Autor: Somayeh Khazaei, Ana Bosch, Helena Jernström, Christopher Godina, Edward Visse, Karolin Isaksson, Helga Tryggvadottir, Karin Jirström, Björn Nodin, Signe Borgquist

Publikováno v: Godina, C, Khazaei, S, Tryggvadottir, H, Visse, E, Nodin, B, Jirström, K, Borgquist, S, Bosch, A, Isaksson, K & Jernström, H 2021, ' Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer : A prospective cohort study ', Carcinogenesis, vol. 42, no. 11, pp. 1314-1325 . https://doi.org/10.1093/carcin/bgab090
Carcinogenesis

The prognostic impact of insulin-like growth factor binding protein 7 (IGFBP7) in breast cancer is unclear. Host factors, including lifestyle, anthropometry and metabolic profile, might influence tumor-specific IGFBP7. This study aimed to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc7b49b753aaace2171e6a33b905d5
https://doi.org/10.1093/carcin/bgab090

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A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets

Autor: van de Ven, Koen, Lanfermeijer, Josien, van Dijken, Harry, Muramatsu, Hiromi, Vilas Boas de Melo, Caroline, Lenz, Stefanie, Peters, Florence, Beattie, Mitchell B, Lin, Paulo J C, Ferreira, José A, van den Brand, Judith, van Baarle, Debbie, Pardi, Norbert, de Jonge, Jørgen, VPDC pathologie

Publikováno v: Science advances, 8(50). American Association for the Advancement of Science
Science Advances, 8(50):adc9937. AMER ASSOC ADVANCEMENT SCIENCE

Universal influenza vaccines have the potential to protect against continuously evolving and newly emerging influenza viruses. T cells may be an essential target of such vaccines as they can clear infected cells through recognition of conserved influ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f1e9fa37e0543b8ab7f0fd691e70be
https://doi.org/10.1126/sciadv.adc9937

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Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen

Autor: Marieke Goedhart, Edith Slot, Maria F. Pascutti, Sulima Geerman, Timo Rademakers, Benjamin Nota, Stephan Huveneers, Jaap D. van Buul, Katherine C. MacNamara, Carlijn Voermans, Martijn A. Nolte

Publikováno v: Cells, Vol 11, Iss 55, p 55 (2022)
Cells
Cells, 11(1):55. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, 11(1):55. MDPI Multidisciplinary Digital Publishing Institute
Cells; Volume 11; Issue 1; Pages: 55

Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing DCs in murine BM, we uncovered that they are localized aroun

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https://www.mdpi.com/2073-4409/11/1/55

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NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia

Autor: Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan M. Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R. Isles, David Linden, Marianne Van den Bree, Michael Owen, Jeremy Hall, Adrian J. Harwood

Publikováno v: Translational Psychiatry, 12(1):438. Nature Publishing Group

Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for psychiatric disorders, but the molecular mechanisms that drive this association remain to be determined. EHMT1 is an epigenetic repressor that is causal for Kleefst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19c8d69168f0393e7305de2dc7bbf36
https://doi.org/10.1038/s41398-022-02199-z

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Mutations at a split codon in the GTPase-encoding domain of OPA1 cause dominant optic atrophy through different molecular mechanisms

Autor: Joohyun Park, Paul Richter, Karin Schäferhoff, Tobias B. Haack, Valerio Marino, Nicole Weisschuh, Daniele Dell'Orco

Publikováno v: Human Molecular Genetics. 31:761-774

Exonic (i.e. coding) variants in genes associated with disease can exert pathogenic effects both at the protein and mRNA level, either by altering the amino acid sequence or by affecting pre-mRNA splicing. The latter is often neglected due to the lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a39447722ed87a5dda5614882e1a8e4
https://doi.org/10.1093/hmg/ddab286

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The use of RNA‐based 5'‐aminolevulinate synthase 2 biomarkers in dried blood spots to detect recombinant human erythropoietin microdoses

Autor: Tiia Kuuranne, Holly D. Cox, Angela Rocca, Costas Georgakopoulos, Francesco Loria, Geoffrey D. Miller, Nathan E. Townsend, Nicolas Leuenberger, Daniel Eichner, Sven Christian Voss

Publikováno v: Drug testing and analysis, vol. 14, no. 5, pp. 826-832

The hematological module of the Athlete Biological Passport (ABP) is used for indirect detection of blood manipulations; however, the use of this method to detect doping, such as with microdoses of recombinant human erythropoietin (rhEPO), is problem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d366220c6aa6ea2796582a9f4d2ea0e
https://doi.org/10.1002/dta.3123

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