Zobrazeno 1 - 10 of 46 pro vyhledávání: '"RIPA, radioimmunoprecipitation"'
1
Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats
Autor: Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)
Background & Aims: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2-/- mice replicate the human phenotype but were n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501eab0983bab28ced1482110d3291c
http://europepmc.org/articles/PMC8804273
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2
Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage
Autor: Chuyao Liao, Di Wang, Ying Zhang, Zunjian Zhang, Fengguo Xu, Siyuan Qin, Yuxin Zhang, Danting Li, Yuan Tian, Jie Chen
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 763-780 (2021)
Acta Pharmaceutica Sinica. B
Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal of approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly character
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af930bc5ea3c9fbae9d582539b35a5f
https://doi.org/10.1016/j.apsb.2020.07.017
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3
ANKRD22 Drives Rapid Proliferation of Lgr5+ Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury
Autor: Rui Wang, Dandan Zhong, Yiqing Qiu, Jingni Wu, Yongliang Zhu, Zhenya Song, Jingwen Liu, Hongping Wang
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1433-1455 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Rapid gastric epithelial progenitor cell (EPC) proliferation and inflammatory response inhibition play key roles in promoting the repair of gastric mucosal damage. However, specific targets inducing these effects are unknown. In thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f416abd6bb2732c90ffabe02f872fe52
https://doi.org/10.1016/j.jcmgh.2021.06.020
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4
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing
Autor: Yi-Chao Zheng, Hong-Min Liu, Ouwen Li, Jun-Wei Wang, Zhenhe Suo, Fengyu Qi, Wen-Ting Kang, Pengxing He, Zhi-Ru Wang, Yinghua You
Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 694-707 (2021)
Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for treating melanoma, gastric cancer (GC) and bladder cancer with clinical benefit. Nevertheless, many patients fail
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3f6e9de03bb3ad460a61d5471e4bca
http://europepmc.org/articles/PMC7982505
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5
Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury
Autor: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel
Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciences
Testicular torsion and detorsion (TTD) is a serious urological condition affecting young males that is underlined by an ischemia reperfusion injury (tIRI) to the testis as the pathophysiological mechanism. During tIRI, uncontrolled production of oxyg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69
http://www.sciencedirect.com/science/article/pii/S1319562X20301364
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6
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis
Autor: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An
Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)
Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fb5bad337ad6389f2c3000e4927a2
http://europepmc.org/articles/PMC7488361
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7
Reduced expression of carbonic anhydrase III in skeletal muscles could be linked to muscle fatigue: A rat muscle fatigue model
Autor: Hongwei Fang, Peng Shang, Min Li, Atik Badshah Shaikh, Shiyi Chen, Xiliang Shang
Publikováno v: Journal of Orthopaedic Translation, Vol 22, Iss, Pp 116-123 (2020)
Journal of Orthopaedic Translation
Background: Carbonic anhydrase III (CAIII) is expressed abundantly in slow skeletal muscles, adipocytes, and the liver. It plays a critical role in maintaining intracellular pH, antioxidation, and energy metabolism, which are further involved in fati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c600ccef46d6cbd3d31f526038b73
http://www.sciencedirect.com/science/article/pii/S2214031X19302049
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8
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins
Autor: Yong Xiong, Fidel Arizaga, Adrian Oo, Nicole E. Bowen, Caitlin Shepard, Baek Kim, David S. Yu, Joshua Temple, Corey H. Yu, Dmitri N. Ivanov, Felipe Diaz-Griffero, Dong-Hyun Kim, Mirjana Persaud, Priya Kapoor-Vazirani, Raymond F. Schinazi
Publikováno v: The Journal of Biological Chemistry
Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of cancer cells. Recently, a series of mutations in the multifunctional dNTP triphosphohydrolase (dNTPase), sterile alpha motif and histidine–aspartate domain–conta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3d00b0911c2e38bfb2f2ebb6ba3fbe
https://pubmed.ncbi.nlm.nih.gov/34492268
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9
FOXO3a inhibits the EMT and metastasis of breast cancer by regulating TWIST-1 mediated miR-10b/CADM2 axis
Autor: Xi Zhang, Long Jin, Hui-Qun Fu, Yuliang Pan, Jun Zhang
Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 7, Pp 101096-(2021)
Highlights • FOXO3a was down-regulated and TWIST-1 was up-regulated in breast cancer tissues. • Overexpression of FOXO3a suppressed the EMT and metastasis of breast cancer. • Knockdown of TWIST-1 inhibited the EMT and metastasis of breast cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70df0f04d470a09d0748c1247de8c9bc
http://europepmc.org/articles/PMC8081990
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10
Long non-coding RNA BLACAT1 expedites osteosarcoma cell proliferation, migration and invasion via up-regulating SOX12 through miR-608
Autor: Yubao Cui, Xiaotao Chen, Yanming Ma
Publikováno v: Journal of Bone Oncology, Vol 25, Iss, Pp 100314-(2020)
Journal of Bone Oncology
Highlights • BLACAT1 promotes cell proliferation, migration and invasion, and dampens cell apoptosis in OS. • BLACAT1 sponges miR-608 in OS. • SOX12 is the target of miR-608. • BLACA1 promotes OS cell growth and migration via targeting miR-60
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e419725433635817b7c2d2f13415912
http://www.sciencedirect.com/science/article/pii/S2212137420300695
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