Expression of the lung resistance protein predicts poor outcome in de novo acute myeloid leukemia

Autor: Filipits M, Pohl G, Stranzl T, Rw, Suchomel, Rj, Scheper, Jäger U, klaus geissler, Lechner K, Pirker R

Publikováno v: Europe PubMed Central

The 110-kD lung resistance protein (LRP) is overexpressed in P-glycoprotein–negative multidrug-resistant cell lines and most likely involved in the multidrug resistance (MDR) of these cell lines. To determine the clinical significance of LRP, we ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce5c27d3993a1faa301d1b4831376bd
https://pubmed.ncbi.nlm.nih.gov/9473213

A MONOCLONAL-ANTIBODY AGAINST HUMAN BETA-GLUCURONIDASE FOR APPLICATION IN ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY

Autor: Hidde Haisma, Vanmuijen, M., Scheffer, G., RJ SCHEPER, HM PINEDO, Boven, E.

Publikováno v: Hybridoma, 14(4), 377-382
University of Groningen

The selectivity of anticancer agents may be improved by antibody-directed enzyme prodrug therapy (ADEPT), The immunogenicity of antibody-enzyme conjugates and the low tumor to normal tissue ratio calls for the use of a human enzyme and the developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::04c073eaca97bc82d6b684a3980b2d9d
https://research.rug.nl/en/publications/dba2a68b-aa4f-4a87-a583-5bf10ddc8484

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein

Autor: GJ Schuurhuis, HJ Broxterman, JHM de Lange, HM Pinedo, THM van Heijningen, CM Kuiper, GL Scheffer, RJ Scheper, CK van Kalken, JPA Baak, J Lankelma

Publikováno v: Schuurhuis, G J, Broxterman, H J, de Lange, J H M, Pinedo, H M, van Heijningen, H M, Kuiper, C M, Scheffer, G L, Scheper, R J, van Kalken, C K & Lankelma, J 1991, ' Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein ', British Journal of Cancer, vol. 64, pp. 857-861 .
British Journal of Cancer, 64, 857-861. Nature Publishing Group
British Journal of Cancer

Resistance to multiple antitumour drugs, mostly antibiotics or alkaloids, has been associated with a cellular plasma membrane P-glycoprotein (Pgp), causing energy-dependent transport of drugs out of cells. However, in many common chemotherapy resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca35b93f3edcbca9a833ce13c219105
https://research.vumc.nl/en/publications/a2056937-1948-4bf7-9737-499de58e8baa

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

Autor: WS Dalton, TM Grogan, JA Rybski, RJ Scheper, L Richter, J Kailey, HJ Broxterman, HM Pinedo, SE Salmon

Publikováno v: Blood. 73(3)

Using several multiple drug-resistant human myeloma cell lines as standards, we developed an immunohistochemical staining technique and means of quantitating P-glycoprotein in individual myeloma cells. The level of staining intensity for P-glycoprote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154d4c70e20790d454ca429f61819857
https://pubmed.ncbi.nlm.nih.gov/2563664

Low intercellular adhesion molecule 1 and high 5T4 expression on tumor cells correlate with reduced disease-free survival in colorectal carcinoma patients

Autor: Wm, Mulder, Pl, Stern, Mj, Stukart, de Windt E, Rm, Butzelaar, Meijer S, Hj, Adér, Am, Claessen, Jb, Vermorken, Cj, Meijer, Wagstaff J, Rj, Scheper, Elisabeth Bloemena

Publikováno v: Europe PubMed Central

The purpose of this study was to investigate the prognostic value of the expression of intercellular adhesion molecule 1 (ICAM-1), leukocyte function antigen 3 (LFA-3), human leukocyte differentiation antigen (HLA)-ABC, HLA-DR, and 5T4 with regard to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::def1b7bb3898e3aebf9e52b16b12525a
http://europepmc.org/abstract/med/9815581