The 2-5A system in viral infection and apoptosis

Autor: J Castelli, RJ Youle, KA Wood

Publikováno v: Biomedicine & Pharmacotherapy. 52:386-390

The 2-5A system is an established endogenous antiviral pathway. Interferon treatment of cells leads to an increase in basal, but latent, levels of 2-5A-dependent RNase (RNase L) and the family of 2'-5' oligoadenylate synthetases (OAS). Double-strande

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b92da8b5802dfcd271beb88cec9681
https://doi.org/10.1016/s0753-3322(99)80006-7

Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow

Autor: Rr, Quinones, Rj, Youle, Jh, Kersey, Ed, Zanjani, Sm, Azemove, Cc, Soderling, Tw, Lebien, Peter Beverley, Dm, Neville, Da, Vallera

Publikováno v: Europe PubMed Central

Three murine anti-human monoclonal antibodies broadly reactive with human T cells were conjugated to intact ricin toxin. The purgative effects of these immunotoxins (IT) on alloreactive T cells after in vitro pretreatment was tested in an in vitro as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b09a3dee120cd4ac90e96ecb903d8b6
https://pubmed.ncbi.nlm.nih.gov/6606676

Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation

Autor: Rc, Stong, Fatih M. Uckun, Rj, Youle, Jh, Kersey, Da, Vallera

Publikováno v: Europe PubMed Central

The monoclonal antibodies (MoAb) T101, G3.7, 35.1, and TA-1 were conjugated to intact ricin using a thioether linkage. These MoAb detect, respectively, the CD5[gp67], CD7[p41], CD2[p50], and [gp95, 170] determinants that are found in the vast majorit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d95a03cba14d5c0d8735db27abe65e
https://pubmed.ncbi.nlm.nih.gov/3896347

Acute effects of the skeletal muscle-specific immunotoxin ricin-mAb 35 on extraocular muscles of rabbits

Autor: Sp, Christiansen, Sandnas A, Prill R, Rj, Youle, LInda McLoon

Publikováno v: Experts@Minnesota
Scopus-Elsevier
Europe PubMed Central

To determine the acute histologic and ultrastructural effects of a recently developed muscle-specific immunotoxin, ricin-mAb 35.Graduated doses of ricin-mAb 35, composed of ricin conjugated to a monoclonal antibody against the nicotinic acetylcholine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::56d19e9c403c58bbda5611a833e33ae9
https://experts.umn.edu/en/publications/691b06a8-3cbc-4c92-b7fe-cba488ff8753

STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFκB signaling.

Autor: Fischer TD; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA., Bunker EN; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA., Zhu PP; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA., Guerroué FL; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA., Hadjian M; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA., Dominguez-Martin E; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA., Scavone F; Department of Biochemistry and Molecular Biology, Colorado State University; Fort Collins, CO, USA., Cohen R; Department of Biochemistry and Molecular Biology, Colorado State University; Fort Collins, CO, USA., Yao T; Department of Biochemistry and Molecular Biology, Colorado State University; Fort Collins, CO, USA., Wang Y; Mass Spectrometry, National Institute of Dental and Craniofacial Research, National Institutes of Health; Bethesda, MD, USA., Werner A; Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health; Bethesda, MD, USA., Youle RJ; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.