Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study

Autor: WD Thompson, RM Reynolds, RN Beaumont, NM Warrington, J Tyrrell, AR Wood, DM Evans, TJ McDonald, AH Hattersley, RM Freathy, DA Lawlor, MC Borges

Publikováno v: BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-11 (2024)

Abstract Background Observational studies and randomized controlled trials have found evidence that higher maternal circulating cortisol levels in pregnancy are associated with lower offspring birth weight. However, it is possible that the observatio

Externí odkaz: https://doaj.org/article/184b224809554cf29e490e6fb1d795b3

Multi-ancestry Genome Wide Association Study Meta-analysis of Non-syndromic Orofacial Clefts.

Autor: Jia Z, Mukhopadhyay N, Yang Z, Butali A, Sun J, You Y, Yao M, Zhen Q, Ma J, He M, Pan Y, Alade A, Wang Y, Olujitan M, Qi M, Adeyemo WL, Buxó CJ, Gowans LJJ, Eshete M, Huang Y, Li C, Leslie EJ, Wang L, Bian Z, Carlson JC, Shi B, Weinberg SM, Murray JC, Sun L, Marazita ML, Freathy RM, Beaumont RN

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Dec 13. Date of Electronic Publication: 2024 Dec 13.

Exploring and Accounting for Genetically Driven Effect Heterogeneity in Mendelian Randomization.

Autor: Jaitner A; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Tsaneva-Atanasova K; Department of Mathematics and Statistics, Faculty of Environment, Science and Economy, University of Exeter, Exeter, UK.; EPSRC Hub for Quantitative Modelling in Healthcare University of Exeter, Exeter, UK., Freathy RM; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Bowden J; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.; Novo Nordisk Research Centre Oxford, Oxford, UK.

Publikováno v: Genetic epidemiology [Genet Epidemiol] 2025 Jan; Vol. 49 (1), pp. e22587. Date of Electronic Publication: 2024 Sep 22.

Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.

