Plasma proteomic associations with genetics and health in the UK Biobank.

Autor: Sun BB; Translational Sciences, Research & Development, Biogen, Cambridge, MA, USA. bbsun92@outlook.com., Chiou J; Internal Medicine Research Unit, Worldwide Research, Development and Medical, Pfizer, Cambridge, MA, USA., Traylor M; Human Genetics Centre of Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Benner C; Genentech, San Francisco, CA, USA., Hsu YH; Amgen Research, Cambridge, MA, USA., Richardson TG; Human Genetics Centre of Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK.; Genomic Sciences, GlaxoSmithKline, Stevenage, UK., Surendran P; Genomic Sciences, GlaxoSmithKline, Stevenage, UK., Mahajan A; Genentech, San Francisco, CA, USA., Robins C; Genomic Sciences, GlaxoSmithKline, Collegeville, PA, USA., Vasquez-Grinnell SG; Bristol Myers Squibb, Princeton, NJ, USA., Hou L; Population Analytics, Janssen Research & Development, Spring House, PA, USA., Kvikstad EM; Bristol Myers Squibb, Princeton, NJ, USA., Burren OS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Davitte J; Genomic Sciences, GlaxoSmithKline, Collegeville, PA, USA., Ferber KL; Biostatistics, Research and Development, Biogen, Cambridge, MA, USA., Gillies CE; Regeneron Genetics Center, Tarrytown, NY, USA., Hedman ÅK; External Science and Innovation Target Sciences, Worldwide Research, Development and Medical, Pfizer, Stockholm, Sweden., Hu S; Human Genetics Centre of Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Lin T; Analytics and Data Sciences, Biogen, Cambridge, MA, USA., Mikkilineni R; Data Science Institute, Takeda Development Center Americas, Cambridge, MA, USA., Pendergrass RK; Genentech, San Francisco, CA, USA., Pickering C; UK Biobank, Stockport, UK., Prins B; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Baird D; Translational Sciences, Research & Development, Biogen, Cambridge, MA, USA., Chen CY; Translational Sciences, Research & Development, Biogen, Cambridge, MA, USA., Ward LD; Alnylam Human Genetics, Discovery & Translational Research, Alnylam Pharmaceuticals, Cambridge, MA, USA., Deaton AM; Alnylam Human Genetics, Discovery & Translational Research, Alnylam Pharmaceuticals, Cambridge, MA, USA., Welsh S; UK Biobank, Stockport, UK., Willis CM; Alnylam Human Genetics, Discovery & Translational Research, Alnylam Pharmaceuticals, Cambridge, MA, USA., Lehner N; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Arnold M; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Wörheide MA; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Suhre K; Bioinformatics Core, Weill Cornell Medicine-Qatar, Doha, Qatar., Kastenmüller G; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Sethi A; Calico Life Sciences, San Francisco, CA, USA., Cule M; Calico Life Sciences, San Francisco, CA, USA., Raj A; Calico Life Sciences, San Francisco, CA, USA., Burkitt-Gray L; UK Biobank, Stockport, UK., Melamud E; Calico Life Sciences, San Francisco, CA, USA., Black MH; Population Analytics, Janssen Research & Development, Spring House, PA, USA., Fauman EB; Internal Medicine Research Unit, Worldwide Research, Development and Medical, Pfizer, Cambridge, MA, USA., Howson JMM; Human Genetics Centre of Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Kang HM; Regeneron Genetics Center, Tarrytown, NY, USA., McCarthy MI; Genentech, San Francisco, CA, USA., Nioi P; Alnylam Human Genetics, Discovery & Translational Research, Alnylam Pharmaceuticals, Cambridge, MA, USA., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Department of Medicine, University of Melbourne, Austin Health, Melbourne, Victoria, Australia., Scott RA; Genomic Sciences, GlaxoSmithKline, Stevenage, UK., Smith EN; Takeda Development Center Americas, San Diego, CA, USA., Szalma S; Takeda Development Center Americas, San Diego, CA, USA., Waterworth DM; Immunology, Janssen Research & Development, Spring House, PA, USA., Mitnaul LJ; Regeneron Genetics Center, Tarrytown, NY, USA., Szustakowski JD; Bristol Myers Squibb, Princeton, NJ, USA., Gibson BW; Amgen Research, Cambridge, MA, USA., Miller MR; Internal Medicine Research Unit, Worldwide Research, Development and Medical, Pfizer, Cambridge, MA, USA., Whelan CD; Translational Sciences, Research & Development, Biogen, Cambridge, MA, USA. christopherdwhelan@outlook.com.; Neuroscience Data Science, Janssen Research & Development, Cambridge, MA, USA. christopherdwhelan@outlook.com.

Publikováno v: Nature [Nature] 2023 Oct; Vol. 622 (7982), pp. 329-338. Date of Electronic Publication: 2023 Oct 04.

Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population.

Autor: Kurki MI; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Karjalainen J; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Palta P; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Sipilä TP; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kristiansson K; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Donner KM; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Reeve MP; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Laivuori H; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Center for Child, Adolescent and Maternal Health, University of Tampere, Tampere, Finland., Aavikko M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kaunisto MA; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Loukola A; Helsinki Biobank, University of Helsinki and Hospital District of Helsinki and Uusimaa, Helsinki, Finland., Lahtela E; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Mattsson H; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Laiho P; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Della Briotta Parolo P; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Lehisto AA; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kanai M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Mars N; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Rämö J; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kiiskinen T; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Heyne HO; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Digital Health Center, Hasso Plattner Institute for Digital Engineering, University of Potsdam Potsdam, Potsdam, Germany.; Hasso Plattner Institute for Digital Health at Mount Sinai, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Veerapen K; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Rüeger S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Lemmelä S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Zhou W; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ruotsalainen S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Pärn K; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Hiekkalinna T; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Koskelainen S; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Paajanen T; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Llorens V; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Gracia-Tabuenca J; TAUCHI Research Center, Faculty of Information Technology and Communication Sciences, Tampere University, Tampere, Finland., Siirtola H; TAUCHI Research Center, Faculty of Information Technology and Communication Sciences, Tampere University, Tampere, Finland., Reis K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Elnahas AG; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Sun B; Translational Biology, Research and Development, Biogen, Cambridge, MA, USA.; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Foley CN; Optima Partners, Edinburgh, UK.; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Aalto-Setälä K; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Alasoo K; Institute of Computer Science, University of Tartu, Tartu, Estonia., Arvas M; Finnish Red Cross Blood Service, Helsinki, Finland., Auro K; GlaxoSmithKline, Espoo, Finland., Biswas S; Bristol Myers Squibb, New York, NY, USA., Bizaki-Vallaskangas A; Tampere University Hospital and Tampere University, Tampere, Finland., Carpen O; Helsinki Biobank, University of Helsinki and Hospital District of Helsinki and Uusimaa, Helsinki, Finland., Chen CY; Biogen, Cambridge, MA, USA., Dada OA; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Ding Z; Boehringer Ingelheim, Ingelheim am Rhein, Germany., Ehm MG; GlaxoSmithKline, Collegeville, PA, USA., Eklund K; Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.; Orton Orthopedic Hospital, Helsinki, Finland., Färkkilä M; Abdominal Center, Helsinki University Hospital, Helsinki University, Helsinki, Finland., Finucane H; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ganna A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ghazal A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Graham RR; Maze Therapeutics, South San Francisco, CA, USA., Green EM; Maze Therapeutics, South San Francisco, CA, USA., Hakanen A; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Hautalahti M; FINBB, Finnish Biobank Cooperative, Helsinki, Finland., Hedman ÅK; Pfizer, New York, NY, USA.; Department of Medicine, Karolinska Institute, Solna, Sweden., Hiltunen M; Clinical Biobank Tampere, Tampere University and Tampere University Hospital, Tampere, Finland., Hinttala R; Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Oulu University Hospital, Oulu, Finland., Hovatta I; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Hu X; Pfizer, New York, NY, USA., Huertas-Vazquez A; Merck & Co, Kenilworth, NJ, USA., Huilaja L; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Hunkapiller J; Genentech, San Francisco, CA, USA., Jacob H; AbbVie, Chicago, IL, USA., Jensen JN; Boehringer Ingelheim, Ingelheim am Rhein, Germany., Joensuu H; Helsinki University Hospital and University of Helsinki, Helsinki, Finland., John S; Biogen, Cambridge, MA, USA., Julkunen V; Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland., Jung M; Boehringer Ingelheim, Ingelheim am Rhein, Germany., Junttila J; Northern Finland Biobank Borealis, University of Oulu, Northern Ostrobothnia Hospital District, Oulu, Finland., Kaarniranta K; Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland.; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Kähönen M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Kajanne R; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kallio L; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Kälviäinen R; Epilepsy Center, Kuopio University Hospital, Kuopio, Finland.; Department of Neurology, University of Eastern Finland, Kuopio, Finland., Kaprio J; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Kerimov N; Institute of Computer Science, University of Tartu, Tartu, Estonia., Kettunen J; Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Computational Medicine, Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Kilpeläinen E; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kilpi T; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Klinger K; Translational Sciences, Sanofi R&D, Framingham, MA, USA., Kosma VM; Biobank of Eastern Finland, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Kuopio T; Central Finland Biobank, Central Finland Health Care District, Jyväskylä, Finland., Kurra V; Department of Clinical Genetics, Tampere University