MicroRNA biogenesis. Part 2. Formation of mature miRNAs. Maturation of non-canonical miRNAs

Autor: A.E. Abaturov, V.L. Babуch

Publikováno v: Zdorovʹe Rebenka, Vol 16, Iss 3, Pp 257-263 (2021)
CHILD`S HEALTH; Vol. 16 No. 3 (2021); 257-263
Здоровье ребенка-Zdorovʹe rebenka; Том 16 № 3 (2021); 257-263
Здоров'я дитини-Zdorovʹe rebenka; Том 16 № 3 (2021); 257-263

The scientific review presents the biogenesis of miRNAs. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka. The article sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fe7aa7deb5801e0cec7d6de5e73119
https://doi.org/10.22141/2224-0551.16.3.2021.233912

AGO2 phosphorylation by c-Src kinase promotes tumorigenesis

Autor: Ran Chen, Zhi Yang, Hailong Zhang, Yanli Wang, Shengfang Ge, Jianxiu Yu, Tianqi Liu, Jiayu Fang, Jian Huang, Xian Zhao

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 3, Pp 129-141 (2020)
Neoplasia (New York, N.Y.)

Numerous studies have reported that c-Src is highly expressed with high tyrosine kinase activity in a variety of tumors. However, it remains unclear whether c-Src contributes to the miRNA pathway. Here, we report that c-Src can interact with and phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c464bc31bf758ee159108f52b67cb982
http://www.sciencedirect.com/science/article/pii/S1476558619303914

Computational Detection of MicroRNA Targets

Autor: Pedro G. Nachtigall, Luiz A. Bovolenta

Publikováno v: Methods in Molecular Biology ISBN: 9781071611692

MicroRNAs (miRNAs) are small noncoding RNAs that are recognized as posttranscriptional regulators of gene expression. These molecules have been shown to play important roles in several cellular processes. MiRNAs act on their target by guiding the RIS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ba1d632ea2a72cf478c6c87808ccc01
https://doi.org/10.1007/978-1-0716-1170-8_10

Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells

Autor: Giovanni Blandino, Andrea Sacconi, Silvia Masciarelli, Giulia Fontemaggi, Luciana De Angelis, Paolo Rosa, Francesco Fazi, Natale Porta, Mirko Cirenza, Claudia Tito, Giuseppe Di Martino, Teresa Bellissimo, Antonella Calogero, Vincenzo Petrozza, Federica Ganci, Melissa Sorci, Alessandro Fatica

Publikováno v: Cell Death and Disease, Vol 10, Iss 1, Pp 1-12 (2019)
Cell Death & Disease

To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammalian Argonaute (Ago) family of proteins, Ago1–4, into an effector complex known as the RNA-induced silencing complex (RISC). While the mature miRNA gu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad0504665e8452f2de7e8d5f072510d
http://link.springer.com/article/10.1038/s41419-018-1267-5

The 2'-caged-tethered-siRNA shows light-dependent temporal controlled RNAi activity for GFP gene into HEK293T cells

Autor: Manjusha Dixit, Amarnath Bollu, Nagendra K. Sharma, Md. Khurshidul Hassan

Publikováno v: Bioorganicmedicinal chemistry. 30

Small interfering RNA (siRNA) exhibits gene-specific RNAi activity by the formation of RISC complex with mRNA of gene. The structural modification of siRNA at appropriate positions affects the structure of RISC complex and then RNAi activity. The mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e9586b595f3c6074d65a249d3d0936
https://pubmed.ncbi.nlm.nih.gov/33316720