Autor: Bradfeld JP; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Kember RL; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Ulrich A; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Balkhiyarova Z; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; People-Centred Artifcial Intelligence Institute, University of Surrey, Guildford, UK., Alyass A; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada., Aris IM; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, 02215, USA., Bell JA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Broadaway KA; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Chen Z; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, 90032, USA., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Davies NM; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Fernandez-Orth D; ISGlobal, Barcelona, Spain., Bustamante M; ISGlobal, Barcelona, Spain., Fore R; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, 02215, USA., Ganguli A; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Heiskala A; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Íñiguez C; Department of Statistics and Computational Research, Universitat de València, Valencia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain., Kobes S; Phoenix Epidemiology and Clinical Research Center, NIDDK, NIH, Bethesda, USA., Leinonen J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Lowry E; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Lyytikainen LP; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, 33521, Tampere, Finland., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Schnurr TM; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Have CT; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Strachan DP; Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK., Thiering E; Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic and Nutritional Medicine, Dr. Von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Vogelezang S; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Wade KH; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK., Wang CA; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Callaghan, NSW, 2308, Australia.; Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Holm LA; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Pediatrics, The Children's Obesity Clinic, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Chesi A; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Choong C; Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia., Cruz M; Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Elliott P; MRC Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, UK., Franks S; Institute of Reproductive & Developmental Biology, Imperial College London, London, UK., Frithiof-Bøjsøe C; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Pediatrics, The Children's Obesity Clinic, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Gauderman WJ; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, 90032, USA., Glessner JT; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Gilsanz V; Center for Endocrinology, Diabetes & Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, USA., Griesman K; Haverford College, Haverford, PA, USA., Hanson RL; Phoenix Epidemiology and Clinical Research Center, NIDDK, NIH, Bethesda, USA., Kaakinen M; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK.; Institute of Reproductive & Developmental Biology, Imperial College London, London, UK., Kalkwarf H; Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH, USA., Kelly A; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Division of Endocrinology & Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Kindler J; College of Family and Consumer Sciences, University of Georgia, Athens, GA, USA., Kähönen M; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, 33521, Tampere, Finland., Lanca C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Lappe J; Department of Medicine and College of Nursing, Creighton University School of Medicine, Omaha, NB, USA., Lee NR; USC-Ofce of Population Studies Foundation, Inc, University of San Carlos, Cebu, Philippines., McCormack S; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Division of Endocrinology & Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Mentch FD; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Mitchell JA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Mononen N; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center - Tampere, Tampere University, 33014, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Oken E; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, 02215, USA.; Department of Nutrition, Harvard T.H Chan School of Public Health, Boston, MA, 02115, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Baier LJ; Phoenix Epidemiology and Clinical Research Center, NIDDK, NIH, Bethesda, USA., van Beijsterveldt T; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands., de Geus E; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Guxens M; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Eriksson JG; Institute of Clinical Medicine Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Department of Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Gilliland FD; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, 90032, USA., Hansen T; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Hardy R; Cohort and Longitudinal Studies Enhancement Resources (CLOSER), UCL Institute of Education, London, UK., Hivert MF; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, 02215, USA., Holm JC; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Pediatrics, The Children's Obesity Clinic, Copenhagen University Hospital Holbæk, Holbæk, Denmark.; The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jaddoe VWV; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Järvelin MR; Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, School of Public Health, MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK.; Unit of Primary Health Care, Oulu University Hospital, OYS, Kajaanintie 50, 90220, Oulu, Finland., Lehtimäki T; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center - Tampere, Tampere University, 33014, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland., Mackey DA; Lions Eye Institute, Centre for Ophthalmology and Visual Science, Centre for Eye Research Australia, University of Western Australia, Perth, WA, Australia., Meyre D; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.; Inserm UMR_S1256 Nutrition-Genetics-Environmental Risk Exposure, University of Lorraine, Nancy, France.; Department of Biochemistry-Molecular Biology-Nutrition, University Hospital Centre of Nancy, Nancy, France., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Mykkänen J; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Oberfeld S; Division of Pediatric Endocrinology, Columbia University Medical Center, New York, NY, USA., Pennell CE; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Callaghan, NSW, 2308, Australia.; Hunter Medical Research Institute, Newcastle, NSW, 2305, Australia.; Department of Maternity and Gynaecology, John Hunter Hospital, Newcastle, NSW, 2305, Australia., Perry JRB; Metabolic Research Laboratory, School of Clinical Medicine, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.; MRC Epidemiology Unit, School of Clinical Medicine, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Raitakari O; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Rivadeneira F; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Saw SM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Sebert S; Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, School of Public Health, MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK., Shepherd JA; Department of Epidemiology and Population Science, University of Hawaii Cancer Center, Honolulu, HI, USA., Standl M; Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany., Sørensen TIA; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Torrent M; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Fundació Institut d'Investigació Sanitària Illes Balears - IdISBa, Palma, Spain., Willemsen G; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Hypponen E; UCL Great Ormond Street Institute of Child Health, London, UK.; Australian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Power C; UCL Great Ormond Street Institute of Child Health, London, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Current Address: Genentech, 1 DNA Way, San Francisco, CA, 94080, USA., Freathy RM; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX2 5DW, UK., Widén E; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Prokopenko I; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK.; People-Centred Artifcial Intelligence Institute, University of Surrey, Guildford, UK.; UMR 8199 - EGID, Institut Pasteur de Lille, CNRS, University of Lille, 59000, Lille, France., Voight BF; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zemel BS; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Grant SFA; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. grants@email.chop.edu.; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. grants@email.chop.edu.; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. grants@email.chop.edu.; Division of Endocrinology & Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. grants@email.chop.edu.; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. grants@email.chop.edu.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. grants@email.chop.edu., Cousminer DL; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. diana.l.cousminer@gsk.com.; Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. diana.l.cousminer@gsk.com.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. diana.l.cousminer@gsk.com.; Currently Employed By GlaxoSmithKline, 1250 S Collegeville Rd, Collegeville, PA, 19426, USA. diana.l.cousminer@gsk.com.

Publikováno v: Genome biology [Genome Biol] 2024 May 21; Vol. 25 (1), pp. 129. Date of Electronic Publication: 2024 May 21.

Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling.

Autor: Kentistou KA; MRC Epidemiology Unit, Box 285 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Lim BEM; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Kaisinger LR; MRC Epidemiology Unit, Box 285 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Steinthorsdottir V; deCODE genetics/Amgen, Inc., 102 Reykjavik, Iceland., Sharp LN; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Patel KA; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Tragante V; deCODE genetics/Amgen, Inc., 102 Reykjavik, Iceland., Hawkes G; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Gardner EJ; MRC Epidemiology Unit, Box 285 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Olafsdottir T; deCODE genetics/Amgen, Inc., 102 Reykjavik, Iceland., Wood AR; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Zhao Y; MRC Epidemiology Unit, Box 285 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Thorleifsson G; deCODE genetics/Amgen, Inc., 102 Reykjavik, Iceland., Day FR; MRC Epidemiology Unit, Box 285 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK., Ozanne SE; MRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Hattersley AT; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., O'Rahilly S; MRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Stefansson K; deCODE genetics/Amgen, Inc., 102 Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland., Ong KK; MRC Epidemiology Unit, Box 285 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Beaumont RN; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Perry JRB; MRC Epidemiology Unit, Box 285 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.; MRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Freathy RM; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Apr 03. Date of Electronic Publication: 2024 Apr 03.