Zobrazeno 1 - 4
of 4
pro vyhledávání: '"RM0260"'
Autor:
Khondaker Miraz Rahman, Elisabeth Jane Walsby, Christopher Fegan, David B Corcoran, David Edwin Thurston, Chris Pepper, Thomas R. Lewis, Andrea Pepper, Peter Giles, Kevin E. Ashelford
Publikováno v:
Lewis, T, Corcoran, D B, Thurston, D E, J. Giles, P, Ashelford, K, Walsby, E J, Fegan, C D, Pepper, A G S, Rahman, K M & Pepper, C 2020, ' Novel pyrrolobenzodiazepine (PBD) benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers ', Haematologica, vol. Early view, 238584 . https://doi.org/10.3324/haematol.2019.238584
Haematologica
Haematologica
Chronic lymphocytic leukemia (CLL) and multiple myeloma are incurable hematologic malignancies that are pathologically linked with aberrant nuclear factor-kappa B (NF-κB) activation. In this study, we identified a group of novel C8-linked benzofused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1c623341d4fb920734871ff63b5a08
Autor:
Andreas C. Joerger, Bradley Springett, Alan R. Fersht, Felix A. Dingler, Lorena Verduci, Matthias R. Bauer, Ketan J. Patel, Rhiannon N. Jones, John Spencer, Raysa Khan Tareque
Publikováno v:
Future Medicinal Chemistry
Future Med Chem
Future Med Chem
Aim: The p53 cancer mutation Y220C creates a conformationally unstable protein with a unique elongated\ud surface crevice that can be targeted by molecular chaperones. We report the structure-guided optimization\ud of the carbazole-based stabilizer P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6730cd1f62e5fc2066d75c60511b9f
Autor:
Roger von Moos, R. Wei, Donald L. Patrick, Lesley Fallowfield, Yi Qian, Katarina Öhrling, Charles S. Cleeland
Publikováno v:
Supportive Care in Cancer. 23:1157-1168
Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients. The most commonly used pain asses
Autor:
Jenkins, Valerie, Thwaites, Ryan, Cercignani, Mara, Sacre, Sandra, Harrison, Neil, Whiteley-Jones, Hefina, Mullen, Lisa, Chamberlain, Giselle, Davies, Kevin, Zammit, Charles, Matthews, Lucy, Harder, Helena
Background: Women receiving chemotherapy treatment for breast cancer may experience problems with their memory and attention (cognition), which is distressing and interferes with quality of life. It is unclear what causes or contributes to the proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::02329ce41f38a2f4e14bba305908c324
http://hdl.handle.net/10044/1/57341
http://hdl.handle.net/10044/1/57341