A11 Induced pluripotent stem cells for basic and translational research on HD

Autor: Peter J. Donovan, Julia A. Kaye, Guo Li Ming, Yiping Shen, Tammy Gillis, Steven Finkbeiner, Tarja A. Juopperi, Y Zhu, James A. Thomson, Allison D. Ebert, E Chighladze, J-h Li, Amanda R. Mason, Christopher A. Ross, Paul J. Kemp, Junying Yu, JH Chiang, Stephen P. Brazier, Alexander William John Harrison, Ranjit Singh Atwal, Ihn Sik Seong, Valentina Castiglioni, Chun Zhong, James F. Gusella, Leslie F. Lock, Elena Cattaneo, Nicolas Arbez, H-E Tseng, RN Cole, WR Kim, Marquis P. Vawter, Elisa Fossale, Hongjun Song, Gayani Batugedara, Georgia Makri, Tamara Ratovitski, Clive N. Svendsen, Alysia Battersby, Virginia B. Mattis, E Watkin, Malcolm Casale, Ar King, Aaron C. Daub, Punita Sharma, Amanda Redfern, Jayalakshmi S. Mysore, Leslie M. Thompson, Russell L. Margolis, Soshana P. Svendsen, David Rushton, Sergey S Akimov, Marco Onorati, Nicholas D. Allen, Vanessa C. Wheeler, Marcy E. MacDonald, Jamshid Arjomand, Sara T. Winokur, X Chen

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 83:A3.2-A4

Background The expression of mutant HTT leads to many cellular alterations, including abnormal vesicle recycling, loss of signalling by brain-derived neurotrophic factor, excitotoxicity, perturbation of Ca 2+ signalling, decreases in intracellular AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc83aaf4fe0cb7630cafcdd3d79831f9
https://doi.org/10.1136/jnnp-2012-303524.11

The role of N-terminal phosphorylation of DGK-θ.

Autor: Barbernitz MX; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Devine LR; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cole RN; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Raben DM; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Physiology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: draben@jhmi.edu.

Publikováno v: Journal of lipid research [J Lipid Res] 2024 Mar; Vol. 65 (3), pp. 100506. Date of Electronic Publication: 2024 Jan 23.

NEDD4L intramolecular interactions regulate its auto and substrate Na V 1.5 ubiquitination.

Autor: Wright KM; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Nathan S; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Jiang H; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Xia W; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Kim H; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA., Chakouri N; Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA., Nwafor JN; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Fossier L; Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA., Srinivasan L; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Chen Z; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Boronina T; Mass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Post J; Mass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Paul S; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cole RN; Mass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Ben-Johny M; Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA., Cole PA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA., Gabelli SB; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: sandra.gabelli@merck.com.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Mar; Vol. 300 (3), pp. 105715. Date of Electronic Publication: 2024 Feb 02.

Proteomic Changes in the Hippocampus after Repeated Explosive-Driven Blasts.

Autor: Iacono D; DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.; Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.; Neuroscience Program, Department of Anatomy, Physiology & Genetics, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF), Inc., Bethesda, Maryland 20817, United States.; Neurodegeneration Disorders Clinic, National Institute of Neurological Disorders and Stroke, NINDS, NIH, Bethesda, Maryland 20814, United States., Hatch K; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, Maryland 20814, United States., Murphy EK; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, Maryland 20814, United States., Cole RN; Mass Spectrometry and Proteomics, Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, United States., Post J; Mass Spectrometry and Proteomics, Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, United States., Leonessa F; Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, Maryland 20814, United States., Perl DP; DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, Maryland 20814, United States.

Publikováno v: Journal of proteome research [J Proteome Res] 2024 Jan 05; Vol. 23 (1), pp. 397-408. Date of Electronic Publication: 2023 Dec 14.

The C-Terminal of Na V 1.7 Is Ubiquitinated by NEDD4L.

Autor: Wright KM; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Jiang H; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Xia W; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Murphy MB; Cytiva, Marlborough, Massachusetts 01752, United States., Boronina TN; Mass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Nwafor JN; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Kim H; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Iheanacho AM; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.; Department of Physiology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Azurmendi PA; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Cole RN; Mass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Cole PA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Gabelli SB; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.

Publikováno v: ACS bio & med chem Au [ACS Bio Med Chem Au] 2023 Oct 13; Vol. 3 (6), pp. 516-527. Date of Electronic Publication: 2023 Oct 13 (Print Publication: 2023).