Zobrazeno 1 - 10
of 198
pro vyhledávání: '"RJ Owens"'
Publikováno v:
Europe PubMed Central
The structural features of the human IgA1 tailpiece required for interaction with J chain in IgA dimer assembly were investigated using a protein engineering approach. Wild-type and mutant forms of IgA1 were expressed in the mouse myeloma cell line,
Autor:
DJ King, P Antoniw, RJ Owens, JR Adair, AMR Haines, APH Farnsworth, H Finney, ADG Lawson, A Lyons, TS Baker, D Baldock, J Mackintosh, C Gofton, GT Yarranton, W McWilliams, D Shochat, PK Leichner, S Welt, LJ Old, A Mountain
Publikováno v:
British Journal of Cancer
A humanised IgG1/k version of A33 (hA33) has been constructed and expressed with yields up to 700 mg l-1 in mouse myeloma NS0 cells in suspension culture. The equilibrium dissociation constant of hA33 (KD = 1.3 nM) was shown to be equivalent to that
Publikováno v:
Europe PubMed Central
Publikováno v:
Europe PubMed Central
Ag-specific chimeric human IgA molecules, of the two human subclasses, IgA1 and IgA2, have been expressed in two mammalian cell systems. Analysis of the secreted IgA molecules, purified in milligram quantities from stable Chinese hamster ovary transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02202f970e7c7d0b7c5e51ce1e5106ed
http://europepmc.org/abstract/med/8409433
http://europepmc.org/abstract/med/8409433
Autor:
Aj, Beavil, Rl, Beavil, Cm, Chan, Jp, Cook, Hannah Gould, Aj, Henry, Rj, Owens, Shi J, Bj, Sutton, Rj, Young
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::989828e6c91267152d567865c178983c
http://europepmc.org/abstract/med/8132102
http://europepmc.org/abstract/med/8132102
Autor:
Clarke JD; The Division of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom., Douangamath A; Macromolecular Crystallography, Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom., Mikolajek H; Macromolecular Crystallography, Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom., Bonnet-Di Placido M; Immunogenetics, The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, United Kingdom., Ren J; The Division of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom., Fry EE; The Division of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom., Stuart DI; The Division of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom., Hammond JA; Immunogenetics, The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, United Kingdom., Owens RJ; The Division of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
Publikováno v:
Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Jul 01; Vol. 80 (Pt 7), pp. 154-163. Date of Electronic Publication: 2024 Jul 01.
Autor:
Cornish K; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Huo J; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford , Oxford, UK., Jones L; Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford , Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford , Oxford, UK., Sharma P; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, UK., Thrush JW; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Abdelkarim S; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Kipar A; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, UK.; Vetsuisse Faculty, Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, University of Zurich , Zurich, Switzerland., Ramadurai S; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Weckener M; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Mikolajek H; Diamond Light Source Ltd, Harwell Science Campus , Didcot, UK., Liu S; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford , Oxford, UK., Buckle I; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Bentley E; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, UK., Kirby A; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, UK., Han X; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, UK., Laidlaw SM; Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford , Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford , Oxford, UK., Hill M; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford , Oxford, UK., Eyssen L; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Norman C; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Le Bas A; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., Clarke J; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK., James W; James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford , Oxford, UK., Stewart JP; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, UK., Carroll M; Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford , Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford , Oxford, UK., Naismith JH; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford , Oxford, UK., Owens RJ; Structural Biology, The Rosalind Franklin Institute, Harwell Science Campus , Didcot, UK.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford , Oxford, UK.
Publikováno v:
Open biology [Open Biol] 2024 Jun; Vol. 14 (6), pp. 230252. Date of Electronic Publication: 2024 Jun 04.
Autor:
Rödström KEJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Cloake A; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Sörmann J; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Baronina A; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Smith KHM; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Pike ACW; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Ang J; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Proks P; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Schewe M; Institute of Physiology, Medical Faculty, Kiel University, Kiel, Germany., Holland-Kaye I; Department of Biochemistry, University of Oxford, Oxford, UK., Bushell SR; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Elliott J; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Baukrowitz T; Institute of Physiology, Medical Faculty, Kiel University, Kiel, Germany., Owens RJ; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK.; Division of Structural Biology, University of Oxford, Oxford, UK., Newstead S; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK., Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Carpenter EP; Centre for Medicines Discovery, University of Oxford, Oxford, UK. lizcarpen1@gmail.com.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. lizcarpen1@gmail.com., Tucker SJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2024 May 16; Vol. 15 (1), pp. 4173. Date of Electronic Publication: 2024 May 16.
Autor:
Eyssen LE; Structural Biology, Rosalind Franklin Institute, Didcot, OX11 0QX, UK., Ramadurai S; Structural Biology, Rosalind Franklin Institute, Didcot, OX11 0QX, UK., Abdelkarim S; Structural Biology, Rosalind Franklin Institute, Didcot, OX11 0QX, UK., Buckle I; Structural Biology, Rosalind Franklin Institute, Didcot, OX11 0QX, UK., Cornish K; Structural Biology, Rosalind Franklin Institute, Didcot, OX11 0QX, UK., Lin H; School of Pharmacy, University of Reading, Reading, RG6 6UB, UK., Jones AK; Centre for Dairy Research, University of Reading, Reading, RG2 9HY, UK., Stephens GJ; School of Pharmacy, University of Reading, Reading, RG6 6UB, UK., Owens RJ; Structural Biology, Rosalind Franklin Institute, Didcot, OX11 0QX, UK.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
Publikováno v:
Bio-protocol [Bio Protoc] 2024 Mar 20; Vol. 14 (6), pp. e4962. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).
Autor:
Mycroft-West CJ; The Rosalind Franklin Institute, Harwell Science & Innovation Campus, OX11 0QX, Didcot, UK., Abdelkarim S; The Rosalind Franklin Institute, Harwell Science & Innovation Campus, OX11 0QX, Didcot, UK., Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, OX3 7BN, Oxford, UK., Gandhi NS; Department of Computer Science and Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.; School of Chemistry and Physics, Queensland University of Technology, QLD 4000, Brisbane, Australia.; Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, QLD 4059, Australia., Skidmore MA; Centre for Glycoscience Research and Training, Keele University, ST5 5BG, Newcastle-Under-Lyme, UK., Owens RJ; The Rosalind Franklin Institute, Harwell Science & Innovation Campus, OX11 0QX, Didcot, UK.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, OX3 7BN, Oxford, UK., Wu L; The Rosalind Franklin Institute, Harwell Science & Innovation Campus, OX11 0QX, Didcot, UK. liang.wu@rfi.ac.uk.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, OX3 7BN, Oxford, UK. liang.wu@rfi.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2024 Feb 13; Vol. 15 (1), pp. 1326. Date of Electronic Publication: 2024 Feb 13.