Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing

Autor: Max Luedemann, Daniela Stadler, Cho-Chin Cheng, Ulrike Protzer, Percy A. Knolle, Sainitin Donakonda

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 799-811 (2022)
Computational and Structural Biotechnology Journal
Comp. Struc. Biotech. J. 20, 799-811 (2022)

Graphical abstract
Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf39d53fae30a82c808044069a25f50d
http://www.sciencedirect.com/science/article/pii/S2001037022000319

Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2

Autor: Zulkar Nain, Mohaimenul Islam Tareq, Abdullah-Al-Mamun, Suza Mohammad Nur, Thamer A. Bouback, Raihan Rahman Imon, Ishtiaq Qadri, Shahedur Rahman, Foysal Ahammad, Saddam Hossen, Rahat Alam, Tomasz M. Karpiński, Abdus Samad, Enamul Kabir Talukder, Sushil Pokhrel

Publikováno v: International Journal of Biological Macromolecules

Angiotensin-converting enzyme 2 (ACE2), also known as peptidyl-dipeptidase A, belongs to the dipeptidyl carboxydipeptidases family has emerged as a potential antiviral drug target against SARS-CoV-2. Most of the ACE2 inhibitors discovered till now ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e497649ef3b10bf02881728e8cfa000
https://doi.org/10.1016/j.ijbiomac.2021.09.146

Screening of inhibitors against SARS-CoV-2 spike protein and their capability to block the viral entry mechanism: A viroinformatics study

Autor: Mohd Imran Khan, Taehwan Park, Abd El Aziem Farouk, Saqer S. Alotaibi, Jae June Dong, Mohammad Hassan Baig

Publikováno v: Saudi Journal of Biological Sciences, Vol 28, Iss 6, Pp 3262-3269 (2021)
Saudi Journal of Biological Sciences

SARS-CoV-2, previously named 2019 novel coronavirus (2019-nCoV), has been associated with the global pandemic of acute respiratory distress syndrome. First reported in December 2019 in the Wuhan province of China, this new RNA virus has several folds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac475456e9d058c0a72cdc720d4a9da
http://www.sciencedirect.com/science/article/pii/S1319562X21001388

Transglutaminase-Mediated Cross-Linking of Tropoelastin to Fibrillin Stabilises the Elastin Precursor Prior to Elastic Fibre Assembly

Autor: Helena Newandee, Anthony S. Weiss, Clair Baldock, Jennifer Thomson, Michael P. Lockhart-Cairns, Anna Tarakanova

Publikováno v: 'Journal of Molecular Biology ', vol: 432, pages: 5736-5751 (2020)
Journal of Molecular Biology

Elastic fibres are essential components of all mammalian elastic tissues such as blood vessels, lung and skin, and are critically important for the mechanical properties they endow. The main components of elastic fibres are elastin and fibrillin, whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1ad1c9ce6844fc836659e007b8c8ef
https://doi.org/10.1016/j.jmb.2020.08.023

Is amyloid fibrillation related to 3D domain swapping for the C-terminal domain of SARS-CoV main protease?

Autor: Zhiliang Yuan, Zhi Qu, Bo Duan, Tianyi Wang, Jiajun Xu, Bin Xia

Publikováno v: International Journal of Biological Macromolecules

The C-terminal domain of SARS-CoV main protease (Mpro-C) can form 3D domain-swapped dimer by exchanging the α1-helices fully buried inside the protein hydrophobic core, under non-denaturing conditions. Here, we report that Mpro-C can also form amylo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bea496e0a0f54c5901fdf5c865e5409
https://pubmed.ncbi.nlm.nih.gov/34953805