[Effect of Catechol-O-methyltransferase deficiency on reinforcing effects of cocaine (experimental study)]

Autor: Lv, Mus, Oa, Dravolina, Bespalov AIu, Käenmäki M, Talka R, Outi Salminen, Rk, Tuominen, Pt, Männistiö, Ee, Zvartau

Publikováno v: Europe PubMed Central

Catechol-O-methyltransferase (COMT) remains an important regulatory element in prefrontal cortex dopamine homeostasis. The literature data suggest that individual differences in COMT activity (Val158Met polymorphism) might have indirect downstream ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c02d81a95ff249a430308f6074f85b0d
http://europepmc.org/abstract/med/23011431

Short and long term regulation of catecholamine biosynthetic enzymes by angiotensin in cultured adrenal medullary cells. Molecular mechanisms and nature of second messenger systems

Autor: Mk, Stachowiak, Hk, Jiang, Am, Poisner, Rk, Tuominen, Jau-Shyong Hong

Publikováno v: Europe PubMed Central
ResearcherID

The purpose of this study was to examine the effects of angiotensin on the enzyme activities and gene expression of two catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT), in bovine adrenal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::26a99fab5a74050705bf231a9bf3ce87
http://europepmc.org/abstract/med/1968464

Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists.

Autor: Lautala S; Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Provenzani R; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Tarvainen I; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Sirna K; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Karhu ST; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Grazhdankin E; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Lehtinen AK; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Sa'd H; Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.; School of Pharmacy, The University of Jordan, Queen Rania Street, 11942 Amman, Jordan., Koivuniemi A; Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Xhaard H; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Tuominen RK; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Talman V; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Bunker A; Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Apr 13; Vol. 66 (7), pp. 4588-4602. Date of Electronic Publication: 2023 Apr 03.

Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats.

Autor: Renko JM; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Mahato AK; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Visnapuu T; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Valkonen K; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Karelson M; Institute of Chemistry, University of Tartu, Tartu, Estonia., Voutilainen MH; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Saarma M; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Tuominen RK; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Sidorova YA; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Publikováno v: Journal of Parkinson's disease [J Parkinsons Dis] 2021; Vol. 11 (3), pp. 1023-1046.

Rigorous Computational Study Reveals What Docking Overlooks: Double Trouble from Membrane Association in Protein Kinase C Modulators.

Autor: Lautala S; Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, FI-00014 Helsinki, Finland., Provenzani R; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, FI-00014 Helsinki, Finland., Koivuniemi A; Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, FI-00014 Helsinki, Finland., Kulig W; Department of Physics, University of Helsinki, P.O. Box 64, Gustaf Hällströmin katu 2, FI-00014 Helsinki, Finland., Talman V; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, FI-00014 Helsinki, Finland.; National Heart and Lung Institute, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom., Róg T; Department of Physics, University of Helsinki, P.O. Box 64, Gustaf Hällströmin katu 2, FI-00014 Helsinki, Finland., Tuominen RK; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, FI-00014 Helsinki, Finland., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, FI-00014 Helsinki, Finland., Bunker A; Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, FI-00014 Helsinki, Finland.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2020 Nov 23; Vol. 60 (11), pp. 5624-5633. Date of Electronic Publication: 2020 Sep 21.