Zobrazeno 1 - 10
of 489
pro vyhledávání: '"RICHARD J. ROMAN"'
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Although the causes of cognitive impairment are multifactorial, emerging evidence indicates that cerebrovascular dysfunction plays an essential role in dementia. One of the most critical aspects of cerebrovascular dysfunction is autoregulation of cer
Externí odkaz:
https://doaj.org/article/bef8919a9b214ddbbdc65b9a4ecda7a2
Autor:
Junie P. Warrington, Fan Fan, Jeremy Duncan, Mark W. Cunningham, Babette B. LaMarca, Ralf Dechend, Gerd Wallukat, Richard J. Roman, Heather A. Drummond, Joey P. Granger, Michael J. Ryan
Publikováno v:
Biology of Sex Differences, Vol 10, Iss 1, Pp 1-8 (2019)
Abstract Background Placental ischemia and hypertension, characteristic features of preeclampsia, are associated with impaired cerebral blood flow (CBF) autoregulation and cerebral edema. However, the factors that contribute to these cerebral abnorma
Externí odkaz:
https://doaj.org/article/3faa9b7e7c044e9e8fbb15617256efe5
Autor:
Ezekiel Gonzalez-Fernandez, Daniel Staursky, Kathryn Lucas, Bond V. Nguyen, Man Li, Yedan Liu, Chad Washington, Lique M. Coolen, Fan Fan, Richard J. Roman
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
20-HETE is a potent vasoconstrictor that is implicated in the regulation of blood pressure, cerebral blood flow and neuronal death following ischemia. Numerous human genetic studies have shown that inactivating variants in the cytochrome P450 enzymes
Externí odkaz:
https://doaj.org/article/1ef8b5704a394a9c9240143c37a0137d
Autor:
Huawei Zhang, Chao Zhang, Yedan Liu, Wenjun Gao, Shaoxun Wang, Xing Fang, Ya Guo, Man Li, Ruen Liu, Richard J. Roman, Peng Sun, Fan Fan
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract We recently reported that KO of Dual‐specificity protein phosphatase 5 (Dusp5) enhances myogenic reactivity and blood flow autoregulation in the cerebral and renal circulations in association with increased levels of pPKC and pERK1/2 in th
Externí odkaz:
https://doaj.org/article/9f34c41df2414f319e7936b45ad178f9
Autor:
Letao Fan, Shaoxun Wang, Xiaochen He, Ezekiel Gonzalez‐Fernandez, Claude Lechene, Fan Fan, Richard J. Roman
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Abstract This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions. Kid
Externí odkaz:
https://doaj.org/article/2f21f99aa78246ff8039ae69afcdac78
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of the initial injury, renal fibrosis is the common final pathway leading to end stage renal disease. Although the underlying mechanisms are not fully defined, evi
Externí odkaz:
https://doaj.org/article/fa7de52cc3ac421690f44c3bbe1896ed
Autor:
Takayuki Seki, Tsuyoshi Ishimoto, Takanobu Sakurai, Yoshiko Yasuda, Kazuo Taniguchi, Mariko Doi, Mariko Sato, Richard J. Roman, Noriyuki Miyata
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 1, Pp 132-137 (2005)
The present study examined the contribution of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) in cyclosporine A (CsA)-induced renal nephrotoxicity. Treatment of rats with CsA (50 mg/kg) for 9 days induced renal damage as indicated by marked inc
Externí odkaz:
https://doaj.org/article/29be99a05d2645118f80e1033015b67e
Publikováno v:
Journal of Cardiovascular Pharmacology. 80:206-209
Septic shock is life-threatening organ dysfunction due to a dysregulated response to infection. It is a leading cause of death caused by the excessive release of cytokines and inflammatory mediators in response to bacterial endotoxins. It produces hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fbdb764e10cd898af06259f592372c
https://doi.org/10.1097/fjc.0000000000001300
https://doi.org/10.1097/fjc.0000000000001300
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e8a6e78c2d7c34bf8de58ea5b26700
https://doi.org/10.1124/jpet.122.202220
https://doi.org/10.1124/jpet.122.202220
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?
Publikováno v:
GeroScience
From the first described AD case in 1901 to the current year 2022, understanding the pathogenesis of Alzheimer’s disease (AD) and dementia has undergone a long and tortuous journey. Many mechanisms of AD etiology have been proposed and studied. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9466a16c884ac7c317ed9934aa104ab3
https://doi.org/10.1007/s11357-022-00591-7
https://doi.org/10.1007/s11357-022-00591-7