Výsledky vyhledávání - "RIPK, Receptor interacting protein kinase"

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

Autor: Sjoerd J L van Wijk, Anne-Kathrin Knuth, Stefanie Rösler, Barbara Schenk, Lisa Kowald, Simone Fulda

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 74-81 (2019)
Neoplasia (New York, N.Y.)

Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). Here, we identify the mixed-lineage kinase domain-like pseudokinase (MLKL) as an ISG in various cancer cell lines. Both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5938629e1af1e96d676b42488b98ebbd
http://www.sciencedirect.com/science/article/pii/S1476558618304366

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Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice

Autor: Hideto Kameda, Naomi Nakagata, Takashi Nishina, Takashi Yamamoto, Wakami Takeda, Hiroyasu Nakano, Chiharu Nishiyama, Ryodai Shindo, Masaki Ohmuraya, Tetsushi Sakuma, Soh Yamazaki, Yoshiko Nakagawa, Sachiko Komazawa-Sakon, Takaharu Katagiri

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 21, Iss, Pp-(2020)

Regenerating islet-derived protein (Reg)3β belongs to a member of the Reg family of proteins and has pleiotropic functions, including antimicrobial activity and tissue repair. However, whether Reg3β plays a protective role in the development of col

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3d9864e801ba7e4d58e1a9b7a7475c
https://pubmed.ncbi.nlm.nih.gov/32072024

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gRASping the redox lever to modulate cancer cell fate signaling

Autor: Chuan Han Jonathan Foo, Shazib Pervaiz

Publikováno v: Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology

RAS proteins are critical regulators of signaling networks controlling diverse cellular functions such as cell proliferation and survival and its mutation are among the most powerful oncogenic drivers in human cancers. Despite intense efforts, direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11cd3c78529b5f4eae7369f41a3e411
http://www.sciencedirect.com/science/article/pii/S2213231718311558

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Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

Autor: Norihiko Takeda, Kenji Takemoto, Saori Ohmae, Satoru Seo, Shinji Uemoto, Masataka Asagiri, Hirokazu Tanaka, Naruto Noma, Shigehira Saji, Keigo Machida, Kazutaka Tanabe, Masatoshi Takeiri, Kojiro Taura, Etsuro Hatano, Keiko Iwaisako, Kan Toriguchi

Publikováno v: FEBS Open Bio
FEBS Open Bio, Vol 4, Iss C, Pp 777-787 (2014)

Graphical abstract
Highlights • RIPK-dependent necrosis is involved in acetaminophen (APAP)-induced hepatotoxicity. • Necrostatin-1 (Nec-1) protects mice against APAP-induced acute liver damage. • Nec-1 suppresses APAP-induced ROS generati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6824035213e5d61dffb40cdc54c001d9
http://hdl.handle.net/2433/191145

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Akademický článek

Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice.

Autor: Shindo R; Department of Biochemistry, Toho University Graduate School Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan., Katagiri T; Department of Biochemistry, Toho University Graduate School Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan.; Division of Rheumatology, Department of Internal Medicine, Ohashi Medical Center, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan., Komazawa-Sakon S; Department of Biochemistry, Toho University Graduate School Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan., Ohmuraya M; Department of Genetics, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan., Takeda W; Laboratory of Molecular Biology and Immunology, Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan., Nakagawa Y; Center for Animal Resources and Development, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan., Nakagata N; Center for Animal Resources and Development, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan., Sakuma T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan., Yamamoto T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan., Nishiyama C; Laboratory of Molecular Biology and Immunology, Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan., Nishina T; Department of Biochemistry, Toho University Graduate School Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan., Yamazaki S; Department of Biochemistry, Toho University Graduate School Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan., Kameda H; Division of Rheumatology, Department of Internal Medicine, Ohashi Medical Center, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan., Nakano H; Department of Biochemistry, Toho University Graduate School Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan.; Host Defense Research Center, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo, 143-8540, Japan.

Publikováno v: Biochemistry and biophysics reports [Biochem Biophys Rep] 2020 Feb 07; Vol. 21, pp. 100738. Date of Electronic Publication: 2020 Feb 07 (Print Publication: 2020).

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Akademický článek

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.

Autor: Takemoto K; Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan ; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Hatano E; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Iwaisako K; Department of Target Therapy Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Takeiri M; Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan., Noma N; Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan., Ohmae S; Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan., Toriguchi K; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Tanabe K; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Tanaka H; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Seo S; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Taura K; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Machida K; Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA., Takeda N; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan., Saji S; Department of Target Therapy Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Uemoto S; Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto 606-8507, Japan., Asagiri M; Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.

Publikováno v: FEBS open bio [FEBS Open Bio] 2014 Sep 06; Vol. 4, pp. 777-87. Date of Electronic Publication: 2014 Sep 06 (Print Publication: 2014).

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