Hospital, Tampere, Finland.; Department of Clinical Genetics, Faculty of Medicine and Health Technology, Tampere, Finland., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Laukkanen J; Central Finland Biobank, Central Finland Health Care District, Jyväskylä, Finland.; Department of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Lawless N; Boehringer Ingelheim, Ingelheim am Rhein, Germany., Liu A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Longerich S; Merck & Co, Kenilworth, NJ, USA., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mäkelä J; FINBB, Finnish Biobank Cooperative, Turku, Finland., Mäkitie A; Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, Helsinki, Finland.; Helsinki University Hospital, Helsinki, Finland., Malarstig A; Pfizer, Cambridge, MA, USA.; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden., Mannermaa A; Biobank of Eastern Finland, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Maranville J; Bristol Myers Squibb, New York, NY, USA., Matakidou A; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Meretoja T; Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Mozaffari SV; Maze Therapeutics, South San Francisco, CA, USA., Niemi MEK; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Niemi M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; TAUCHI Research Center & Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Niiranen T; Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; Turku University Hospital and University of Turku, Turku, Finland., O Donnell CJ; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Obeidat ME; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Okafo G; Boehringer Ingelheim, Ingelheim am Rhein, Germany., Ollila HM; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Palomäki A; Turku University Hospital and University of Turku, Turku, Finland., Palotie T; Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki, Finland.; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland., Partanen J; Finnish Red Cross Blood Service, Helsinki, Finland.; Finnish Hematological Biobank, Helsinki, Finland., Paul DS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Pelkonen M; Department of Pulmonary Diseases, Kuopio University Hospital, Kuopio, Finland., Pendergrass RK; Genentech, San Francisco, CA, USA., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Pitkäranta A; Department of Otorhinolaryngology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Platt A; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Pulford D; GlaxoSmithKline, Stevenage, UK., Punkka E; Helsinki Biobank, University of Helsinki and Hospital District of Helsinki and Uusimaa, Helsinki, Finland., Pussinen P; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland., Raghavan N; Merck & Co, Kenilworth, NJ, USA., Rahimov F; AbbVie, Chicago, IL, USA., Rajpal D; Translational Sciences, Sanofi R&D, Framingham, MA, USA., Renaud NA; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Riley-Gillis B; AbbVie, Chicago, IL, USA., Rodosthenous R; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Saarentaus E; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Salminen A; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland., Salminen E; Helsinki University Hospital, Helsinki, Finland.; Department of Clinical Genetics, HUSLAB, HUS Diagnostic Center, University of Helsinki, Helsinki, Finland., Salomaa V; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Schleutker J; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Serpi R; Northern Finland Biobank Borealis, University of Oulu, Northern Ostrobothnia Hospital District, Oulu, Finland., Shen HY; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Siegel R; Novartis Institutes for BioMedical Research, Basel, Switzerland., Silander K; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Siltanen S; Finnish Clinical Biobank Tampere, Tampere University and Tampere University Hospital, Tampere, Finland., Soini S; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Soininen H; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Sul JH; Merck & Co, Kenilworth, NJ, USA., Tachmazidou I; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Tasanen K; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Tienari P; Department of Neurology, Helsinki University Hospital, Helsinki, Finland.; Translational Immunology, Research Programs Unit, University of Helsinki, Helsinki, Finland., Toppila-Salmi S; Department of Allergy, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Tukiainen T; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Tuomi T; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Abdominal Center, Endocrinology, Helsinki University Hospital, Helsinki, Finland.; Folkhalsan Research Center, Helsinki, Finland.; Research Program of Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Turunen JA; Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Eye Genetics Group, Folkhälsan Research Center, Helsinki, Finland., Ulirsch JC; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vaura F; Finnish Institute for Health and Welfare (THL), Helsinki, Finland.; University of Turku, Turku, Finland., Virolainen P; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Waring J; AbbVie, Chicago, IL, USA., Waterworth D; Janssen Research & Development, Spring House, PA, USA., Yang R; Janssen Biotech, Beerse, Belgium., Nelis M; Genomics Core Facility, Institute of Genomics, University of Tartu, Tartu, Estonia., Reigo A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Fox C; Merck & Co, Kenilworth, NJ, USA., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Perola M; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Ripatti S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Jalanko A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Laitinen T; Finnish Clinical Biobank Tampere, Tampere University and Tampere University Hospital, Tampere, Finland., Mäkelä TP; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Plenge R; Bristol Myers Squibb, New York, NY, USA., McCarthy M; Genentech, San Francisco, CA, USA., Runz H; Biogen, Cambridge, MA, USA., Daly MJ; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland. aarno.palotie@helsinki.fi.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. aarno.palotie@helsinki.fi.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA. aarno.palotie@helsinki.fi.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. aarno.palotie@helsinki.fi.

Publikováno v: Nature [Nature] 2023 Mar; Vol. 615 (7952), pp. E19.

Texas Department of Human Resources.

Autor: Pendergrass RK

Publikováno v: Texas hospitals [Tex Hosp] 1982 Dec; Vol. 38 (7), pp. 15-6.