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Autor:
Tiphanie Pruvost, Magali Mathieu, Steven Dubois, Bernard Maillère, Emmanuelle Vigne, Hervé Nozach
Publikováno v:
mAbs
mAbs, 2023, 15 (1), pp.2175311. ⟨10.1080/19420862.2023.2175311⟩
mAbs, 2023, 15 (1), pp.2175311. ⟨10.1080/19420862.2023.2175311⟩
International audience; Delineating the precise regions on an antigen that are targeted by antibodies has become a key step for the development of antibody therapeutics. X-ray crystallography and cryogenic electron microscopy are considered the gold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476895ffc39796bda9de5d41b55bca49
https://doi.org/10.1080/19420862.2023.2175311
https://doi.org/10.1080/19420862.2023.2175311
Autor:
Suchetana Gupta, Ditipriya Mallick, Kumarjeet Banerjee, Shrimon Mukherjee, Soumyadev Sarkar, Sonny TM Lee, Partha Basuchowdhuri, Siddhartha S Jana
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 766-778 (2022)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
The clinical manifestation of the recent pandemic COVID-19, caused by the novel SARS-CoV-2 virus, varies from mild to severe respiratory illness. Although environmental, demographic and co-morbidity factors have an impact on t
The clinical manifestation of the recent pandemic COVID-19, caused by the novel SARS-CoV-2 virus, varies from mild to severe respiratory illness. Although environmental, demographic and co-morbidity factors have an impact on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77e75e84ff2110441d6e92dcaabf7e8
http://www.sciencedirect.com/science/article/pii/S2001037022000241
http://www.sciencedirect.com/science/article/pii/S2001037022000241
Autor:
Jian-Guang Luo, Tianyu Zhu, Chen Chen, Yi Zhang, Hao Zhang, Dong-Rong Zhu, Xiao-Qin Liu, Ling-Yi Kong, Chao Han, Sifang Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 246-261 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3543b6d3266f2b136393cdedb4c3da23
http://www.sciencedirect.com/science/article/pii/S2211383521002203
http://www.sciencedirect.com/science/article/pii/S2211383521002203
Autor:
Max Luedemann, Daniela Stadler, Cho-Chin Cheng, Ulrike Protzer, Percy A. Knolle, Sainitin Donakonda
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 799-811 (2022)
Computational and Structural Biotechnology Journal
Comp. Struc. Biotech. J. 20, 799-811 (2022)
Computational and Structural Biotechnology Journal
Comp. Struc. Biotech. J. 20, 799-811 (2022)
Graphical abstract
Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of S
Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf39d53fae30a82c808044069a25f50d
http://www.sciencedirect.com/science/article/pii/S2001037022000319
http://www.sciencedirect.com/science/article/pii/S2001037022000319
Autor:
Zulkar Nain, Mohaimenul Islam Tareq, Abdullah-Al-Mamun, Suza Mohammad Nur, Thamer A. Bouback, Raihan Rahman Imon, Ishtiaq Qadri, Shahedur Rahman, Foysal Ahammad, Saddam Hossen, Rahat Alam, Tomasz M. Karpiński, Abdus Samad, Enamul Kabir Talukder, Sushil Pokhrel
Publikováno v:
International Journal of Biological Macromolecules
Angiotensin-converting enzyme 2 (ACE2), also known as peptidyl-dipeptidase A, belongs to the dipeptidyl carboxydipeptidases family has emerged as a potential antiviral drug target against SARS-CoV-2. Most of the ACE2 inhibitors discovered till now ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e497649ef3b10bf02881728e8cfa000
https://doi.org/10.1016/j.ijbiomac.2021.09.146
https://doi.org/10.1016/j.ijbiomac.2021.09.146
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b197d7e1bd61447a9d7a45da0a56387
https://doi.org/10.1016/j.apsb.2021.03.011
https://doi.org/10.1016/j.apsb.2021.03.011
Autor:
Mohd Imran Khan, Taehwan Park, Abd El Aziem Farouk, Saqer S. Alotaibi, Jae June Dong, Mohammad Hassan Baig
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 6, Pp 3262-3269 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
SARS-CoV-2, previously named 2019 novel coronavirus (2019-nCoV), has been associated with the global pandemic of acute respiratory distress syndrome. First reported in December 2019 in the Wuhan province of China, this new RNA virus has several folds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac475456e9d058c0a72cdc720d4a9da
http://www.sciencedirect.com/science/article/pii/S1319562X21001388
http://www.sciencedirect.com/science/article/pii/S1319562X21001388
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1355-1361 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase, sirtuin 6 (SIRT6) has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdd9c62c46a651b641697885c98d387
http://www.sciencedirect.com/science/article/pii/S2211383520307218
http://www.sciencedirect.com/science/article/pii/S2211383520307218
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3708-3719 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4 million death in 2019, alongside 10 million new infections. Drug resistance is a growing issue, with multi-drug resistant infections repres
Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4 million death in 2019, alongside 10 million new infections. Drug resistance is a growing issue, with multi-drug resistant infections repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0720f11685fc30f1feb60ea50745fc
http://www.sciencedirect.com/science/article/pii/S2001037021002725
http://www.sciencedirect.com/science/article/pii/S2001037021002725