Zobrazeno 1 - 10
of 607
pro vyhledávání: '"RICHARD L. SIMMONS"'
Autor:
Celine Tohme, Tony Haykal, Ruiqi Yang, Taylor J. Austin, Patricia Loughran, David A. Geller, Richard L. Simmons, Samer Tohme, Hamza O. Yazdani
Publikováno v:
Cells, Vol 13, Iss 17, p 1448 (2024)
Background: Exercise can promote sustainable protection against cold and warm liver ischemia–reperfusion injury (IRI) and tumor metastases. We have shown that this protection is by the induction of hepatic mitochondrial biogenesis pathway. In this
Externí odkaz:
https://doaj.org/article/fb2e62d8e57f457099f6cc270bf554e4
Autor:
Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-11 (2021)
Abstract Background Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response. Methods Using network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level
Externí odkaz:
https://doaj.org/article/661d12bce8a244c99e15f56f6542a73d
Autor:
Nabil Azhar, Rami A. Namas, Khalid Almahmoud, Akram Zaaqoq, Othman A. Malak, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Andrew Abboud, Richard L. Simmons, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients
Externí odkaz:
https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc50
Autor:
Christof Kaltenmeier, Hamza O. Yazdani, Kristin Morder, David A. Geller, Richard L. Simmons, Samer Tohme
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
While neutrophil extracellular traps (NETs) are important for directly promoting cancer growth, little is known about their impact on immune cells within the tumor microenvironment (TME). We hypothesize that NETs can directly interact with infiltrati
Externí odkaz:
https://doaj.org/article/5348aaf05b064dc9b2d68480273e0038
Autor:
Hongji Zhang, Julie Goswami, Patrick Varley, Dirk J. van der Windt, Jinghua Ren, Patricia Loughran, Hamza Yazdani, Matthew D. Neal, Richard L. Simmons, Jinxiang Zhang, Allan Tsung, Hai Huang
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Innate immunity can initiate platelet activation during the development of thrombosis through a process, termed immunothrombosis. Neutrophils form neutrophil extracellular traps (NETs) that have been shown to interact directly with platelets and play
Externí odkaz:
https://doaj.org/article/9314d5508361467d826997a44ad59949
Autor:
Dongmei Liu, Rami A. Namas, Yoram Vodovotz, Andrew B. Peitzman, Richard L. Simmons, Hong Yuan, Qi Mi, Timothy R. Billiar
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Purpose: We sought to identify a MODS score parameter that highly correlates with adverse outcomes and then use this parameter to test the hypothesis that multiple severity-based MODS clusters could be identified after blunt trauma.Methods: MOD score
Externí odkaz:
https://doaj.org/article/9facb1ed0dd9402fa354ee00b837fab1
Autor:
Yoram Vodovotz, Richard L. Simmons, Chandrashekhar R. Gandhi, Derek Barclay, Bahiyyah S. Jefferson, Chao Huang, Rami Namas, Fayten el-Dehaibi, Qi Mi, Timothy R. Billiar, Ruben Zamora
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
We hypothesized that isolated primary mouse hepatic stellate cells (HSC) and hepatocytes (HC) would elaborate different inflammatory responses to hypoxia with or without reoxygenation. We further hypothesized that intracellular information processing
Externí odkaz:
https://doaj.org/article/b95f5dfa3217401d8be4c22adaa36c19
Autor:
Allan Tsung, Hai Huang, Richard L. Simmons, Yanming Wang, Kerri Mowen, Patricia Loughran, Alexis P. Chidi, Ahmed B. Al-Khafaji, Hamza O. Yazdani, Samer Tohme
Supplementary Figure 2 contains results showing 1) increased hypoxia and NET formation in human resected metastatic colorectal cancer tumors. 2) Protumorigenic effects of NETs in Hep1-6 cancer cell lines. 3)Increased HMGB1 levels in patients after ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5532a38aabbeb37a146224dc7aa41b11
https://doi.org/10.1158/0008-5472.22410330.v1
https://doi.org/10.1158/0008-5472.22410330.v1
Autor:
Allan Tsung, Hai Huang, Richard L. Simmons, Yanming Wang, Kerri Mowen, Patricia Loughran, Alexis P. Chidi, Ahmed B. Al-Khafaji, Hamza O. Yazdani, Samer Tohme
Risks of tumor recurrence after surgical resection have been known for decades, but the mechanisms underlying treatment failures remain poorly understood. Neutrophils, first-line responders after surgical stress, may play an important role in linking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d74857a78a87d8387980608c0dd5c91
https://doi.org/10.1158/0008-5472.c.6507969
https://doi.org/10.1158/0008-5472.c.6507969
Autor:
Allan Tsung, Hai Huang, Richard L. Simmons, Yanming Wang, Kerri Mowen, Patricia Loughran, Alexis P. Chidi, Ahmed B. Al-Khafaji, Hamza O. Yazdani, Samer Tohme
Legends for Supplementary Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059408736560f3fcfdc981aebcb3d408
https://doi.org/10.1158/0008-5472.22410336
https://doi.org/10.1158/0008-5472.22410336